Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79668
Gene name Gene Name - the full gene name approved by the HGNC.	Poly(ADP-ribose) polymerase family member 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PARP8
Synonyms (NCBI Gene) Gene synonyms aliases	ARTD16, pART16
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q11.1

Show/Hide all(138)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000732	hsa-miR-145-5p	Review	19574400
MIRT1214591	hsa-miR-1231	CLIP-seq
MIRT1214592	hsa-miR-1286	CLIP-seq
MIRT1214593	hsa-miR-1323	CLIP-seq
MIRT1214594	hsa-miR-1324	CLIP-seq
MIRT1214595	hsa-miR-2276	CLIP-seq
MIRT1214596	hsa-miR-28-3p	CLIP-seq
MIRT1214597	hsa-miR-3129-3p	CLIP-seq
MIRT1214598	hsa-miR-3148	CLIP-seq
MIRT1214599	hsa-miR-3149	CLIP-seq
MIRT1214600	hsa-miR-3188	CLIP-seq
MIRT1214601	hsa-miR-346	CLIP-seq
MIRT1214602	hsa-miR-3655	CLIP-seq
MIRT1214603	hsa-miR-3662	CLIP-seq
MIRT1214604	hsa-miR-376a	CLIP-seq
MIRT1214605	hsa-miR-376b	CLIP-seq
MIRT1214606	hsa-miR-3908	CLIP-seq
MIRT1214607	hsa-miR-3942-5p	CLIP-seq
MIRT1214608	hsa-miR-4288	CLIP-seq
MIRT1214609	hsa-miR-4446-3p	CLIP-seq
MIRT1214610	hsa-miR-4656	CLIP-seq
MIRT1214611	hsa-miR-4659a-3p	CLIP-seq
MIRT1214612	hsa-miR-4659b-3p	CLIP-seq
MIRT1214613	hsa-miR-4680-3p	CLIP-seq
MIRT1214614	hsa-miR-4703-5p	CLIP-seq
MIRT1214615	hsa-miR-4722-5p	CLIP-seq
MIRT1214616	hsa-miR-4766-3p	CLIP-seq
MIRT1214617	hsa-miR-4772-3p	CLIP-seq
MIRT1214618	hsa-miR-548n	CLIP-seq
MIRT1214619	hsa-miR-548o	CLIP-seq
MIRT1214620	hsa-miR-578	CLIP-seq
MIRT1214621	hsa-miR-583	CLIP-seq
MIRT1214622	hsa-miR-632	CLIP-seq
MIRT1214623	hsa-miR-664	CLIP-seq
MIRT1214624	hsa-miR-1238	CLIP-seq
MIRT1214625	hsa-miR-1277	CLIP-seq
MIRT1214626	hsa-miR-141	CLIP-seq
MIRT1214627	hsa-miR-1972	CLIP-seq
MIRT1214628	hsa-miR-198	CLIP-seq
MIRT1214629	hsa-miR-200a	CLIP-seq
MIRT1214630	hsa-miR-216a	CLIP-seq
MIRT1214631	hsa-miR-297	CLIP-seq
MIRT1214632	hsa-miR-3121-3p	CLIP-seq
MIRT1214633	hsa-miR-3153	CLIP-seq
MIRT1214634	hsa-miR-3657	CLIP-seq
MIRT1214603	hsa-miR-3662	CLIP-seq
MIRT1214635	hsa-miR-371-5p	CLIP-seq
MIRT1214636	hsa-miR-371b-5p	CLIP-seq
MIRT1214637	hsa-miR-374a	CLIP-seq
MIRT1214638	hsa-miR-374b	CLIP-seq
MIRT1214604	hsa-miR-376a	CLIP-seq
MIRT1214605	hsa-miR-376b	CLIP-seq
MIRT1214639	hsa-miR-4275	CLIP-seq
