PSCA (prostate stem cell antigen)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8000
Gene name Gene Name - the full gene name approved by the HGNC.
Prostate stem cell antigen
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PSCA
Synonyms (NCBI Gene) Gene synonyms aliases
PRO232, lncPSCA
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q24.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large pro
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(18)
miRTarBase ID miRNA Experiments Reference
MIRT2305411 hsa-miR-1258 CLIP-seq
MIRT2305412 hsa-miR-1265 CLIP-seq
MIRT2305413 hsa-miR-2392 CLIP-seq
MIRT2305414 hsa-miR-3166 CLIP-seq
MIRT2305415 hsa-miR-4494 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
AR Unknown 23330817
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0005576 Component Extracellular region TAS
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane IDA
GO:0005886 Component Plasma membrane TAS
GO:0031225 Component Anchored component of membrane IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
602470 9500 ENSG00000167653
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O43653
Protein name Prostate stem cell antigen
Protein function May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. ; May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inh
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00021 UPAR_LY6 14 → 84 u-PAR/Ly-6 domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (col
Sequence
Sequence length 114
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Post-translational modification: synthesis of GPI-anchored proteins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Gastric Adenocarcinoma, Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)		 26098866, 18488030
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 16015594
Show/Hide Unknown Diseases (3)
Unknown
Disease term Disease name Evidence References Source
Nasopharyngeal carcinoma Nasopharyngeal carcinoma These data suggest that KAT7 can contribute NPC cell growth and survival through up-regulation of NPC-essential genes. 20512145 ClinVar, CBGDA
Duodenal Ulcer Duodenal Ulcer GWAS
Gastric ulcer Gastric ulcer GWAS
Show/Hide Text Mining Associations (36)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 21070776, 23984394
Breast Neoplasms Associate 22502712, 27050280
Carcinogenesis Associate 23984394, 24654646, 24719866, 25374226, 33213418, 40302098
Carcinoma Acinar Cell Associate 19822092
Carcinoma Pancreatic Ductal Associate 22646265
Carcinoma Transitional Cell Associate 20082273
Colorectal Neoplasms Associate 26320491
COVID 19 Associate 33098359
Diabetes Mellitus Type 2 Associate 22536212
Diabetic Nephropathies Associate 22536212