Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	8027
Gene name	Signal transducing adaptor molecule
Gene symbol	STAM
Synonyms (NCBI Gene)	STAM-1STAM1
Chromosome	10
Chromosome location	10p12.33
Summary	This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded pr

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Show/Hide all (238)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024512	hsa-miR-215-5p	Microarray	19074876
MIRT026819	hsa-miR-192-5p	Microarray	19074876
MIRT051525	hsa-let-7e-5p	CLASH	23622248
MIRT707233	hsa-miR-3617-5p	HITS-CLIP	21572407
MIRT707232	hsa-miR-641	HITS-CLIP	21572407
MIRT707231	hsa-miR-8485	HITS-CLIP	21572407
MIRT707230	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT707229	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT707228	hsa-miR-603	HITS-CLIP	21572407
MIRT707227	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT707226	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707225	hsa-miR-3675-3p	HITS-CLIP	21572407
MIRT177138	hsa-miR-3668	HITS-CLIP	21572407
MIRT707224	hsa-miR-130b-5p	HITS-CLIP	21572407
MIRT707223	hsa-miR-3935	HITS-CLIP	21572407
MIRT707222	hsa-miR-376a-2-5p	HITS-CLIP	21572407
MIRT707221	hsa-miR-3941	HITS-CLIP	21572407
MIRT707220	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707219	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707218	hsa-miR-4753-3p	HITS-CLIP	21572407
MIRT707217	hsa-miR-1277-3p	HITS-CLIP	21572407
MIRT707216	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT328236	hsa-miR-4635	PAR-CLIP	21572407
MIRT328237	hsa-miR-4670-3p	PAR-CLIP	21572407
MIRT544029	hsa-miR-4724-3p	PAR-CLIP	21572407
MIRT544028	hsa-miR-526b-5p	PAR-CLIP	21572407
MIRT328235	hsa-miR-3616-5p	PAR-CLIP	21572407
MIRT328233	hsa-miR-573	PAR-CLIP	21572407
MIRT544027	hsa-miR-578	PAR-CLIP	21572407
MIRT177133	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT177133	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT707233	hsa-miR-3617-5p	HITS-CLIP	21572407
MIRT707232	hsa-miR-641	HITS-CLIP	21572407
MIRT707231	hsa-miR-8485	HITS-CLIP	21572407
MIRT707230	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT707229	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT707228	hsa-miR-603	HITS-CLIP	21572407
MIRT707227	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT707226	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707225	hsa-miR-3675-3p	HITS-CLIP	21572407
MIRT177138	hsa-miR-3668	HITS-CLIP	21572407
MIRT707224	hsa-miR-130b-5p	HITS-CLIP	21572407
MIRT707223	hsa-miR-3935	HITS-CLIP	21572407
MIRT707222	hsa-miR-376a-2-5p	HITS-CLIP	21572407
MIRT707221	hsa-miR-3941	HITS-CLIP	21572407
MIRT707220	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707219	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707218	hsa-miR-4753-3p	HITS-CLIP	21572407
MIRT707217	hsa-miR-1277-3p	HITS-CLIP	21572407
MIRT707216	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT328236	hsa-miR-4635	PAR-CLIP	21572407
MIRT328237	hsa-miR-4670-3p	PAR-CLIP	21572407
MIRT544029	hsa-miR-4724-3p	PAR-CLIP	21572407
MIRT544028	hsa-miR-526b-5p	PAR-CLIP	21572407
MIRT328235	hsa-miR-3616-5p	PAR-CLIP	21572407
MIRT328233	hsa-miR-573	PAR-CLIP	21572407
MIRT544027	hsa-miR-578	PAR-CLIP	21572407
MIRT1394900	hsa-miR-3647-5p	CLIP-seq
MIRT1394901	hsa-miR-3653	CLIP-seq
MIRT1394902	hsa-miR-4328	CLIP-seq
MIRT1394903	hsa-miR-4733-5p	CLIP-seq
MIRT1394904	hsa-miR-4786-3p	CLIP-seq
MIRT1394905	hsa-miR-526b	CLIP-seq
MIRT1394906	hsa-miR-653	CLIP-seq
MIRT1394907	hsa-miR-885-5p	CLIP-seq
MIRT2118494	hsa-miR-197	CLIP-seq
MIRT2118495	hsa-miR-199a-3p	CLIP-seq
MIRT2118496	hsa-miR-199b-3p	CLIP-seq
MIRT2118497	hsa-miR-2277-3p	CLIP-seq
