Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7984
Gene name Gene Name - the full gene name approved by the HGNC.	Rho guanine nucleotide exchange factor 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ARHGEF5
Synonyms (NCBI Gene) Gene synonyms aliases	GEF5, P60, TIM, TIM1
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q35
Summary Summary of gene provided in NCBI Entrez Gene.	Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein m

Show/Hide all(69)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030322	hsa-miR-26b-5p	Microarray	19088304
MIRT052259	hsa-let-7b-5p	CLASH	23622248
MIRT047144	hsa-miR-183-5p	CLASH	23622248
MIRT630133	hsa-miR-5693	HITS-CLIP	23824327
MIRT630132	hsa-miR-1267	HITS-CLIP	23824327
MIRT630131	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT630130	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT630129	hsa-miR-3135b	HITS-CLIP	23824327
MIRT630128	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT630127	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT630126	hsa-miR-3652	HITS-CLIP	23824327
MIRT630125	hsa-miR-4430	HITS-CLIP	23824327
MIRT630124	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT630123	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT630122	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT630121	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT630120	hsa-miR-8057	HITS-CLIP	23824327
MIRT630119	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT630118	hsa-miR-5698	HITS-CLIP	23824327
MIRT630133	hsa-miR-5693	HITS-CLIP	23824327
MIRT630132	hsa-miR-1267	HITS-CLIP	23824327
MIRT630131	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT630130	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT630129	hsa-miR-3135b	HITS-CLIP	23824327
MIRT630128	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT630127	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT630126	hsa-miR-3652	HITS-CLIP	23824327
MIRT630125	hsa-miR-4430	HITS-CLIP	23824327
MIRT630124	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT630123	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT630122	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT630121	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT630120	hsa-miR-8057	HITS-CLIP	23824327
MIRT630119	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT630118	hsa-miR-5698	HITS-CLIP	23824327
MIRT795979	hsa-miR-3200-3p	CLIP-seq
MIRT795980	hsa-miR-330-3p	CLIP-seq
MIRT795981	hsa-miR-3919	CLIP-seq
MIRT795982	hsa-miR-4330	CLIP-seq
MIRT795983	hsa-miR-4756-3p	CLIP-seq
MIRT795984	hsa-miR-603	CLIP-seq
MIRT1935096	hsa-miR-1470	CLIP-seq
MIRT1935097	hsa-miR-4287	CLIP-seq
MIRT1935098	hsa-miR-4469	CLIP-seq
MIRT1935099	hsa-miR-4667-3p	CLIP-seq
MIRT1935100	hsa-miR-4685-3p	CLIP-seq
MIRT1935101	hsa-miR-4768-3p	CLIP-seq
MIRT1935102	hsa-miR-665	CLIP-seq
MIRT2175032	hsa-miR-23a	CLIP-seq
MIRT2175033	hsa-miR-23b	CLIP-seq
MIRT2175034	hsa-miR-23c	CLIP-seq
MIRT2175035	hsa-miR-3064-3p	CLIP-seq
MIRT795979	hsa-miR-3200-3p	CLIP-seq
MIRT2175036	hsa-miR-3620	CLIP-seq
MIRT2175037	hsa-miR-376c	CLIP-seq
MIRT795981	hsa-miR-3919	CLIP-seq
MIRT2175038	hsa-miR-4317	CLIP-seq
MIRT795982	hsa-miR-4330	CLIP-seq
MIRT2175039	hsa-miR-4502	CLIP-seq
MIRT2175040	hsa-miR-4656	CLIP-seq
MIRT2175041	hsa-miR-4695-3p	CLIP-seq
MIRT2175042	hsa-miR-4715-3p	CLIP-seq
MIRT2175043	hsa-miR-4725-5p	CLIP-seq
MIRT795983	hsa-miR-4756-3p	CLIP-seq
MIRT2175044	hsa-miR-504	CLIP-seq
MIRT795984	hsa-miR-603	CLIP-seq
MIRT2175045	hsa-miR-767-5p	CLIP-seq
MIRT2175046	hsa-miR-877	CLIP-seq
MIRT2175047	hsa-miR-944	CLIP-seq

