TMX1 (thioredoxin related transmembrane protein 1)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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81542 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Thioredoxin related transmembrane protein 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TMX1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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PDIA11, TMX, TXNDC, TXNDC1 |
Chromosome
Chromosome number
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14 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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14q22.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically ac |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q9H3N1 | ||||||||||
Protein name | Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein) | ||||||||||
Protein function | Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:11152479, PubMed:37648867). | ||||||||||
PDB | 1X5E | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Ubiquitous (PubMed:11152479). Highly expressed in kidney, liver, placenta and lung (PubMed:11152479). {ECO:0000269|PubMed:11152479}. | ||||||||||
Sequence |
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Sequence length | 280 | ||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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