Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8019
Gene name Gene Name - the full gene name approved by the HGNC.
Bromodomain containing 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BRD3
Synonyms (NCBI Gene) Gene synonyms aliases
FSHRG2, ORFX, RING3L
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003279 hsa-miR-141-3p Luciferase reporter assay, Western blot 20053927
MIRT003279 hsa-miR-141-3p Luciferase reporter assay, Western blot 20053927
MIRT004162 hsa-miR-192-5p Microarray 16822819
MIRT003279 hsa-miR-141-3p Reporter assay;Western blot;Other 20053927
MIRT029195 hsa-miR-26b-5p Microarray 19088304
Transcription factors
Transcription factor Regulation Reference
BRD7 Activation 12600283
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IBA
GO:0000785 Component Chromatin IDA 32895492
GO:0003682 Function Chromatin binding IBA
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0005515 Function Protein binding IPI 20195357, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601541 1104 ENSG00000169925
Protein
UniProt ID Q15059
Protein name Bromodomain-containing protein 3 (RING3-like protein)
Protein function Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coac
PDB 2E7N , 2NXB , 2OO1 , 2YW5 , 3S91 , 3S92 , 5A7C , 5HFR , 5HJC , 6BGG , 6BGH , 6I41 , 6I5P , 6I68 , 6I7A , 6QJU , 6U4A , 6ULP , 7JMY , 7JQ8 , 7JYN , 7JYZ , 7L72 , 7L9L , 7LAY , 7LAZ , 7LB4 , 7LBT , 7R8R , 7RJK , 7RJL , 7RJM , 7RJN , 7S3P , 7TO7 , 7TO8 , 7TO9 , 7TOA , 7UG5 , 8B5A , 8CV5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00439 Bromodomain 42 128 Bromodomain Domain
PF00439 Bromodomain 315 403 Bromodomain Domain
PF17035 BET 571 635 Bromodomain extra-terminal - transcription regulation Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9373153}.
Sequence
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQA
LEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARK
LQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKS
CLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
Sequence length 726
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Colorectal Cancer Colorectal cancer N/A N/A GWAS
Diabetes Type 2 diabetes, Type 2 diabetes (PheCode 250.2) N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adrenocortical Carcinoma Associate 36793283
Breast Neoplasms Associate 25001387, 31551256, 34813359
Carcinoma Non Small Cell Lung Associate 34605158
Carcinoma Pancreatic Ductal Associate 34313325
Carcinoma Squamous Cell Associate 24875858
Developmental Disabilities Associate 35468861
Hemangiosarcoma Associate 33016928
Inflammation Associate 31300040
Leiomyosarcoma Stimulate 39273015
Leukemia Associate 25989842