TCL1A (TCL1 family AKT coactivator A)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8115
Gene name Gene Name - the full gene name approved by the HGNC.
TCL1 family AKT coactivator A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TCL1A
Synonyms (NCBI Gene) Gene synonyms aliases
TCL1
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.13
Summary Summary of gene provided in NCBI Entrez Gene.
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(34)
miRTarBase ID miRNA Experiments Reference
MIRT004510 hsa-miR-29b-3p Luciferase reporter assay 17707831
MIRT004510 hsa-miR-29b-3p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 17178851
MIRT005106 hsa-miR-181b-5p Luciferase reporter assay, Microarray, qRT-PCR, Western blot 17178851
MIRT005106 hsa-miR-181b-5p Western blot 17178851
MIRT004510 hsa-miR-29b-3p Western blot 17178851
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(19)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16189514, 16934922, 19064921, 21516116, 25416956, 25910212, 26871637, 27107012, 29997244, 31515488, 32296183
GO:0005654 Component Nucleoplasm IDA
GO:0005783 Component Endoplasmic reticulum IDA
GO:0005829 Component Cytosol IDA
GO:0007275 Process Multicellular organism development TAS 7809072
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
186960 11648 ENSG00000100721
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P56279
Protein name T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)
Protein function Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. {ECO:0000269|PubMed:10716693, ECO:00
PDB 1JSG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01840 TCL1_MTCP1 1 → 112 TCL1/MTCP1 family Family
Tissue specificity TISSUE SPECIFICITY: Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
Sequence
Sequence length 114
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  PI3K-Akt signaling pathway  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Lymphoblastic leukemia Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-cell acute lymphoblastic leukemia rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699
View all (13 more)
Show/Hide Text Mining Associations (72)
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 11304575
Ataxia Telangiectasia Associate 11752899, 12966431, 8415691
Ataxia Telangiectasia Stimulate 7662982
Bone Marrow Diseases Associate 29449683
Bone Neoplasms Associate 23199169
Breast Neoplasms Associate 22405131, 37684436
Burkitt Lymphoma Associate 18820675, 29318382
Carcinoma Renal Cell Associate 11752899
Cardiovascular Diseases Associate 36505471
Cholangiocarcinoma Associate 37234171