Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
81542
Gene name Gene Name - the full gene name approved by the HGNC.
Thioredoxin related transmembrane protein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TMX1
Synonyms (NCBI Gene) Gene synonyms aliases
PDIA11, TMX, TXNDC, TXNDC1
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically ac
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005279 hsa-miR-1-3p pSILAC 18668040
MIRT005279 hsa-miR-1-3p Proteomics;Other 18668040
MIRT341525 hsa-miR-4517 PAR-CLIP 22100165
MIRT442938 hsa-miR-513b-3p PAR-CLIP 22100165
MIRT442937 hsa-miR-3163 PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183, 32814053
GO:0005789 Component Endoplasmic reticulum membrane IDA 11152479
GO:0015036 Function Disulfide oxidoreductase activity IDA 11152479, 22228764
GO:0016021 Component Integral component of membrane IEA
GO:0034976 Process Response to endoplasmic reticulum stress IMP 11152479
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610527 15487 ENSG00000139921
Protein
UniProt ID Q9H3N1
Protein name Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein)
Protein function Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:11152479, PubMed:37648867).
PDB 1X5E
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00085 Thioredoxin 30 129 Thioredoxin Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous (PubMed:11152479). Highly expressed in kidney, liver, placenta and lung (PubMed:11152479). {ECO:0000269|PubMed:11152479}.
Sequence
MAPSGSLAVPLAVLVLLLWGAPWTHGRRSNVRVITDENWRELLEGDWMIEFYAPWCPACQ
NLQPEWESFAEWGEDLEVNIAKVDVTEQPGLSGRFIITALPTIYHCKDGEFRRYQGPRTK
KDFINFISD
KEWKSIEPVSSWFGPGSVLMSSMSALFQLSMWIRTCHNYFIEDLGLPVWGS
YTVFALATLFSGLLLGLCMIFVADCLCPSKRRRPQPYPYPSKKLLSESAQPLKKVEEEQE
ADEEDVSEEEAESKEGTNKDFPQNAIRQRSLGPSLATDKS
Sequence length 280
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinogenesis Associate 36106447
Carcinoma Hepatocellular Associate 38147024
Carcinoma Renal Cell Associate 38147024
Glioma Associate 36106447
Immune System Diseases Associate 38147024
Neoplasms Associate 38147024