PTP4A2 (protein tyrosine phosphatase 4A2)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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8073 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Protein tyrosine phosphatase 4A2 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PTP4A2 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
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HH13 |
Chromosome
Chromosome number
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1 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1p35.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phos |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q12974 | ||||||||||
Protein name | Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) | ||||||||||
Protein function | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. {ECO:0000269|PubMed:146 | ||||||||||
PDB | 5K22 , 5K23 , 5K25 , 6WUR | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue. {ECO:0000269|PubMed:10940933, ECO:0000269|PubMed:11734337, ECO:0000269|PubMed:8661118}. | ||||||||||
Sequence |
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Sequence length | 167 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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