PLA2G12A (phospholipase A2 group XIIA)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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81579 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Phospholipase A2 group XIIA |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PLA2G12A |
Synonyms (NCBI Gene)
Gene synonyms aliases
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GXII, PLA2G12, ROSSY |
Chromosome
Chromosome number
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4 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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4q25 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and a |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q9BZM1 | ||||||||||
Protein name | Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A) | ||||||||||
Protein function | PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine. {ECO:0000269|PubMed:1252 | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas. | ||||||||||
Sequence |
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Sequence length | 189 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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