Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	81610
Gene name Gene Name - the full gene name approved by the HGNC.	Family with sequence similarity 83 member D
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FAM83D
Synonyms (NCBI Gene) Gene synonyms aliases	C20orf129, CHICA, dJ616B8.3
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q11.23

Show/Hide all(114)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022620	hsa-miR-124-3p	Microarray	18668037
MIRT024511	hsa-miR-215-5p	Microarray	19074876
MIRT026481	hsa-miR-192-5p	Microarray	19074876
MIRT658345	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT658344	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT658343	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT658342	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT658341	hsa-miR-635	HITS-CLIP	23824327
MIRT658340	hsa-miR-6774-5p	HITS-CLIP	23824327
MIRT658339	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT658338	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT658336	hsa-miR-4284	HITS-CLIP	23824327
MIRT658337	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT658334	hsa-miR-4507	HITS-CLIP	23824327
MIRT658335	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT523778	hsa-miR-4438	PAR-CLIP	23446348
MIRT523777	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT523776	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT523775	hsa-miR-6741-3p	PAR-CLIP	23446348
MIRT523774	hsa-miR-5095	PAR-CLIP	23446348
MIRT523773	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT523772	hsa-miR-5691	PAR-CLIP	23446348
MIRT523771	hsa-miR-6805-3p	PAR-CLIP	23446348
MIRT440673	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440674	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT440673	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT727695	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT727694	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT727693	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT727692	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT153283	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT153284	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT440674	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT658343	hsa-miR-1304-3p	HITS-CLIP	27418678
MIRT658345	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT658344	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT658343	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT658342	hsa-miR-2276-3p	HITS-CLIP	23824327
MIRT658341	hsa-miR-635	HITS-CLIP	23824327
MIRT658340	hsa-miR-6774-5p	HITS-CLIP	23824327
MIRT658339	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT658338	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT658336	hsa-miR-4284	HITS-CLIP	23824327
MIRT658337	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT658334	hsa-miR-4507	HITS-CLIP	23824327
MIRT658335	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT523778	hsa-miR-4438	PAR-CLIP	23446348
MIRT523777	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT523776	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT523775	hsa-miR-6741-3p	PAR-CLIP	23446348
MIRT523774	hsa-miR-5095	PAR-CLIP	23446348
MIRT523773	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT523772	hsa-miR-5691	PAR-CLIP	23446348
MIRT523771	hsa-miR-6805-3p	PAR-CLIP	23446348
MIRT987660	hsa-miR-1183	CLIP-seq
MIRT987661	hsa-miR-1283	CLIP-seq
MIRT987662	hsa-miR-130a	CLIP-seq
MIRT987663	hsa-miR-130b	CLIP-seq
MIRT987664	hsa-miR-138	CLIP-seq
MIRT987665	hsa-miR-142-3p	CLIP-seq
MIRT987666	hsa-miR-194	CLIP-seq
MIRT987667	hsa-miR-200b	CLIP-seq
MIRT987668	hsa-miR-200c	CLIP-seq
MIRT987669	hsa-miR-217	CLIP-seq
MIRT987670	hsa-miR-301a	CLIP-seq
MIRT987671	hsa-miR-301b	CLIP-seq
MIRT987672	hsa-miR-3149	CLIP-seq
MIRT987673	hsa-miR-3666	CLIP-seq
MIRT987674	hsa-miR-3668	CLIP-seq
MIRT987675	hsa-miR-3713	CLIP-seq
MIRT987676	hsa-miR-3924	CLIP-seq
MIRT987677	hsa-miR-4282	CLIP-seq
MIRT987678	hsa-miR-429	CLIP-seq
MIRT987679	hsa-miR-4295	CLIP-seq
MIRT987680	hsa-miR-4299	CLIP-seq
MIRT987681	hsa-miR-4418	CLIP-seq
MIRT987682	hsa-miR-4427	CLIP-seq
MIRT987683	hsa-miR-4527	CLIP-seq
MIRT987684	hsa-miR-4528	CLIP-seq
MIRT987685	hsa-miR-454	CLIP-seq
MIRT987686	hsa-miR-4671-3p	CLIP-seq
MIRT987687	hsa-miR-4712-3p	CLIP-seq
MIRT987688	hsa-miR-4793-3p	CLIP-seq
MIRT987689	hsa-miR-4803	CLIP-seq
MIRT987690	hsa-miR-486-5p	CLIP-seq
MIRT987691	hsa-miR-495	CLIP-seq
MIRT987692	hsa-miR-499-3p	CLIP-seq
MIRT987693	hsa-miR-499a-3p	CLIP-seq
MIRT987694	hsa-miR-509-3-5p	CLIP-seq
MIRT987695	hsa-miR-509-5p	CLIP-seq
MIRT987696	hsa-miR-616	CLIP-seq
MIRT987697	hsa-miR-649	CLIP-seq
MIRT987660	hsa-miR-1183	CLIP-seq
MIRT987666	hsa-miR-194	CLIP-seq
MIRT987667	hsa-miR-200b	CLIP-seq
MIRT987668	hsa-miR-200c	CLIP-seq
MIRT1992676	hsa-miR-330-3p	CLIP-seq
MIRT987678	hsa-miR-429	CLIP-seq
MIRT1992677	hsa-miR-4422	CLIP-seq
MIRT987687	hsa-miR-4712-3p	CLIP-seq
MIRT987689	hsa-miR-4803	CLIP-seq
MIRT987660	hsa-miR-1183	CLIP-seq
MIRT987666	hsa-miR-194	CLIP-seq
MIRT987667	hsa-miR-200b	CLIP-seq
MIRT987668	hsa-miR-200c	CLIP-seq
MIRT987678	hsa-miR-429	CLIP-seq
MIRT987682	hsa-miR-4427	CLIP-seq
MIRT987688	hsa-miR-4793-3p	CLIP-seq
MIRT987689	hsa-miR-4803	CLIP-seq
MIRT1992676	hsa-miR-330-3p	CLIP-seq
MIRT1992677	hsa-miR-4422	CLIP-seq
MIRT2449431	hsa-miR-3145-3p	CLIP-seq
MIRT1992677	hsa-miR-4422	CLIP-seq
MIRT2449432	hsa-miR-4662a-3p	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001837	Process	Epithelial to mesenchymal transition	IDA	24344117
GO:0005515	Function	Protein binding	IPI	23455922, 24344117, 29789297
GO:0005737	Component	Cytoplasm	IC	24736947, 25646692
GO:0005737	Component	Cytoplasm	IDA	18445686, 18485706
GO:0005819	Component	Spindle	IDA	18445686
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0008017	Function	Microtubule binding	IDA	18485706
GO:0008283	Process	Cell population proliferation	IDA	24344117, 25646692
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016477	Process	Cell migration	IDA	24344117
GO:0019894	Function	Kinesin binding	IPI	18485706
GO:0019901	Function	Protein kinase binding	IBA	21873635
GO:0019901	Function	Protein kinase binding	IPI	24736947
GO:0032006	Process	Regulation of TOR signaling	IBA	21873635
GO:0032006	Process	Regulation of TOR signaling	IDA	24344117
GO:0042176	Process	Regulation of protein catabolic process	IDA	24344117
GO:0045171	Component	Intercellular bridge	IDA
GO:0051301	Process	Cell division	IEA
GO:0051310	Process	Metaphase plate congression	IMP	18485706
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IBA	21873635
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IMP	24736947, 25646692
GO:0072686	Component	Mitotic spindle	IDA
GO:0097431	Component	Mitotic spindle pole	IBA	21873635
GO:0097431	Component	Mitotic spindle pole	IDA	15561729, 18485706
GO:1902480	Process	Protein localization to mitotic spindle	IBA	21873635
GO:1902480	Process	Protein localization to mitotic spindle	IMP	18485706
GO:1902808	Process	Positive regulation of cell cycle G1/S phase transition	IBA	21873635
GO:1902808	Process	Positive regulation of cell cycle G1/S phase transition	IMP	25646692

