Gene Gene information from NCBI Gene database.
Entrez ID 80351
Gene name Tankyrase 2
Gene symbol TNKS2
Synonyms (NCBI Gene)
ARTD6PARP-5bPARP-5cPARP5BPARP5CTANK2TNKLpART6
Chromosome 10
Chromosome location 10q23.32
miRNA miRNA information provided by mirtarbase database.
625
miRTarBase ID miRNA Experiments Reference
MIRT018499 hsa-miR-335-5p Microarray 18185580
MIRT046944 hsa-miR-221-3p CLASH 23622248
MIRT044139 hsa-miR-30e-5p CLASH 23622248
MIRT039255 hsa-miR-454-5p CLASH 23622248
MIRT038941 hsa-miR-31-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
53
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000209 Process Protein polyubiquitination IDA 19759537, 21478859
GO:0000209 Process Protein polyubiquitination IEA
GO:0000242 Component Pericentriolar material IDA 11454873
GO:0000242 Component Pericentriolar material IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607128 15677 ENSG00000107854
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H2K2
Protein name Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP
Protein function Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an a
PDB 2Y0I , 3KR7 , 3KR8 , 3MHJ , 3MHK , 3P0N , 3P0P , 3P0Q , 3TWQ , 3TWR , 3TWS , 3TWT , 3TWU , 3TWV , 3TWW , 3TWX , 3U9H , 3U9Y , 3UA9 , 3W51 , 4AVU , 4AVW , 4BFP , 4BJ9 , 4BJB , 4BJC , 4BS4 , 4BU3 , 4BU5 , 4BU6 , 4BU7 , 4BU8 , 4BU9 , 4BUA , 4BUD , 4BUE , 4BUF , 4BUI , 4BUS , 4BUT , 4BUU , 4BUV , 4BUW , 4BUX , 4BUY , 4HKI , 4HKK , 4HKN , 4HL5 , 4HLF , 4HLG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12796 Ank_2 28 121 Ankyrin repeats (3 copies) Repeat
PF13857 Ank_5 77 131 Repeat
PF12796 Ank_2 181 274 Ankyrin repeats (3 copies) Repeat
PF13637 Ank_4 211 264 Repeat
PF00023 Ank 364 398 Ankyrin repeat Repeat
PF12796 Ank_2 398 463 Ankyrin repeats (3 copies) Repeat
PF13637 Ank_4 526 579 Repeat
PF12796 Ank_2 556 622 Ankyrin repeats (3 copies) Repeat
PF13637 Ank_4 679 732 Repeat
PF13857 Ank_5 735 785 Repeat
PF07647 SAM_2 872 934 SAM domain (Sterile alpha motif) Domain
PF00644 PARP 962 1157 Poly(ADP-ribose) polymerase catalytic domain Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast a
Sequence
MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKST
PLHFAAGFGRKDVVEY
LLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR
D
NWNYTPLHEA
AIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDE
LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK
DKGDLVPLHNACSYGHYEVTELLV
KHGACVNAMD
LWQFTPLHEAASKNRVEVCSLLLSYG
ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH
PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV
KHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIIS
LQGFTALQMGNENVQQL
LQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS
VVEYLLQHGADVHAK
DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA
AKGKYEICKLLLQHGADPTKKN
RDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR
VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA
SYGHVDVAALLI
KYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQT
PLDLV
SADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASS
LDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQIT
LDVLVEMGHKELKEIGINAYGHRHKLIKGVERLI
SGQQGLNPYLTLNTSGSGTILIDLSP
DDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEEN
HNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTG
CPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYV
IYRGEQAYPEYLITYQI
MRPEGMVDG
Sequence length 1166
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    TCF dependent signaling in response to WNT
Degradation of AXIN
XAV939 inhibits tankyrase, stabilizing AXIN
Ub-specific processing proteases
Regulation of PTEN stability and activity
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CIC-rearranged sarcoma not provided ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETIC KETOACIDOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Breast Neoplasms Associate 27485113
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Associate 20937264
★☆☆☆☆
Found in Text Mining only
Cerebral Infarction Associate 20937264
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Stimulate 18026951
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 33849554
★☆☆☆☆
Found in Text Mining only
Endometrial Neoplasms Associate 20549820
★☆☆☆☆
Found in Text Mining only
Glioblastoma Associate 32970185
★☆☆☆☆
Found in Text Mining only
Leukemia Myelogenous Chronic BCR ABL Positive Associate 36871092
★☆☆☆☆
Found in Text Mining only
Macular Degeneration Associate 36497103
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Stimulate 27485113
★☆☆☆☆
Found in Text Mining only