Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
80824
Gene name Gene Name - the full gene name approved by the HGNC.
Dual specificity phosphatase 16
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DUSP16
Synonyms (NCBI Gene) Gene synonyms aliases
MKP-7, MKP7
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphoty
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016920 hsa-miR-335-5p Microarray 18185580
MIRT026190 hsa-miR-192-5p Microarray 19074876
MIRT447127 hsa-miR-606 PAR-CLIP 22100165
MIRT447126 hsa-miR-4318 PAR-CLIP 22100165
MIRT447125 hsa-miR-892a PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000188 Process Inactivation of MAPK activity IBA 21873635
GO:0000188 Process Inactivation of MAPK activity TAS 11489891
GO:0004721 Function Phosphoprotein phosphatase activity IBA 21873635
GO:0004721 Function Phosphoprotein phosphatase activity TAS 11489891
GO:0004725 Function Protein tyrosine phosphatase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607175 17909 ENSG00000111266
Protein
UniProt ID Q9BY84
Protein name Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7)
Protein function Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
PDB 2VSW , 3TG3 , 4YR8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00581 Rhodanese 11 131 Rhodanese-like domain Domain
PF00782 DSPc 166 297 Dual specificity phosphatase, catalytic domain Domain
Sequence
MAHEMIGTQIVTERLVALLESGTEKVLLIDSRPFVEYNTSHILEAININCSKLMKRRLQQ
DKVLITELIQHSAKHKVDIDCSQKVVVYDQSSQDVASLSSDCFLTVLLGKLEKSFNSVHL
LAGGFAEFSRC
FPGLCEGKSTLVPTCISQPCLPVANIGPTRILPNLYLGCQRDVLNKELM
QQNGIGYVLNASNTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCV
LVHCLAGISRSATIAIAYIMKRMDMSLDEAYRFVKEKRPTISPNFNFLGQLLDYEKK
IKN
QTGASGPKSKLKLLHLEKPNEPVPAVSEGGQKSETPLSPPCADSATSEAAGQRPVHPASV
PSVPSVQPSLLEDSPLVQALSGLHLSADRLEDSNKLKRSFSLDIKSVSYSASMAASLHGF
SSSEDALEYYKPSTTLDGTNKLCQFSPVQELSEQTPETSPDKEEASIPKKLQTARPSDSQ
SKRLHSVRTSSSGTAQRSLLSPLHRSGSVEDNYHTSFLFGLSTSQQHLTKSAGLGLKGWH
SDILAPQTSTPSLTSSWYFATESSHFYSASAIYGGSASYSAYSCSQLPTCGDQVYSVRRR
QKPSDRADSRRSWHEESPFEKQFKRRSCQMEFGESIMSENRSREELGKVGSQSSFSGSME
IIEVS
Sequence length 665
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Efferocytosis
  RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway
Suppression of autophagy
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Inflammatory bowel disease Inflammatory Bowel Diseases rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468 23128233
Unknown
Disease term Disease name Evidence References Source
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Pelvic Organ Prolapse Pelvic Organ Prolapse GWAS
Ulcerative colitis Ulcerative colitis GWAS
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 31357550
Breast Neoplasms Inhibit 34275890
Burkitt Lymphoma Associate 20551953
Carcinogenesis Associate 26381291
Carcinoma Hepatocellular Stimulate 26381291
Infections Associate 29167762
Inflammatory Bowel Diseases Associate 34758847
Leukemia Lymphocytic Chronic B Cell Associate 37792532
Leukemia Myeloid Acute Associate 25213837
Melanoma Associate 35999349