Gene Gene information from NCBI Gene database.
Entrez ID 8073
Gene name Protein tyrosine phosphatase 4A2
Gene symbol PTP4A2
Synonyms (NCBI Gene)
HH13HH7-2HU-PP-1OV-1PRL-2PRL2PTP4APTPCAAX2ptp-IV1aptp-IV1b
Chromosome 1
Chromosome location 1p35.2
Summary The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phos
miRNA miRNA information provided by mirtarbase database.
990
miRTarBase ID miRNA Experiments Reference
MIRT019880 hsa-miR-375 Microarray 20215506
MIRT021519 hsa-miR-145-5p Reporter assay;Microarray 21351259
MIRT022621 hsa-miR-124-3p Microarray 18668037
MIRT025801 hsa-miR-7-5p Sequencing 20371350
MIRT052212 hsa-let-7b-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity IBA
GO:0004725 Function Protein tyrosine phosphatase activity IEA
GO:0004725 Function Protein tyrosine phosphatase activity TAS 9514946
GO:0004857 Function Enzyme inhibitor activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601584 9635 ENSG00000184007
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q12974
Protein name Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2)
Protein function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. {ECO:0000269|PubMed:146
PDB 5K22 , 5K23 , 5K25 , 6WUR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00102 Y_phosphatase 11 149 Protein-tyrosine phosphatase Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue. {ECO:0000269|PubMed:10940933, ECO:0000269|PubMed:11734337, ECO:0000269|PubMed:8661118}.
Sequence
Sequence length 167
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RAB geranylgeranylation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
HEART FAILURE, DIASTOLIC CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Breast Neoplasms Associate 20413845, 23568563, 39665584
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 34992672
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Associate 35812454
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 25193986
★☆☆☆☆
Found in Text Mining only
Hodgkin Disease Associate 12865944
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Associate 21765462
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Associate 21765462
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 21765462, 39665584
★☆☆☆☆
Found in Text Mining only
Neoplasms Inhibit 32861966
★☆☆☆☆
Found in Text Mining only
Ovarian Neoplasms Associate 21541048
★☆☆☆☆
Found in Text Mining only