Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8073
Gene name Gene Name - the full gene name approved by the HGNC.
Protein tyrosine phosphatase 4A2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PTP4A2
Synonyms (NCBI Gene) Gene synonyms aliases
HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HH13
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p35.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phos
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019880 hsa-miR-375 Microarray 20215506
MIRT021519 hsa-miR-145-5p Reporter assay;Microarray 21351259
MIRT022621 hsa-miR-124-3p Microarray 18668037
MIRT025801 hsa-miR-7-5p Sequencing 20371350
MIRT052212 hsa-let-7b-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004725 Function Protein tyrosine phosphatase activity IBA 21873635
GO:0004727 Function Prenylated protein tyrosine phosphatase activity TAS 9514946
GO:0005515 Function Protein binding IPI 28330616, 32296183
GO:0005634 Component Nucleus IBA 21873635
GO:0005737 Component Cytoplasm IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601584 9635 ENSG00000184007
Protein
UniProt ID Q12974
Protein name Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2)
Protein function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. {ECO:0000269|PubMed:146
PDB 5K22 , 5K23 , 5K25 , 6WUR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00102 Y_phosphatase 11 149 Protein-tyrosine phosphatase Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue. {ECO:0000269|PubMed:10940933, ECO:0000269|PubMed:11734337, ECO:0000269|PubMed:8661118}.
Sequence
Sequence length 167
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    RAB geranylgeranylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Heart failure Heart Failure, Diastolic 29556499 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 20413845, 23568563, 39665584
Carcinoma Hepatocellular Associate 34992672
Carcinoma Renal Cell Associate 35812454
Colorectal Neoplasms Associate 25193986
Hodgkin Disease Associate 12865944
Lung Neoplasms Associate 21765462
Neoplasm Metastasis Associate 21765462
Neoplasms Associate 21765462, 39665584
Neoplasms Inhibit 32861966
Ovarian Neoplasms Associate 21541048