Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
80381
Gene name Gene Name - the full gene name approved by the HGNC.
CD276 molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CD276
Synonyms (NCBI Gene) Gene synonyms aliases
4Ig-B7-H3, B7-H3, B7H3, B7RP-2
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q24.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues an
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003343 hsa-miR-29a-3p Review 20026422
MIRT004631 hsa-miR-29c-3p Review 20026422
MIRT003343 hsa-miR-29a-3p Luciferase reporter assay, Western blot 19584290
MIRT003343 hsa-miR-29a-3p Luciferase reporter assay, Western blot 19584290
MIRT018004 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001817 Process Regulation of cytokine production IBA 21873635
GO:0005102 Function Signaling receptor binding IBA 21873635
GO:0005102 Function Signaling receptor binding NAS 11224528
GO:0005515 Function Protein binding IPI 18650384
GO:0009897 Component External side of plasma membrane IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605715 19137 ENSG00000103855
Protein
UniProt ID Q5ZPR3
Protein name CD276 antigen (4Ig-B7-H3) (B7 homolog 3) (B7-H3) (Costimulatory molecule) (CD antigen CD276)
Protein function May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 32 138 Immunoglobulin V-set domain Domain
PF13927 Ig_3 144 224 Domain
PF07686 V-set 250 356 Immunoglobulin V-set domain Domain
PF13927 Ig_3 362 442 Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in
Sequence
Sequence length 534
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Cell adhesion molecules  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 30614027
Unknown
Disease term Disease name Evidence References Source
Bipolar Disorder Bipolar Disorder GWAS
Mental Depression Mental Depression GWAS
Tourette Syndrome Tourette Syndrome GWAS
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
3 methylcrotonyl CoA carboxylase 1 deficiency Associate 30808776
Abortion Habitual Inhibit 37685876
Acute erythroleukemia Stimulate 26376842
Acute erythroleukemia Associate 34562306
Adenocarcinoma Associate 17686830
Adenocarcinoma of Lung Associate 26851185, 33426073, 34419075, 35590371, 38177255
Adenoma Associate 16489649
Adenomyosis Associate 34289871
Adrenocortical Carcinoma Associate 31998416, 34194394
Aicardi Syndrome Associate 31998416