Gene Gene information from NCBI Gene database.
Entrez ID 80854
Gene name SET domain containing 7, histone lysine methyltransferase
Gene symbol SETD7
Synonyms (NCBI Gene)
KMT7SET7SET7/9SET9
Chromosome 4
Chromosome location 4q31.1
miRNA miRNA information provided by mirtarbase database.
1230
miRTarBase ID miRNA Experiments Reference
MIRT016229 hsa-miR-590-3p Sequencing 20371350
MIRT019502 hsa-miR-151a-3p Sequencing 20371350
MIRT020048 hsa-miR-375 Microarray 20215506
MIRT022071 hsa-miR-128-3p Microarray 17612493
MIRT028334 hsa-miR-32-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0002039 Function P53 binding IPI 17108971
GO:0003682 Function Chromatin binding IEA
GO:0005515 Function Protein binding IPI 12540855, 15525938, 16415881, 17108971, 17805299, 19262565, 19282482, 19864627, 21119616, 21131967, 21151116, 21245319, 21988832, 22345554, 22402663
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606594 30412 ENSG00000145391
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8WTS6
Protein name Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9)
Protein function Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12540855, PubMed:12588998, PubMed:16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcription
PDB 1H3I , 1MT6 , 1MUF , 1N6A , 1N6C , 1O9S , 1XQH , 2F69 , 3CBM , 3CBO , 3CBP , 3M53 , 3M54 , 3M55 , 3M56 , 3M57 , 3M58 , 3M59 , 3M5A , 3OS5 , 3VUZ , 3VV0 , 4E47 , 4J7F , 4J7I , 4J83 , 4J8O , 4JDS , 4JLG , 5AYF , 5EG2 , 5YLT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02493 MORN 13 35 MORN repeat Repeat
PF02493 MORN 36 58 MORN repeat Repeat
PF02493 MORN 60 81 MORN repeat Repeat
PF02493 MORN 106 128 MORN repeat Repeat
PF00856 SET 170 336 SET domain Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed in pancreatic islets. {ECO:0000269|PubMed:16141209}.
Sequence
Sequence length 366
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Lysine degradation
Metabolic pathways
FoxO signaling pathway
  PKMTs methylate histone lysines
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COGNITION DISORDERS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DELIRIUM, DEMENTIA, AMNESTIC, COGNITIVE DISORDERS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma of Lung Associate 37682707
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 18471979, 32102992
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 32126149
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 16441421, 27183310, 30106440
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Inhibit 37682707
★☆☆☆☆
Found in Text Mining only
Clinical Deterioration Inhibit 26701885
★☆☆☆☆
Found in Text Mining only
Colonic Polyps Stimulate 30361067
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 16441421, 30361067
★☆☆☆☆
Found in Text Mining only
DNA Virus Infections Associate 26317544
★☆☆☆☆
Found in Text Mining only
Glioma Associate 33336743
★☆☆☆☆
Found in Text Mining only