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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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8019
|
|
Gene name
Gene Name - the full gene name approved by the HGNC.
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Bromodomain containing 3 |
|
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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BRD3 |
|
Synonyms (NCBI Gene)
Gene synonyms aliases
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FSHRG2, ORFX, RING3L |
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Chromosome
Chromosome number
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9 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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9q34.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein |
| UniProt ID |
Q15059
|
| Protein name |
Bromodomain-containing protein 3 (RING3-like protein) |
| Protein function |
Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coac |
| PDB |
2E7N
,
2NXB
,
2OO1
,
2YW5
,
3S91
,
3S92
,
5A7C
,
5HFR
,
5HJC
,
6BGG
,
6BGH
,
6I41
,
6I5P
,
6I68
,
6I7A
,
6QJU
,
6U4A
,
6ULP
,
7JMY
,
7JQ8
,
7JYN
,
7JYZ
,
7L72
,
7L9L
,
7LAY
,
7LAZ
,
7LB4
,
7LBT
,
7R8R
,
7RJK
,
7RJL
,
7RJM
,
7RJN
,
7S3P
,
7TO7
,
7TO8
,
7TO9
,
7TOA
,
7UG5
,
8B5A
,
8CV5
|
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
|
PF00439
|
Bromodomain |
42 → 128 |
Bromodomain |
Domain |
|
PF00439
|
Bromodomain |
315 → 403 |
Bromodomain |
Domain |
|
PF17035
|
BET |
571 → 635 |
Bromodomain extra-terminal - transcription regulation |
Domain |
|
| Tissue specificity |
TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9373153}. |
| Sequence |
|
| Sequence length |
726 |
| Interactions |
View interactions
|
|
Unknown
Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
|
| Disease merge term |
Disease name |
Evidence |
References |
Source |
| Colorectal Cancer |
Colorectal cancer |
N/A |
N/A |
GWAS |
| Diabetes |
Type 2 diabetes, Type 2 diabetes (PheCode 250.2) |
N/A |
N/A |
GWAS |
|
|
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