TASL (TLR adaptor interacting with endolysosomal SLC15A4)

Gene
Gene Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
80231
Gene name Gene Name - the full gene name approved by the HGNC.
TLR adaptor interacting with endolysosomal SLC15A4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TASL
Synonyms (NCBI Gene) Gene synonyms aliases
CXorf21
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xp21.2
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32433612
GO:0005634 Component Nucleus IEA
GO:0034157 Process Positive regulation of toll-like receptor 7 signaling pathway IMP 32433612
GO:0034161 Process Positive regulation of toll-like receptor 8 signaling pathway IMP 32433612
GO:0035751 Process Regulation of lysosomal lumen pH IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
301049 25667 ENSG00000120280
Protein
Gene Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9HAI6
Protein name TLR adapter interacting with SLC15A4 on the lysosome
Protein function Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:32433612). Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9,
PDB 8JZU , 8WX5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15133 DUF4569 1 → 296 Domain of unknown function (DUF4569) Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in immune cell types such as B-cells, neutrophils, dendritic cells and monocytes, the expression levels are two-three-fold higher in female cells compared to male cells (at protein level) (PubMed:31001245, PubMed:31092
Sequence
Sequence length 301
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Systemic lupus erythematosus Systemic lupus erythematosus GWAS