Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8019
Gene name Gene Name - the full gene name approved by the HGNC.
Bromodomain containing 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BRD3
Synonyms (NCBI Gene) Gene synonyms aliases
FSHRG2, ORFX, RING3L
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003279 hsa-miR-141-3p Luciferase reporter assay, Western blot 20053927
MIRT003279 hsa-miR-141-3p Luciferase reporter assay, Western blot 20053927
MIRT004162 hsa-miR-192-5p Microarray 16822819
MIRT003279 hsa-miR-141-3p Reporter assay;Western blot;Other 20053927
MIRT029195 hsa-miR-26b-5p Microarray 19088304
Transcription factors
Transcription factor Regulation Reference
BRD7 Activation 12600283
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003682 Function Chromatin binding IDA 18406326
GO:0005515 Function Protein binding IPI 20195357
GO:0005634 Component Nucleus IEA
GO:0006325 Process Chromatin organization IEA
GO:0006357 Process Regulation of transcription by RNA polymerase II IDA 18406326
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601541 1104 ENSG00000169925
Protein
UniProt ID Q15059
Protein name Bromodomain-containing protein 3 (RING3-like protein)
Protein function Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coac
PDB 2E7N , 2NXB , 2OO1 , 2YW5 , 3S91 , 3S92 , 5A7C , 5HFR , 5HJC , 6BGG , 6BGH , 6I41 , 6I5P , 6I68 , 6I7A , 6QJU , 6U4A , 6ULP , 7JMY , 7JQ8 , 7JYN , 7JYZ , 7L72 , 7L9L , 7LAY , 7LAZ , 7LB4 , 7LBT , 7R8R , 7RJK , 7RJL , 7RJM , 7RJN , 7S3P , 7TO7 , 7TO8 , 7TO9 , 7TOA , 7UG5 , 8B5A , 8CV5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00439 Bromodomain 42 128 Bromodomain Domain
PF00439 Bromodomain 315 403 Bromodomain Domain
PF17035 BET 571 635 Bromodomain extra-terminal - transcription regulation Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9373153}.
Sequence
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQA
LEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARK
LQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKS
CLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
Sequence length 726
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Gastric Adenocarcinoma rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
Medulloblastoma Medulloblastoma, Childhood Medulloblastoma, Adult Medulloblastoma, Desmoplastic Medulloblastoma, Melanotic medulloblastoma rs1589970134, rs587776578, rs587776579, rs17847577, rs111033171, rs80359604, rs80358785, rs80358814, rs863224925, rs1555950011, rs1554231278, rs926177767, rs759412460, rs1564032829, rs761911009 24231268
Renal carcinoma Conventional (Clear Cell) Renal Cell Carcinoma rs121913668, rs121913670, rs121913243, rs786202724
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
31374203
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Adrenocortical Carcinoma Associate 36793283
Breast Neoplasms Associate 25001387, 31551256, 34813359
Carcinoma Non Small Cell Lung Associate 34605158
Carcinoma Pancreatic Ductal Associate 34313325
Carcinoma Squamous Cell Associate 24875858
Developmental Disabilities Associate 35468861
Hemangiosarcoma Associate 33016928
Inflammation Associate 31300040
Leiomyosarcoma Stimulate 39273015
Leukemia Associate 25989842