Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
80854
Gene name Gene Name - the full gene name approved by the HGNC.
SET domain containing 7, histone lysine methyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SETD7
Synonyms (NCBI Gene) Gene synonyms aliases
KMT7, SET7, SET7/9, SET9
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q31.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016229 hsa-miR-590-3p Sequencing 20371350
MIRT019502 hsa-miR-151a-3p Sequencing 20371350
MIRT020048 hsa-miR-375 Microarray 20215506
MIRT022071 hsa-miR-128-3p Microarray 17612493
MIRT028334 hsa-miR-32-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002039 Function P53 binding IPI 17108971
GO:0003682 Function Chromatin binding IEA
GO:0005515 Function Protein binding IPI 12540855, 15525938, 16415881, 17108971, 17805299, 19262565, 19282482, 19864627, 21119616, 21131967, 21151116, 21245319, 21988832, 22345554, 22402663
GO:0005654 Component Nucleoplasm TAS
GO:0005694 Component Chromosome IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606594 30412 ENSG00000145391
Protein
UniProt ID Q8WTS6
Protein name Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9)
Protein function Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12540855, PubMed:12588998, PubMed:16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcription
PDB 1H3I , 1MT6 , 1MUF , 1N6A , 1N6C , 1O9S , 1XQH , 2F69 , 3CBM , 3CBO , 3CBP , 3M53 , 3M54 , 3M55 , 3M56 , 3M57 , 3M58 , 3M59 , 3M5A , 3OS5 , 3VUZ , 3VV0 , 4E47 , 4J7F , 4J7I , 4J83 , 4J8O , 4JDS , 4JLG , 5AYF , 5EG2 , 5YLT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02493 MORN 13 35 MORN repeat Repeat
PF02493 MORN 36 58 MORN repeat Repeat
PF02493 MORN 60 81 MORN repeat Repeat
PF02493 MORN 106 128 MORN repeat Repeat
PF00856 SET 170 336 SET domain Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed in pancreatic islets. {ECO:0000269|PubMed:16141209}.
Sequence
Sequence length 366
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Lysine degradation
Metabolic pathways
FoxO signaling pathway
  PKMTs methylate histone lysines
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Alzheimer`s Disease rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
26830138
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37682707
Breast Neoplasms Associate 18471979, 32102992
Carcinogenesis Associate 32126149
Carcinoma Hepatocellular Associate 16441421, 27183310, 30106440
Carcinoma Non Small Cell Lung Inhibit 37682707
Clinical Deterioration Inhibit 26701885
Colonic Polyps Stimulate 30361067
Colorectal Neoplasms Associate 16441421, 30361067
DNA Virus Infections Associate 26317544
Glioma Associate 33336743