Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
79699
Gene name Gene Name - the full gene name approved by the HGNC.
Zyg-11 family member B, cell cycle regulator
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZYG11B
Synonyms (NCBI Gene) Gene synonyms aliases
ZYG11
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p32.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT031006 hsa-miR-21-5p Microarray 18591254
MIRT611671 hsa-miR-548ae-3p HITS-CLIP 23824327
MIRT611670 hsa-miR-548ah-3p HITS-CLIP 23824327
MIRT611669 hsa-miR-548aj-3p HITS-CLIP 23824327
MIRT611668 hsa-miR-548am-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 17304241, 21145461, 32296183, 32814053
GO:0006515 Process Protein quality control for misfolded or incompletely synthesized proteins IMP 31273098
GO:0031462 Component Cul2-RING ubiquitin ligase complex IBA 21873635
GO:0031462 Component Cul2-RING ubiquitin ligase complex IDA 31273098
GO:0032436 Process Positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 31273098
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
618673 25820 ENSG00000162378
Protein
UniProt ID Q9C0D3
Protein name Protein zyg-11 homolog B
Protein function Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts to target substrates bearing N-terminal degrons for proteasomal degradation with the first four residues of substrates being the key recognition
PDB 7EP0 , 7EP1 , 7EP2 , 7XV7 , 7XYV , 7XYW , 7XYX , 7YC2
Family and domains
Sequence
MPEDQAGAAMEEASPYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLR
TMAFHGLLNDGTVGIFRGNQMRLKRACIRKAKISAVAFRKAFCHHKLVELDATGVNADIT
ITDIISGLGSNKWIQQNLQCLVLNSLTLSLEDPYERCFSRLSGLRALSITNVLFYNEDLA
EVASLPRLESLDISNTSITDITALLACKDRLKSLTMHHLKCLKMTTTQILDVVRELKHLN
HLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTDKAVEAFIQQRPSMQFVGLL
ATDAGYSEFLTGEGHLKVSGEANETQIAEALKRYSERAFFVREALFHLFSLTHVMEKTKP
EILKLVVTGMRNHPMNLPVQLAASACVFNLTKQDLAAGMPVRLLADVTHLLLKAMEHFPN
HQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHEDQNMQRMAVAIISILAAKLS
TEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLTDESPTTCRHFIENQG
LELFMRVLESFPTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSLLHSVEVEVSY
FAAGIIAHLISRGEQAWTLSRSQRNSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGC
FTTPGVQLWAVWAMQHVCSKNPSRYCSMLIEEGGLQHLYNIKDHEHTDPHVQQIAVAILD
SLEKHIVRHGRPPPCKKQPQARLN
Sequence length 744
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Narcolepsy Narcolepsy rs104894574, rs387906655 19629137
Unknown
Disease term Disease name Evidence References Source
Multiple Congenital Anomalies multiple congenital anomalies/dysmorphic syndrome GenCC
Associations from Text Mining
Disease Name Relationship Type References
Auriculoosteodysplasia Associate 33530447
Colonic Neoplasms Associate 39350118
Colorectal Neoplasms Associate 36847071
Colorectal Neoplasms Inhibit 39350118
Retinal Diseases Associate 35730627
Spondylocostal dysostosis autosomal recessive Associate 33530447