Gene Gene information from NCBI Gene database.
Entrez ID 80381
Gene name CD276 molecule
Gene symbol CD276
Synonyms (NCBI Gene)
4Ig-B7-H3B7-H3B7H3B7RP-2
Chromosome 15
Chromosome location 15q24.1
Summary The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues an
miRNA miRNA information provided by mirtarbase database.
243
miRTarBase ID miRNA Experiments Reference
MIRT003343 hsa-miR-29a-3p Review 20026422
MIRT004631 hsa-miR-29c-3p Review 20026422
MIRT003343 hsa-miR-29a-3p Luciferase reporter assayWestern blot 19584290
MIRT003343 hsa-miR-29a-3p Luciferase reporter assayWestern blot 19584290
MIRT018004 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0001817 Process Regulation of cytokine production IBA
GO:0001819 Process Positive regulation of cytokine production IEA
GO:0005102 Function Signaling receptor binding IBA
GO:0005102 Function Signaling receptor binding NAS 11224528
GO:0005515 Function Protein binding IPI 18650384
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605715 19137 ENSG00000103855
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5ZPR3
Protein name CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)
Protein function May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 32 138 Immunoglobulin V-set domain Domain
PF13927 Ig_3 144 224 Domain
PF07686 V-set 250 356 Immunoglobulin V-set domain Domain
PF13927 Ig_3 362 442 Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in
Sequence
Sequence length 534
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Cell adhesion molecules  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
15
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
3 methylcrotonyl CoA carboxylase 1 deficiency Associate 30808776
★☆☆☆☆
Found in Text Mining only
Abortion Habitual Inhibit 37685876
★☆☆☆☆
Found in Text Mining only
Acute erythroleukemia Stimulate 26376842
★☆☆☆☆
Found in Text Mining only
Acute erythroleukemia Associate 34562306
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Associate 17686830
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of Lung Associate 26851185, 33426073, 34419075, 35590371, 38177255
★☆☆☆☆
Found in Text Mining only
Adenoma Associate 16489649
★☆☆☆☆
Found in Text Mining only
Adenomyosis Associate 34289871
★☆☆☆☆
Found in Text Mining only
Adrenocortical Carcinoma Associate 31998416, 34194394
★☆☆☆☆
Found in Text Mining only
Aicardi Syndrome Associate 31998416
★☆☆☆☆
Found in Text Mining only