Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	80059
Gene name Gene Name - the full gene name approved by the HGNC.	Leucine rich repeat transmembrane neuronal 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LRRTM4
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p12

Show/Hide all(46)

miRTarBase ID	miRNA	Experiments	Reference
MIRT527180	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT527179	hsa-miR-1297	PAR-CLIP	22012620
MIRT527178	hsa-miR-26a-5p	PAR-CLIP	22012620
MIRT527177	hsa-miR-26b-5p	PAR-CLIP	22012620
MIRT527176	hsa-miR-4465	PAR-CLIP	22012620
MIRT527175	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT527173	hsa-miR-1305	PAR-CLIP	22012620
MIRT527179	hsa-miR-1297	PAR-CLIP	27292025
MIRT527173	hsa-miR-1305	PAR-CLIP	27292025
MIRT527180	hsa-miR-205-5p	PAR-CLIP	27292025
MIRT527178	hsa-miR-26a-5p	PAR-CLIP	27292025
MIRT527177	hsa-miR-26b-5p	PAR-CLIP	27292025
MIRT527176	hsa-miR-4465	PAR-CLIP	27292025
MIRT527175	hsa-miR-6868-3p	PAR-CLIP	27292025
MIRT527180	hsa-miR-205-5p	PAR-CLIP	22012620
MIRT527179	hsa-miR-1297	PAR-CLIP	22012620
MIRT527178	hsa-miR-26a-5p	PAR-CLIP	22012620
MIRT527177	hsa-miR-26b-5p	PAR-CLIP	22012620
MIRT527176	hsa-miR-4465	PAR-CLIP	22012620
MIRT527175	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT527173	hsa-miR-1305	PAR-CLIP	22012620
MIRT1121109	hsa-miR-1470	CLIP-seq
MIRT1121110	hsa-miR-3614-3p	CLIP-seq
MIRT1121111	hsa-miR-3651	CLIP-seq
MIRT1121112	hsa-miR-4290	CLIP-seq
MIRT1121113	hsa-miR-4469	CLIP-seq
MIRT1121114	hsa-miR-4493	CLIP-seq
MIRT1121115	hsa-miR-4540	CLIP-seq
MIRT1121116	hsa-miR-4667-3p	CLIP-seq
MIRT1121117	hsa-miR-1245	CLIP-seq
MIRT1121118	hsa-miR-1324	CLIP-seq
MIRT1121119	hsa-miR-3133	CLIP-seq
MIRT1121120	hsa-miR-338-3p	CLIP-seq
MIRT1121121	hsa-miR-3591-3p	CLIP-seq
MIRT1121122	hsa-miR-4530	CLIP-seq
MIRT1121123	hsa-miR-4668-3p	CLIP-seq
MIRT1121124	hsa-miR-4765	CLIP-seq
MIRT1121125	hsa-miR-548b-3p	CLIP-seq
MIRT2453428	hsa-miR-1273g	CLIP-seq
MIRT2453429	hsa-miR-331-3p	CLIP-seq
MIRT2453430	hsa-miR-3925-3p	CLIP-seq
MIRT2453431	hsa-miR-4690-3p	CLIP-seq
MIRT2453432	hsa-miR-515-5p	CLIP-seq
MIRT2453433	hsa-miR-766	CLIP-seq
MIRT1121119	hsa-miR-3133	CLIP-seq
MIRT2563604	hsa-miR-323-3p	CLIP-seq

Show/Hide all(7)

GO ID	Ontology	Definition	Evidence
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IBA

MIM	HGNC	e!Ensembl
610870	19411	ENSG00000176204

Protein

UniProt ID

Q86VH4

Protein name

Leucine-rich repeat transmembrane neuronal protein 4

Protein function

May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	64 → 121	Leucine rich repeat	Repeat
PF13855	LRR_8	109 → 169	Leucine rich repeat	Repeat
PF13855	LRR_8	157 → 217	Leucine rich repeat	Repeat
PF13855	LRR_8	229 → 289	Leucine rich repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in neuronal tissues. {ECO:0000269|PubMed:12676565}.

Sequence

MGFHLITQLKGMSVVLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENIS
GGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNK
ITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDC
RNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNR
IRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAW
ISLISITLSGNMWECSRSICPLFYWLKNFKGNKESTMICAGPKHIQGEKVSDAVETYNIC
SEVQVVNTERSHLVPQTPQKPLIIPRPTIFKPDVTQSTFETPSPSPGFQIPGAEQEYEHV
SFHKIIAGSVALFLSVAMILLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSP
LQEYYVDYKPTNSETMDISVNGSGPCTYTISGSRECEMPHHMKPLPYYSYDQPVIGYCQA
HQPLHVTKGYETVSPEQDESPGLELGRDHSFIATIARSAAPAIYLERIAN

Sequence length

590

Interactions

View interactions

	Reactome
			Neurexins and neuroligins

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast Cancer	Breast cancer specific mortality in estrogen receptor negative breast cancer	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS
Restless Legs Syndrome	Restless legs syndrome	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Anxiety	Associate	34684344
Attention Deficit Disorder with Hyperactivity	Associate	35052406
Autism Spectrum Disorder	Associate	35052406
Autistic Disorder	Associate	35052406
Bipolar Disorder	Associate	31854516
Cerebrovascular Disorders	Associate	35994481
Depressive Disorder	Associate	34684344
Tourette Syndrome	Associate	35052406

LRRTM4 (leucine rich repeat transmembrane neuronal 4)