TMX1 (thioredoxin related transmembrane protein 1)
| Gene | |
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
81542 |
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Thioredoxin related transmembrane protein 1 |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
TMX1 |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
|
PDIA11, TMX, TXNDC, TXNDC1 |
|
Chromosome
Chromosome number
|
14 |
|
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
14q22.1 |
|
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically ac |
|
miRNA
miRNA information provided by mirtarbase database.
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|||||||
|
|||||||
| Protein | |||||||||||
| UniProt ID | Q9H3N1 | ||||||||||
| Protein name | Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein) | ||||||||||
| Protein function | Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (PubMed:11152479, PubMed:37648867). | ||||||||||
| PDB | 1X5E | ||||||||||
| Family and domains |
Pfam
|
||||||||||
| Tissue specificity | TISSUE SPECIFICITY: Ubiquitous (PubMed:11152479). Highly expressed in kidney, liver, placenta and lung (PubMed:11152479). {ECO:0000269|PubMed:11152479}. | ||||||||||
| Sequence |
|
||||||||||
| Sequence length | 280 | ||||||||||
| Interactions | View interactions | ||||||||||
|
Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||