UniProt ID |
Q8WTS6
|
Protein name |
Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9) |
Protein function |
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12540855, PubMed:12588998, PubMed:16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcription |
PDB |
1H3I
,
1MT6
,
1MUF
,
1N6A
,
1N6C
,
1O9S
,
1XQH
,
2F69
,
3CBM
,
3CBO
,
3CBP
,
3M53
,
3M54
,
3M55
,
3M56
,
3M57
,
3M58
,
3M59
,
3M5A
,
3OS5
,
3VUZ
,
3VV0
,
4E47
,
4J7F
,
4J7I
,
4J83
,
4J8O
,
4JDS
,
4JLG
,
5AYF
,
5EG2
,
5YLT
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF02493
|
MORN |
13 → 35 |
MORN repeat |
Repeat |
PF02493
|
MORN |
36 → 58 |
MORN repeat |
Repeat |
PF02493
|
MORN |
60 → 81 |
MORN repeat |
Repeat |
PF02493
|
MORN |
106 → 128 |
MORN repeat |
Repeat |
PF00856
|
SET |
170 → 336 |
SET domain |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Widely expressed. Expressed in pancreatic islets. {ECO:0000269|PubMed:16141209}. |
Sequence |
|
Sequence length |
366 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Alzheimer disease |
Alzheimer`s Disease |
rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316 View all (65 more) |
26830138 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Metabolic Syndrome |
Metabolic Syndrome |
|
|
GWAS |
Schizophrenia |
Schizophrenia |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma of Lung |
Associate
|
37682707 |
Breast Neoplasms |
Associate
|
18471979, 32102992 |
Carcinogenesis |
Associate
|
32126149 |
Carcinoma Hepatocellular |
Associate
|
16441421, 27183310, 30106440 |
Carcinoma Non Small Cell Lung |
Inhibit
|
37682707 |
Clinical Deterioration |
Inhibit
|
26701885 |
Colonic Polyps |
Stimulate
|
30361067 |
Colorectal Neoplasms |
Associate
|
16441421, 30361067 |
DNA Virus Infections |
Associate
|
26317544 |
Glioma |
Associate
|
33336743 |
Leukemia |
Associate
|
28187429 |
Mesothelioma |
Associate
|
31570769 |
Multiple Myeloma |
Associate
|
23247593 |
Neoplasm Metastasis |
Associate
|
27183310, 33336743, 37286143 |
Neoplasms |
Inhibit
|
17646389, 26701885, 32126149, 37682707 |
Neoplasms |
Associate
|
25124555, 26317544, 30106440, 30361067, 32102992, 37286143 |
Peritonitis |
Associate
|
31570769 |
Personality Disorders |
Inhibit
|
26701885 |
Prostatic Neoplasms |
Associate
|
20959290, 25189356, 26861389 |
Prostatitis |
Associate
|
37870957 |
Pulmonary Disease Chronic Obstructive |
Associate
|
26251585 |
Stomach Neoplasms |
Inhibit
|
26701885 |
Stomach Neoplasms |
Associate
|
33336743 |
Triple Negative Breast Neoplasms |
Stimulate
|
37286143 |
Urinary Bladder Neoplasms |
Associate
|
32126149 |
|