MIRT2118498	hsa-miR-2467-3p	CLIP-seq
MIRT2118499	hsa-miR-3129-5p	CLIP-seq
MIRT2118500	hsa-miR-3143	CLIP-seq
MIRT2118501	hsa-miR-329	CLIP-seq
MIRT2118502	hsa-miR-3617	CLIP-seq
MIRT1394900	hsa-miR-3647-5p	CLIP-seq
MIRT2118503	hsa-miR-3658	CLIP-seq
MIRT2118504	hsa-miR-3678-3p	CLIP-seq
MIRT2118505	hsa-miR-3975	CLIP-seq
MIRT1394902	hsa-miR-4328	CLIP-seq
MIRT2118506	hsa-miR-4676-5p	CLIP-seq
MIRT2118507	hsa-miR-4679	CLIP-seq
MIRT2118508	hsa-miR-4697-3p	CLIP-seq
MIRT2118509	hsa-miR-4698	CLIP-seq
MIRT2118510	hsa-miR-4701-5p	CLIP-seq
MIRT2118511	hsa-miR-4709-5p	CLIP-seq
MIRT2118512	hsa-miR-513a-3p	CLIP-seq
MIRT1394905	hsa-miR-526b	CLIP-seq
MIRT2118513	hsa-miR-543	CLIP-seq
MIRT2118514	hsa-miR-548v	CLIP-seq
MIRT2118515	hsa-miR-575	CLIP-seq
MIRT2118516	hsa-miR-588	CLIP-seq
MIRT2118517	hsa-miR-590-3p	CLIP-seq
MIRT1394906	hsa-miR-653	CLIP-seq
MIRT2118518	hsa-miR-935	CLIP-seq
MIRT2118494	hsa-miR-197	CLIP-seq
MIRT2118495	hsa-miR-199a-3p	CLIP-seq
MIRT2118496	hsa-miR-199b-3p	CLIP-seq
MIRT2118497	hsa-miR-2277-3p	CLIP-seq
MIRT2118498	hsa-miR-2467-3p	CLIP-seq
MIRT2118499	hsa-miR-3129-5p	CLIP-seq
MIRT2340571	hsa-miR-3614-3p	CLIP-seq
MIRT2118504	hsa-miR-3678-3p	CLIP-seq
MIRT2118505	hsa-miR-3975	CLIP-seq
MIRT2340572	hsa-miR-4312	CLIP-seq
MIRT2118506	hsa-miR-4676-5p	CLIP-seq
MIRT2118507	hsa-miR-4679	CLIP-seq
MIRT2118509	hsa-miR-4698	CLIP-seq
MIRT2118510	hsa-miR-4701-5p	CLIP-seq
MIRT2340573	hsa-miR-494	CLIP-seq
MIRT2340574	hsa-miR-548c-3p	CLIP-seq
MIRT2118514	hsa-miR-548v	CLIP-seq
MIRT2118515	hsa-miR-575	CLIP-seq
MIRT2340575	hsa-miR-587	CLIP-seq
MIRT2118516	hsa-miR-588	CLIP-seq
MIRT2340576	hsa-miR-643	CLIP-seq
MIRT2118518	hsa-miR-935	CLIP-seq
MIRT2118502	hsa-miR-3617	CLIP-seq
MIRT1394902	hsa-miR-4328	CLIP-seq
MIRT2634432	hsa-miR-1184	CLIP-seq
MIRT2634433	hsa-miR-1205	CLIP-seq
MIRT2634434	hsa-miR-1244	CLIP-seq
MIRT2634435	hsa-miR-1279	CLIP-seq
MIRT2634436	hsa-miR-1298	CLIP-seq
MIRT2634437	hsa-miR-144	CLIP-seq
MIRT2634438	hsa-miR-186	CLIP-seq
MIRT2118495	hsa-miR-199a-3p	CLIP-seq
MIRT2118496	hsa-miR-199b-3p	CLIP-seq
MIRT2634439	hsa-miR-205	CLIP-seq
MIRT2634440	hsa-miR-216a	CLIP-seq
MIRT2634441	hsa-miR-223	CLIP-seq
MIRT2118497	hsa-miR-2277-3p	CLIP-seq
MIRT2118498	hsa-miR-2467-3p	CLIP-seq
MIRT2634442	hsa-miR-299-5p	CLIP-seq
MIRT2118499	hsa-miR-3129-5p	CLIP-seq
MIRT2634443	hsa-miR-3133	CLIP-seq
MIRT2118500	hsa-miR-3143	CLIP-seq
MIRT2634444	hsa-miR-3158-5p	CLIP-seq
MIRT2634445	hsa-miR-3166	CLIP-seq
MIRT2634446	hsa-miR-3613-5p	CLIP-seq
MIRT2340571	hsa-miR-3614-3p	CLIP-seq
MIRT2118502	hsa-miR-3617	CLIP-seq
MIRT1394900	hsa-miR-3647-5p	CLIP-seq
MIRT1394901	hsa-miR-3653	CLIP-seq
MIRT2118503	hsa-miR-3658	CLIP-seq
MIRT2634447	hsa-miR-3662	CLIP-seq
MIRT2118504	hsa-miR-3678-3p	CLIP-seq
MIRT2118505	hsa-miR-3975	CLIP-seq
MIRT2634448	hsa-miR-409-3p	CLIP-seq
MIRT2340572	hsa-miR-4312	CLIP-seq
MIRT1394902	hsa-miR-4328	CLIP-seq
MIRT2634449	hsa-miR-4495	CLIP-seq
MIRT2634450	hsa-miR-4496	CLIP-seq
MIRT2634451	hsa-miR-466	CLIP-seq
MIRT2634452	hsa-miR-4672	CLIP-seq
MIRT2118506	hsa-miR-4676-5p	CLIP-seq
MIRT2118508	hsa-miR-4697-3p	CLIP-seq
MIRT2118511	hsa-miR-4709-5p	CLIP-seq
MIRT2634453	hsa-miR-4715-3p	CLIP-seq
MIRT2634454	hsa-miR-4731-3p	CLIP-seq
MIRT2634455	hsa-miR-4771	CLIP-seq
MIRT2634456	hsa-miR-4775	CLIP-seq
MIRT2634457	hsa-miR-4787-3p	CLIP-seq
MIRT2634458	hsa-miR-4801	CLIP-seq
MIRT2634459	hsa-miR-4803	CLIP-seq
MIRT2634460	hsa-miR-487b	CLIP-seq
MIRT2634461	hsa-miR-488	CLIP-seq
MIRT2340573	hsa-miR-494	CLIP-seq
MIRT2118512	hsa-miR-513a-3p	CLIP-seq
MIRT1394905	hsa-miR-526b	CLIP-seq
MIRT2634462	hsa-miR-539	CLIP-seq
MIRT2118513	hsa-miR-543	CLIP-seq
MIRT2634463	hsa-miR-544	CLIP-seq
