TMEM163 (transmembrane protein 163)

Gene

• Entrez ID: 81615
• Gene name: Transmembrane protein 163
• Gene symbol: TMEM163
• Synonyms (NCBI Gene): DC29, HLD25, SLC30A11, SV31
• Disease Acronyms (UniProt): HLD25
• Chromosome: 2
• Chromosome location: 2q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017779	hsa-miR-335-5p	Microarray	18185580
MIRT641381	hsa-miR-1255b-2-3p	HITS-CLIP	23824327
MIRT641381	hsa-miR-1255b-2-3p	HITS-CLIP	23824327
MIRT1431799	hsa-miR-125a-3p	CLIP-seq
MIRT1431800	hsa-miR-1271	CLIP-seq
MIRT1431801	hsa-miR-3156-5p	CLIP-seq
MIRT1431802	hsa-miR-3650	CLIP-seq
MIRT1431803	hsa-miR-3665	CLIP-seq
MIRT1431804	hsa-miR-3927	CLIP-seq
MIRT1431805	hsa-miR-4488	CLIP-seq
MIRT1431806	hsa-miR-4519	CLIP-seq
MIRT1431807	hsa-miR-4695-3p	CLIP-seq
MIRT1431808	hsa-miR-4697-5p	CLIP-seq
MIRT1431809	hsa-miR-4736	CLIP-seq
MIRT1431810	hsa-miR-4793-5p	CLIP-seq
MIRT1431811	hsa-miR-660	CLIP-seq
MIRT1431812	hsa-miR-935	CLIP-seq
MIRT1431813	hsa-miR-96	CLIP-seq
MIRT2129445	hsa-miR-1910	CLIP-seq
MIRT2129446	hsa-miR-193a-5p	CLIP-seq
MIRT2129447	hsa-miR-3689d	CLIP-seq
MIRT2129448	hsa-miR-4264	CLIP-seq
MIRT2129449	hsa-miR-4527	CLIP-seq
MIRT2129450	hsa-miR-455-3p	CLIP-seq
MIRT2129451	hsa-miR-4717-3p	CLIP-seq
MIRT2129452	hsa-miR-4802-3p	CLIP-seq
MIRT2129453	hsa-miR-490-5p	CLIP-seq
MIRT2129454	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0008270	Function	Zinc ion binding	IBA	21873635
GO:0008270	Function	Zinc ion binding	ISS
GO:0016020	Component	Membrane	IBA	21873635
GO:0030285	Component	Integral component of synaptic vesicle membrane	IBA	21873635
GO:0030285	Component	Integral component of synaptic vesicle membrane	ISS
GO:0031901	Component	Early endosome membrane	ISS
GO:0099180	Process	Zinc ion import into synaptic vesicle	IEA

Other IDs

• MIM: 618978
• HGNC: 25380
• e!Ensembl: ENSG00000152128

Protein

• UniProt ID: Q8TC26
• Protein name: Transmembrane protein 163
• Protein function: Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (PubMed:25130899, PubMed:31697912, PubMed:36204728). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity
• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. High expression is detected in brain, lung and testis. {ECO:0000269|PubMed:25130899}.
• Sequence:

  MEPAAGIQRRSSQGPTVPPPPRGHAPPAAAPGPAPLSSPVREPPQLEEERQVRISESGQF
  SDGLEDRGLLESSTRLKPHEAQNYRKKALWVSWFSIIVTLALAVAAFTVSVMRYSASAFG
  FAFDAILDVLSSAIVLWRYSNAAAVHSAHREYIACVILGVIFLLSSICIVVKAIHDLSTR
  LLPEVDDFLFSVSILSGILCSILAVLKFMLGKVLTSRALITDGFNSLVGGVMGFSILLSA
  EVFKHDSAVWYLDGSIGVLIGLTIFAYGVKLLIDMVPRVRQTRHYEMFE

• Sequence length: 289

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537	17634449
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	23209189

Unknown
Disease term	Disease name	Evidence	References	Source
Leukodystrophy	leukodystrophy, hypomyelinating, 25			GenCC
Neuroticism	Neuroticism			GWAS
Diabetes	Diabetes			GWAS
Biliary Cholangitis	Biliary Cholangitis			GWAS
Alzheimer disease	Alzheimer disease			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	35205284
Carcinoma Pancreatic Ductal	Associate	33574088
Diabetes Mellitus Type 2	Associate	26290879
Parkinson Disease	Associate	27393345, 33523105