Gene Gene information from NCBI Gene database.
Entrez ID 8019
Gene name Bromodomain containing 3
Gene symbol BRD3
Synonyms (NCBI Gene)
FSHRG2ORFXRING3L
Chromosome 9
Chromosome location 9q34.2
Summary This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein
miRNA miRNA information provided by mirtarbase database.
1081
miRTarBase ID miRNA Experiments Reference
MIRT003279 hsa-miR-141-3p Luciferase reporter assayWestern blot 20053927
MIRT003279 hsa-miR-141-3p Luciferase reporter assayWestern blot 20053927
MIRT004162 hsa-miR-192-5p Microarray 16822819
MIRT003279 hsa-miR-141-3p Reporter assay;Western blot;Other 20053927
MIRT029195 hsa-miR-26b-5p Microarray 19088304
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
BRD7 Activation 12600283
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IBA
GO:0000785 Component Chromatin IDA 32895492
GO:0003682 Function Chromatin binding IBA
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0005515 Function Protein binding IPI 20195357, 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601541 1104 ENSG00000169925
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15059
Protein name Bromodomain-containing protein 3 (RING3-like protein)
Protein function Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coac
PDB 2E7N , 2NXB , 2OO1 , 2YW5 , 3S91 , 3S92 , 5A7C , 5HFR , 5HJC , 6BGG , 6BGH , 6I41 , 6I5P , 6I68 , 6I7A , 6QJU , 6U4A , 6ULP , 7JMY , 7JQ8 , 7JYN , 7JYZ , 7L72 , 7L9L , 7LAY , 7LAZ , 7LB4 , 7LBT , 7R8R , 7RJK , 7RJL , 7RJM , 7RJN , 7S3P , 7TO7 , 7TO8 , 7TO9 , 7TOA , 7UG5 , 8B5A , 8CV5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00439 Bromodomain 42 128 Bromodomain Domain
PF00439 Bromodomain 315 403 Bromodomain Domain
PF17035 BET 571 635 Bromodomain extra-terminal - transcription regulation Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9373153}.
Sequence
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQA
LEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARK
LQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKS
CLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
Sequence length 726
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Premature ovarian failure Uncertain significance rs1830145204 RCV001270216
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adrenocortical Carcinoma Associate 36793283
Breast Neoplasms Associate 25001387, 31551256, 34813359
Carcinoma Non Small Cell Lung Associate 34605158
Carcinoma Pancreatic Ductal Associate 34313325
Carcinoma Squamous Cell Associate 24875858
Developmental Disabilities Associate 35468861
Hemangiosarcoma Associate 33016928
Inflammation Associate 31300040
Leiomyosarcoma Stimulate 39273015
Leukemia Associate 25989842