Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	80380
Gene name Gene Name - the full gene name approved by the HGNC.	Programmed cell death 1 ligand 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PDCD1LG2
Synonyms (NCBI Gene) Gene synonyms aliases	B7DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2, bA574F11.2
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9p24.1

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miRTarBase ID	miRNA	Experiments
MIRT1219241	hsa-miR-106a	CLIP-seq
MIRT1219242	hsa-miR-106b	CLIP-seq
MIRT1219243	hsa-miR-142-5p	CLIP-seq
MIRT1219244	hsa-miR-17	CLIP-seq
MIRT1219245	hsa-miR-186	CLIP-seq
MIRT1219246	hsa-miR-199a-3p	CLIP-seq
MIRT1219247	hsa-miR-199b-3p	CLIP-seq
MIRT1219248	hsa-miR-20a	CLIP-seq
MIRT1219249	hsa-miR-20b	CLIP-seq
MIRT1219250	hsa-miR-2113	CLIP-seq
MIRT1219251	hsa-miR-3129-5p	CLIP-seq
MIRT1219252	hsa-miR-3133	CLIP-seq
MIRT1219253	hsa-miR-3145-5p	CLIP-seq
MIRT1219254	hsa-miR-340	CLIP-seq
MIRT1219255	hsa-miR-3607-3p	CLIP-seq
MIRT1219256	hsa-miR-3609	CLIP-seq
MIRT1219257	hsa-miR-3686	CLIP-seq
MIRT1219258	hsa-miR-3925-3p	CLIP-seq
MIRT1219259	hsa-miR-4275	CLIP-seq
MIRT1219260	hsa-miR-4473	CLIP-seq
MIRT1219261	hsa-miR-4712-5p	CLIP-seq
MIRT1219262	hsa-miR-4778-5p	CLIP-seq
MIRT1219263	hsa-miR-4796-3p	CLIP-seq
MIRT1219264	hsa-miR-508-5p	CLIP-seq
MIRT1219265	hsa-miR-512-3p	CLIP-seq
MIRT1219266	hsa-miR-519a	CLIP-seq
MIRT1219267	hsa-miR-519b-3p	CLIP-seq
MIRT1219268	hsa-miR-519c-3p	CLIP-seq
MIRT1219269	hsa-miR-519d	CLIP-seq
MIRT1219270	hsa-miR-520f	CLIP-seq
MIRT1219271	hsa-miR-548ah	CLIP-seq
MIRT1219272	hsa-miR-577	CLIP-seq
MIRT1219273	hsa-miR-618	CLIP-seq
MIRT1219274	hsa-miR-770-5p	CLIP-seq
MIRT1219275	hsa-miR-93	CLIP-seq
MIRT1219241	hsa-miR-106a	CLIP-seq
MIRT1219242	hsa-miR-106b	CLIP-seq
MIRT1219244	hsa-miR-17	CLIP-seq
MIRT1219246	hsa-miR-199a-3p	CLIP-seq
MIRT1219247	hsa-miR-199b-3p	CLIP-seq
MIRT1219248	hsa-miR-20a	CLIP-seq
MIRT1219249	hsa-miR-20b	CLIP-seq
MIRT1219251	hsa-miR-3129-5p	CLIP-seq
MIRT1219255	hsa-miR-3607-3p	CLIP-seq
MIRT1219256	hsa-miR-3609	CLIP-seq
MIRT1219257	hsa-miR-3686	CLIP-seq
MIRT1219260	hsa-miR-4473	CLIP-seq
MIRT1219262	hsa-miR-4778-5p	CLIP-seq
MIRT1219263	hsa-miR-4796-3p	CLIP-seq
MIRT1219265	hsa-miR-512-3p	CLIP-seq
MIRT1219266	hsa-miR-519a	CLIP-seq
MIRT1219267	hsa-miR-519b-3p	CLIP-seq
MIRT1219268	hsa-miR-519c-3p	CLIP-seq
MIRT1219269	hsa-miR-519d	CLIP-seq
MIRT1219270	hsa-miR-520f	CLIP-seq
MIRT1219271	hsa-miR-548ah	CLIP-seq
MIRT1219275	hsa-miR-93	CLIP-seq
MIRT1219241	hsa-miR-106a	CLIP-seq
MIRT1219242	hsa-miR-106b	CLIP-seq
MIRT1219244	hsa-miR-17	CLIP-seq
MIRT1219248	hsa-miR-20a	CLIP-seq
MIRT1219249	hsa-miR-20b	CLIP-seq
MIRT1219256	hsa-miR-3609	CLIP-seq
MIRT1219262	hsa-miR-4778-5p	CLIP-seq
MIRT1219263	hsa-miR-4796-3p	CLIP-seq
MIRT1219269	hsa-miR-519d	CLIP-seq
MIRT1219271	hsa-miR-548ah	CLIP-seq
MIRT1219275	hsa-miR-93	CLIP-seq
MIRT1219250	hsa-miR-2113	CLIP-seq
MIRT1219253	hsa-miR-3145-5p	CLIP-seq
MIRT2589537	hsa-miR-3591-5p	CLIP-seq
MIRT2589538	hsa-miR-3613-3p	CLIP-seq
MIRT2589539	hsa-miR-3684	CLIP-seq
MIRT2589540	hsa-miR-371b-5p	CLIP-seq
MIRT2589541	hsa-miR-4280	CLIP-seq
MIRT2589542	hsa-miR-4325	CLIP-seq
MIRT1219264	hsa-miR-508-5p	CLIP-seq
MIRT1219253	hsa-miR-3145-5p	CLIP-seq
MIRT2589538	hsa-miR-3613-3p	CLIP-seq
MIRT2589539	hsa-miR-3684	CLIP-seq
MIRT2589540	hsa-miR-371b-5p	CLIP-seq
MIRT1219264	hsa-miR-508-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	20587542, 23417675, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IBA
GO:0006955	Process	Immune response	NAS	11283156
GO:0007166	Process	Cell surface receptor signaling pathway	IBA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0031295	Process	T cell costimulation	IBA
GO:0032689	Process	Negative regulation of type II interferon production	IMP	12538684
GO:0032693	Process	Negative regulation of interleukin-10 production	IMP	12538684
GO:0042102	Process	Positive regulation of T cell proliferation	IBA
GO:0042102	Process	Positive regulation of T cell proliferation	IEA
GO:0042130	Process	Negative regulation of T cell proliferation	IBA
GO:0042130	Process	Negative regulation of T cell proliferation	IEA
GO:0042130	Process	Negative regulation of T cell proliferation	IEA
GO:0046007	Process	Negative regulation of activated T cell proliferation	IMP	12538684
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA

MIM	HGNC	e!Ensembl
605723	18731	ENSG00000197646

Protein

UniProt ID

Q9BQ51

Protein name

Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)

Protein function

Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By simil

PDB

6UMT , 8J3V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13927	Ig_3	22 → 105		Domain
PF08205	C2-set_2	125 → 202	CD80-like C2-set immunoglobulin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus. {ECO:0000269|PubMed:11224527}.

Sequence

MIFLLLMLSLELQLHQIAALFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQ
KVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVK
ASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVL
RLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPTWLLHIFIPFCIIAFIFIATV
IALRKQLCQKLYSSKDTTKRPVTTTKREVNSAI

Sequence length

273

Interactions

View interactions

	KEGG		Reactome
	Cell adhesion molecules		PD-1 signaling

PDCD1LG2 (programmed cell death 1 ligand 2)