MIRT2634464	hsa-miR-548ag	CLIP-seq
MIRT2634465	hsa-miR-548ai	CLIP-seq
MIRT2634466	hsa-miR-548m	CLIP-seq
MIRT2118514	hsa-miR-548v	CLIP-seq
MIRT2634467	hsa-miR-562	CLIP-seq
MIRT2118515	hsa-miR-575	CLIP-seq
MIRT2118517	hsa-miR-590-3p	CLIP-seq
MIRT2340576	hsa-miR-643	CLIP-seq
MIRT2634468	hsa-miR-656	CLIP-seq
MIRT2634432	hsa-miR-1184	CLIP-seq
MIRT2634433	hsa-miR-1205	CLIP-seq
MIRT2634434	hsa-miR-1244	CLIP-seq
MIRT2634435	hsa-miR-1279	CLIP-seq
MIRT2634437	hsa-miR-144	CLIP-seq
MIRT2634438	hsa-miR-186	CLIP-seq
MIRT2118495	hsa-miR-199a-3p	CLIP-seq
MIRT2118496	hsa-miR-199b-3p	CLIP-seq
MIRT2634439	hsa-miR-205	CLIP-seq
MIRT2118497	hsa-miR-2277-3p	CLIP-seq
MIRT2118498	hsa-miR-2467-3p	CLIP-seq
MIRT2634442	hsa-miR-299-5p	CLIP-seq
MIRT2118499	hsa-miR-3129-5p	CLIP-seq
MIRT2634443	hsa-miR-3133	CLIP-seq
MIRT2634444	hsa-miR-3158-5p	CLIP-seq
MIRT2692179	hsa-miR-3163	CLIP-seq
MIRT2634445	hsa-miR-3166	CLIP-seq
MIRT2634446	hsa-miR-3613-5p	CLIP-seq
MIRT2340571	hsa-miR-3614-3p	CLIP-seq
MIRT2118502	hsa-miR-3617	CLIP-seq
MIRT1394900	hsa-miR-3647-5p	CLIP-seq
MIRT1394901	hsa-miR-3653	CLIP-seq
MIRT2118503	hsa-miR-3658	CLIP-seq
MIRT2634447	hsa-miR-3662	CLIP-seq
MIRT2118504	hsa-miR-3678-3p	CLIP-seq
MIRT2118505	hsa-miR-3975	CLIP-seq
MIRT2634448	hsa-miR-409-3p	CLIP-seq
MIRT2340572	hsa-miR-4312	CLIP-seq
MIRT1394902	hsa-miR-4328	CLIP-seq
MIRT2634449	hsa-miR-4495	CLIP-seq
MIRT2634450	hsa-miR-4496	CLIP-seq
MIRT2634451	hsa-miR-466	CLIP-seq
MIRT2634452	hsa-miR-4672	CLIP-seq
MIRT2118506	hsa-miR-4676-5p	CLIP-seq
MIRT2692180	hsa-miR-4703-3p	CLIP-seq
MIRT2118511	hsa-miR-4709-5p	CLIP-seq
MIRT2634453	hsa-miR-4715-3p	CLIP-seq
MIRT2634454	hsa-miR-4731-3p	CLIP-seq
MIRT2634455	hsa-miR-4771	CLIP-seq
MIRT2634457	hsa-miR-4787-3p	CLIP-seq
MIRT2634458	hsa-miR-4801	CLIP-seq
MIRT2634459	hsa-miR-4803	CLIP-seq
MIRT2634460	hsa-miR-487b	CLIP-seq
MIRT2634461	hsa-miR-488	CLIP-seq
MIRT2340573	hsa-miR-494	CLIP-seq
MIRT2118512	hsa-miR-513a-3p	CLIP-seq
MIRT1394905	hsa-miR-526b	CLIP-seq
MIRT2634462	hsa-miR-539	CLIP-seq
MIRT2634463	hsa-miR-544	CLIP-seq
MIRT2634464	hsa-miR-548ag	CLIP-seq
MIRT2634465	hsa-miR-548ai	CLIP-seq
MIRT2634466	hsa-miR-548m	CLIP-seq
MIRT2118514	hsa-miR-548v	CLIP-seq
MIRT2634467	hsa-miR-562	CLIP-seq
MIRT2118515	hsa-miR-575	CLIP-seq
MIRT2340576	hsa-miR-643	CLIP-seq
MIRT2634468	hsa-miR-656	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	10383417, 16189514, 16730941, 17078930, 17235283, 19111546, 19278655, 20150893, 24790097, 29892012, 31515488, 32296183, 32814053, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	TAS	8780729
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016236	Process	Macroautophagy	IEA
GO:0016236	Process	Macroautophagy	TAS	20588296
GO:0031901	Component	Early endosome membrane	IEA
GO:0033565	Component	ESCRT-0 complex	IBA
GO:0033565	Component	ESCRT-0 complex	IDA	24790097
GO:0033565	Component	ESCRT-0 complex	IPI	19278655
GO:0033565	Component	ESCRT-0 complex	TAS	20588296
GO:0035091	Function	Phosphatidylinositol binding	IEA
GO:0036258	Process	Multivesicular body assembly	IEA
GO:0036258	Process	Multivesicular body assembly	NAS	19278655
GO:0036258	Process	Multivesicular body assembly	TAS	20588296
GO:0043130	Function	Ubiquitin binding	IEA
GO:0043328	Process	Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA
GO:0043328	Process	Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	NAS	19278655
GO:0044389	Function	Ubiquitin-like protein ligase binding	IPI	24790097
GO:0090148	Process	Membrane fission	NAS	19278655
GO:1903543	Process	Positive regulation of exosomal secretion	IMP	24105262
GO:1903551	Process	Regulation of extracellular exosome assembly	IMP	24105262