MIM	HGNC	e!Ensembl
618380	16122	ENSG00000101447

Protein

UniProt ID

Q9H4H8

Protein name

Protein FAM83D (Spindle protein CHICA)

Protein function

Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:2564

PDB

5E0L , 5E0M

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07894	FAM83	17 → 296	FAM83 A-H	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the testis. {ECO:0000269|PubMed:22965910}.

Sequence

MALLSEGLDEVPAACLSPCGPPNPTELFSESRRLALEELVAGGPEAFAAFLRRERLARFL
NPDEVHAILRAAERPGEEGAAAAAAAEDSFGSSHDCSSGTYFPEQSDLEPPLLELGWPAF
YQGAYRGATRVETHFQPRGAGEGGPYGCKDALRQQLRSAREVIAVVMDVFTDIDIFRDLQ
EICRKQGVAVYILLDQALLSQFLDMCMDLKVHPEQEKLMTVRTITGNIYYARSGTKIIGK
VHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILSGQVVEHFDLEFRILYAQSKPISPK
LLSHFQSSNKFDHLTNRKPQSKELTLGNLLRMRLARLSSTPRKADLDPEMPAEGKAERKP
HDCESSTVSEEDYFSSHRDELQSRKAIDAATQTEPGEEMPGLSVSEVGTQTSITTACAGT
QTAVITRIASSQTTIWSRSTTTQTDMDENILFPRGTQSTEGSPVSKMSVSRSSSLKSSSS
VSSQGSVASSTGSPASIRTTDFHNPGYPKYLGTPHLELYLSDSLRNLNKERQFHFAGIRS
RLNHMLAMLSRRTLFTENHLGLHSGNFSRVNLLAVRDVALYPSYQ

Sequence length

585

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Schizophrenia	Schizophrenia			GWAS

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	36710419
Anophthalmia with pulmonary hypoplasia	Stimulate	33747255
Breast Neoplasms	Stimulate	24344117
Breast Neoplasms	Associate	31758680, 35650627, 37958803
Carcinogenesis	Associate	34308751
Carcinoma Hepatocellular	Stimulate	26125229
Carcinoma Hepatocellular	Associate	30910840, 34308751, 36710419, 37309005
Carcinoma Non Small Cell Lung	Associate	32228656
Carcinoma Renal Cell	Associate	36710419
Carcinoma Squamous Cell	Associate	39237897
COVID 19	Associate	37309005
Endometrial Neoplasms	Associate	36710419
Lymphoma Non Hodgkin	Associate	37828118
Neoplasm Metastasis	Stimulate	24344117
Neoplasms	Associate	26678035, 28423514, 30910840, 35489022, 35650627, 36710419
Neoplasms	Stimulate	28078827, 33747255
Ovarian Neoplasms	Associate	35489022
Pancreatic Neoplasms	Associate	36710419
Thrombosis	Associate	26125229

FAM83D (family with sequence similarity 83 member D)