Show/Hide all(36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002102	Component	Podosome	IEA
GO:0002408	Process	Myeloid dendritic cell chemotaxis	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	15601624
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005515	Function	Protein binding	IPI	12006984, 15778465, 21988832, 24189400, 25416956, 25911094, 27107012, 31980649, 32203420, 32296183, 33961781, 34591642, 36931259
GO:0005525	Function	GTP binding	TAS	8134109
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	14662653
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	14662653
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0008289	Function	Lipid binding	IEA
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IBA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IEA
GO:0032956	Process	Regulation of actin cytoskeleton organization	IMP	14662653
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043087	Process	Regulation of GTPase activity	IDA	21525037
GO:0043507	Process	Positive regulation of JUN kinase activity	IDA	15601624
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051091	Process	Positive regulation of DNA-binding transcription factor activity	IDA	15601624
GO:0051493	Process	Regulation of cytoskeleton organization	IMP	15601624
GO:0051496	Process	Positive regulation of stress fiber assembly	IMP	15601624
GO:0061484	Process	Hematopoietic stem cell homeostasis	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IDA	15601624
GO:0071803	Process	Positive regulation of podosome assembly	IEA
GO:0071944	Component	Cell periphery	IDA	25911094
GO:1904591	Process	Positive regulation of protein import	IMP	15601624

MIM	HGNC	e!Ensembl
600888	13209	ENSG00000050327

Protein

UniProt ID

Q12774

Protein name

Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)

Protein function

Guanine nucleotide exchange factor which activates Rho GTPases (PubMed:15601624). Strongly activates RHOA (PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similar

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15441	ARHGEF5_35	1 → 478	RhoGEF 5/35 N-terminal disordered region	Disordered
PF00621	RhoGEF	1178 → 1356	RhoGEF domain	Domain
PF14604	SH3_9	1518 → 1567	Variant SH3 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed with highest levels in placenta. High levels are also found in colon, kidney, trachea, prostate, liver, pancreas, pituitary gland, thyroid gland and mammary gland. In fetal tissues, expressed at high levels in ki

Sequence

MEAEEAQRGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQ
QSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGRQARTLA
PPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQT
RYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGF
RGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGL
NDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQE
DHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCD
LFPGASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEID
QNSQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVA
FPRRETSCAARAPETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQ
HLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVS
ASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVR
IHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQAS
DPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLP
PLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPP
ATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHP
EAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSG
QAVAPSEGANKHKGWSRQGLRRPSILPEGSSDSRGPAVEKHPGPSDTVVFREKKPKEVMG
GFSRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESY
LQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHF
QLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDF
RRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRL
KLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECK
IFPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVF
DHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMP
REELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGW
FPVQQVEFISNPEVRAQNLKEAHRVKTAKLQLVEQQA

Sequence length

1597

Interactions

View interactions

	Reactome
			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast cancer	Breast cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (21)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Asthma	Associate	20415862
Carcinoma in Situ	Associate	28374866
Cardiomyopathy Dilated	Associate	27818477
Communication Disorders	Associate	31800133
Encephalitis Japanese	Associate	30441759
Gastroesophageal Reflux	Associate	26337663
Heart Failure	Associate	38573265
Hernia	Associate	23631828
Ige Responsiveness Atopic	Associate	20415862
Immune System Diseases	Associate	27818477
Infections	Associate	30441759
Inflammation	Associate	31800133
Laryngeal Neoplasms	Associate	28374866
Leukemia Myeloid Acute	Associate	38003617
Melanoma	Associate	20178651
Melanoma Cutaneous Malignant	Associate	20178651
Mycosis Fungoides	Associate	33098490
Neoplasm Metastasis	Associate	20178651
Neoplasms	Associate	20178651, 22081375, 23109837, 23497351, 28374866, 38003617
Non Muscle Invasive Bladder Neoplasms	Associate	32096345
Sick Sinus Syndrome	Associate	20178651

ARHGEF5 (Rho guanine nucleotide exchange factor 5)