Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
80351
Gene name Gene Name - the full gene name approved by the HGNC.
Tankyrase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TNKS2
Synonyms (NCBI Gene) Gene synonyms aliases
ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, TANK2, TNKL, pART6
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q23.32
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018499 hsa-miR-335-5p Microarray 18185580
MIRT046944 hsa-miR-221-3p CLASH 23622248
MIRT044139 hsa-miR-30e-5p CLASH 23622248
MIRT039255 hsa-miR-454-5p CLASH 23622248
MIRT038941 hsa-miR-31-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000209 Process Protein polyubiquitination IDA 19759537, 21478859
GO:0000242 Component Pericentriolar material IDA 11454873
GO:0000781 Component Chromosome, telomeric region IC 11739745
GO:0003950 Function NAD+ ADP-ribosyltransferase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607128 15677 ENSG00000107854
Protein
UniProt ID Q9H2K2
Protein name Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP
Protein function Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an a
PDB 2Y0I , 3KR7 , 3KR8 , 3MHJ , 3MHK , 3P0N , 3P0P , 3P0Q , 3TWQ , 3TWR , 3TWS , 3TWT , 3TWU , 3TWV , 3TWW , 3TWX , 3U9H , 3U9Y , 3UA9 , 3W51 , 4AVU , 4AVW , 4BFP , 4BJ9 , 4BJB , 4BJC , 4BS4 , 4BU3 , 4BU5 , 4BU6 , 4BU7 , 4BU8 , 4BU9 , 4BUA , 4BUD , 4BUE , 4BUF , 4BUI , 4BUS , 4BUT , 4BUU , 4BUV , 4BUW , 4BUX , 4BUY , 4HKI , 4HKK , 4HKN , 4HL5 , 4HLF , 4HLG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12796 Ank_2 28 121 Ankyrin repeats (3 copies) Repeat
PF13857 Ank_5 77 131 Repeat
PF12796 Ank_2 181 274 Ankyrin repeats (3 copies) Repeat
PF13637 Ank_4 211 264 Repeat
PF00023 Ank 364 398 Ankyrin repeat Repeat
PF12796 Ank_2 398 463 Ankyrin repeats (3 copies) Repeat
PF13637 Ank_4 526 579 Repeat
PF12796 Ank_2 556 622 Ankyrin repeats (3 copies) Repeat
PF13637 Ank_4 679 732 Repeat
PF13857 Ank_5 735 785 Repeat
PF07647 SAM_2 872 934 SAM domain (Sterile alpha motif) Domain
PF00644 PARP 962 1157 Poly(ADP-ribose) polymerase catalytic domain Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast a
Sequence
MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKST
PLHFAAGFGRKDVVEY
LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR
D
NWNYTPLHEA
AIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDE
LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK
DKGDLVPLHNACSYGHYEVTELLV
KHGACVNAMD
LWQFTPLHEAASKNRVEVCSLLLSYG
ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH
PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV
KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIIS
LQGFTALQMGNENVQQL
LQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS
VVEYLLQHGADVHAK
DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA
AKGKYEICKLLLQHGADPTKKN
RDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR
VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA
SYGHVDVAALLI
KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQT
PLDLV
SADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASS
LDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQIT
LDVLVEMGHKELKEIGINAYGHRHKLIKGVERLI
SGQQGLNPYLTLNTSGSGTILIDLSP
DDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEEN
HNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTG
CPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYV
IYRGEQAYPEYLITYQI
MRPEGMVDG
Sequence length 1166
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    TCF dependent signaling in response to WNT
Degradation of AXIN
XAV939 inhibits tankyrase, stabilizing AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Non-Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
23945395
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 27485113
Cardiovascular Diseases Associate 20937264
Cerebral Infarction Associate 20937264
Colonic Neoplasms Stimulate 18026951
Colorectal Neoplasms Associate 33849554
Endometrial Neoplasms Associate 20549820
Glioblastoma Associate 32970185
Leukemia Myelogenous Chronic BCR ABL Positive Associate 36871092
Macular Degeneration Associate 36497103
Neoplasm Metastasis Stimulate 27485113