MIM	HGNC	e!Ensembl
601899	11357	ENSG00000136738

Q92783

Protein name

Signal transducing adapter molecule 1 (STAM-1)

Protein function

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involv

PDB

2L0A , 3F1I , 3LDZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00790	VHS	5 → 139	VHS domain	Domain
PF02809	UIM	171 → 187	Ubiquitin interaction motif	Motif
PF00018	SH3_1	216 → 261	SH3 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:8780729}.

Sequence

MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPH
VAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFK
NDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAI
ELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVL
DDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQFSDDVQVETIEPEPEPA
FIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSEL
NVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQVYAGPPPSGAYLVAGNA
QMSHLQSYSLPPEQLSSLSQAVVPPSANPALPSQQTQAAYPNTMVSSVQGNTYPSQAPVY
SPPPAATAAAATADVTLYQNAGPNMPQVPNYNLTSSTLPQPGGSQQPPQPQQPYSQKALL

Sequence length

540

Interactions

View interactions

	KEGG		Reactome
	Endocytosis JAK-STAT signaling pathway		EGFR downregulation Metalloprotease DUBs Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Endosomal Sorting Complex Required For Transport (ESCRT)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Autism Spectrum Disorder	Associate	28281572	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	38049741	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ependymoma	Associate	14578171	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Associate	32065482	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	14578171	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Associate	27581326	★★★★★ ★☆☆☆☆ Found in Text Mining only

STAM (signal transducing adaptor molecule)