Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
81579
Gene name Gene Name - the full gene name approved by the HGNC.
Phospholipase A2 group XIIA
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PLA2G12A
Synonyms (NCBI Gene) Gene synonyms aliases
GXII, PLA2G12, ROSSY
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q25
Summary Summary of gene provided in NCBI Entrez Gene.
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and a
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT040676 hsa-miR-92b-3p CLASH 23622248
MIRT635956 hsa-miR-216a-5p HITS-CLIP 23824327
MIRT675723 hsa-miR-4519 HITS-CLIP 23824327
MIRT635955 hsa-miR-130a-3p HITS-CLIP 23824327
MIRT635954 hsa-miR-130b-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004623 Function Phospholipase A2 activity IBA 21873635
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 32814053
GO:0005576 Component Extracellular region NAS 11031251
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611652 18554 ENSG00000123739
Protein
UniProt ID Q9BZM1
Protein name Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)
Protein function PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine. {ECO:0000269|PubMed:1252
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06951 PLA2G12 14 189 Group XII secretory phospholipase A2 precursor (PLA2G12) Domain
Tissue specificity TISSUE SPECIFICITY: Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.
Sequence
Sequence length 189
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorption
  Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Age-related macular degeneration Age related macular degeneration rs199474657, rs61750120, rs1800728, rs62654397, rs61749423, rs61751412, rs61749439, rs61751398, rs61752417, rs62645946, rs1801269, rs62646860, rs61750142, rs61750145, rs61750152
View all (20 more)
20385819
Associations from Text Mining
Disease Name Relationship Type References
Colorectal Neoplasms Stimulate 20459617
Insulin Resistance Associate 39277575
Macular Degeneration Associate 23112570
Myocardial Infarction Associate 36863716