DOK3 (docking protein 3)

Gene

• Entrez ID: 79930
• Gene name: Docking protein 3
• Gene symbol: DOK3
• Synonyms (NCBI Gene): DOKL
• Chromosome: 5
• Chromosome location: 5q35.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044507	hsa-miR-320a	CLASH	23622248
MIRT044507	hsa-miR-320a	CLASH	23622248
MIRT943095	hsa-miR-3202	CLIP-seq
MIRT943096	hsa-miR-3925-5p	CLIP-seq
MIRT943097	hsa-miR-4271	CLIP-seq
MIRT943098	hsa-miR-4475	CLIP-seq
MIRT943099	hsa-miR-4716-3p	CLIP-seq
MIRT943100	hsa-miR-4725-3p	CLIP-seq
MIRT943101	hsa-miR-4747-5p	CLIP-seq
MIRT943102	hsa-miR-4773	CLIP-seq
MIRT943103	hsa-miR-625	CLIP-seq
MIRT943104	hsa-miR-3134	CLIP-seq
MIRT943105	hsa-miR-3185	CLIP-seq
MIRT943106	hsa-miR-4476	CLIP-seq
MIRT943107	hsa-miR-3130-3p	CLIP-seq
MIRT943108	hsa-miR-433	CLIP-seq
MIRT943109	hsa-miR-4677-3p	CLIP-seq
MIRT943110	hsa-miR-4679	CLIP-seq
MIRT943111	hsa-miR-4793-3p	CLIP-seq
MIRT943112	hsa-miR-627	CLIP-seq
MIRT943113	hsa-miR-664	CLIP-seq
MIRT943114	hsa-miR-924	CLIP-seq
MIRT1979249	hsa-miR-3144-5p	CLIP-seq
MIRT1979250	hsa-miR-3191	CLIP-seq
MIRT1979251	hsa-miR-4652-5p	CLIP-seq
MIRT2214402	hsa-miR-3194-3p	CLIP-seq
MIRT2214403	hsa-miR-3921	CLIP-seq
MIRT2214404	hsa-miR-4303	CLIP-seq
MIRT2214405	hsa-miR-4653-5p	CLIP-seq
MIRT943109	hsa-miR-4677-3p	CLIP-seq
MIRT943110	hsa-miR-4679	CLIP-seq
MIRT2214406	hsa-miR-4795-3p	CLIP-seq
MIRT2387072	hsa-miR-1183	CLIP-seq
MIRT2387073	hsa-miR-3125	CLIP-seq
MIRT943105	hsa-miR-3185	CLIP-seq
MIRT2387074	hsa-miR-3916	CLIP-seq
MIRT2387075	hsa-miR-3919	CLIP-seq
MIRT2387076	hsa-miR-3928	CLIP-seq
MIRT2387077	hsa-miR-4257	CLIP-seq
MIRT943106	hsa-miR-4476	CLIP-seq
MIRT2387078	hsa-miR-4709-3p	CLIP-seq
MIRT2448475	hsa-miR-1294	CLIP-seq
MIRT2448476	hsa-miR-2355-5p	CLIP-seq
MIRT2448477	hsa-miR-3679-3p	CLIP-seq
MIRT2448478	hsa-miR-4316	CLIP-seq
MIRT2448479	hsa-miR-4633-5p	CLIP-seq
MIRT943109	hsa-miR-4677-3p	CLIP-seq
MIRT2448480	hsa-miR-532-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17290227, 25416956, 31515488
GO:0005886	Component	Plasma membrane	TAS
GO:0030667	Component	Secretory granule membrane	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS

Other IDs

• MIM: 611435
• HGNC: 24583
• e!Ensembl: ENSG00000146094

Protein

• UniProt ID: Q7L591
• Protein name: Docking protein 3 (Downstream of tyrosine kinase 3)
• Protein function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02174	IRS	213 → 312	PTB domain (IRS-1 type)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in spleen. {ECO:0000269|PubMed:12595900}.
• Sequence:

  MTRGARLRSDARAQLNQLSLDGGTGSGQKGKCEEFPSSLSSVSPGLEAAALLLAVTMDPL
  ETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPG
  RRGERRVIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAQHRQAWMGPICQLAFP
  GTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVL
  GPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAFSTPCAPDLC
  RAVAGAIARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPTSRKMHLAEP
  GPQSLPLLLGPEPNDLASGLYASVCKRASGPPGNEHLYENLCVLEASPTLHGGEPEPHEG
  PGSRSPTTSPIYHNGQDLSWPGPANDSTLEAQYRRLLELDQVEGTGRPDPQAGFKAKLVT
  LLSRERRKGPAPCDRP

• Sequence length: 496

Pathways

Reactome:

Neutrophil degranulation

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537	29212778
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	20139980

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Renal Cell	Associate	34872567, 37235715
Colorectal Neoplasms	Associate	20970032
Lung Neoplasms	Associate	36028467
Lymphatic Metastasis	Associate	37235715
Neoplasm Metastasis	Associate	37235715
Neoplasms	Associate	35127166, 36210538, 37235715
Pneumocystis Infections	Associate	36210538
Squamous Cell Carcinoma of Head and Neck	Associate	36210538