Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
80196
Gene name Gene Name - the full gene name approved by the HGNC.
Ring finger protein 34
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RNF34
Synonyms (NCBI Gene) Gene synonyms aliases
CARP-1, CARP1, RFI, RIF, RIFF, hRFI
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.31
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Ove
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025100 hsa-miR-181a-5p Sequencing 20371350
MIRT028023 hsa-miR-93-5p Sequencing 20371350
MIRT047982 hsa-miR-30c-5p CLASH 23622248
MIRT046149 hsa-miR-30b-5p CLASH 23622248
MIRT693371 hsa-miR-106a-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002039 Function P53 binding IPI 17121812, 18382127
GO:0005515 Function Protein binding IPI 15069192, 22064484, 25416956, 32814053
GO:0005634 Component Nucleus IDA 22064484
GO:0005654 Component Nucleoplasm IDA
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608299 17297 ENSG00000170633
Protein
UniProt ID Q969K3
Protein name E3 ubiquitin-protein ligase RNF34 (EC 2.3.2.27) (Caspase regulator CARP1) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (RING finger p
Protein function E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to n
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13920 zf-C3HC4_3 321 366 Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269|PubMed:12118383, ECO:0000269|PubMed:15069192}.
Sequence
MKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPNI
VCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLKV
KDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSFF
SNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENAE
DRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRLY
KENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICR
QYVVRA
VHVFKS
Sequence length 372
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Regulation of TP53 Degradation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 16270526
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 12816952
Colorectal Neoplasms Associate 16080519, 29182684
Medulloblastoma Associate 23826121
Mesothelioma Associate 19960346
Neoplasms Inhibit 25033461
Neuroblastoma Associate 25033461