MIRT1214640	hsa-miR-4277	CLIP-seq
MIRT1214641	hsa-miR-4330	CLIP-seq
MIRT1214642	hsa-miR-4648	CLIP-seq
MIRT1214643	hsa-miR-4654	CLIP-seq
MIRT1214644	hsa-miR-4668-5p	CLIP-seq
MIRT1214645	hsa-miR-4669	CLIP-seq
MIRT1214646	hsa-miR-4698	CLIP-seq
MIRT1214647	hsa-miR-4712-5p	CLIP-seq
MIRT1214648	hsa-miR-4769-5p	CLIP-seq
MIRT1214649	hsa-miR-4775	CLIP-seq
MIRT1214650	hsa-miR-4778-3p	CLIP-seq
MIRT1214651	hsa-miR-520d-5p	CLIP-seq
MIRT1214652	hsa-miR-524-5p	CLIP-seq
MIRT1214653	hsa-miR-549	CLIP-seq
MIRT1214654	hsa-miR-567	CLIP-seq
MIRT1214655	hsa-miR-590-3p	CLIP-seq
MIRT1214656	hsa-miR-606	CLIP-seq
MIRT1214657	hsa-miR-770-5p	CLIP-seq
MIRT2061763	hsa-let-7a	CLIP-seq
MIRT2061764	hsa-let-7b	CLIP-seq
MIRT2061765	hsa-let-7c	CLIP-seq
MIRT2061766	hsa-let-7d	CLIP-seq
MIRT2061767	hsa-let-7e	CLIP-seq
MIRT2061768	hsa-let-7f	CLIP-seq
MIRT2061769	hsa-let-7g	CLIP-seq
MIRT2061770	hsa-let-7i	CLIP-seq
MIRT2061771	hsa-miR-105	CLIP-seq
MIRT2061772	hsa-miR-1206	CLIP-seq
MIRT2061773	hsa-miR-1262	CLIP-seq
MIRT2061774	hsa-miR-142-3p	CLIP-seq
MIRT2061775	hsa-miR-196a	CLIP-seq
MIRT2061776	hsa-miR-196b	CLIP-seq
MIRT2061777	hsa-miR-202	CLIP-seq
MIRT2061778	hsa-miR-3127-3p	CLIP-seq
MIRT2061779	hsa-miR-3145-5p	CLIP-seq
MIRT2061780	hsa-miR-369-3p	CLIP-seq
MIRT1214635	hsa-miR-371-5p	CLIP-seq
MIRT1214636	hsa-miR-371b-5p	CLIP-seq
MIRT1214637	hsa-miR-374a	CLIP-seq
MIRT1214638	hsa-miR-374b	CLIP-seq
MIRT2061781	hsa-miR-374c	CLIP-seq
MIRT2061782	hsa-miR-376c	CLIP-seq
MIRT2061783	hsa-miR-4255	CLIP-seq
MIRT2061784	hsa-miR-4259	CLIP-seq
MIRT2061785	hsa-miR-4274	CLIP-seq
MIRT2061786	hsa-miR-4279	CLIP-seq
MIRT2061787	hsa-miR-4280	CLIP-seq
MIRT2061788	hsa-miR-431	CLIP-seq
MIRT2061789	hsa-miR-4455	CLIP-seq
MIRT2061790	hsa-miR-4458	CLIP-seq
MIRT2061791	hsa-miR-4500	CLIP-seq
MIRT2061792	hsa-miR-4519	CLIP-seq
MIRT1214611	hsa-miR-4659a-3p	CLIP-seq
MIRT1214612	hsa-miR-4659b-3p	CLIP-seq
MIRT1214613	hsa-miR-4680-3p	CLIP-seq
MIRT2061793	hsa-miR-4701-3p	CLIP-seq
MIRT1214649	hsa-miR-4775	CLIP-seq
MIRT1214650	hsa-miR-4778-3p	CLIP-seq
MIRT2061794	hsa-miR-4793-5p	CLIP-seq
MIRT2061795	hsa-miR-511	CLIP-seq
MIRT2061796	hsa-miR-526b	CLIP-seq
MIRT2061797	hsa-miR-576-3p	CLIP-seq
MIRT2061798	hsa-miR-579	CLIP-seq
MIRT2061799	hsa-miR-609	CLIP-seq
MIRT2061800	hsa-miR-655	CLIP-seq
MIRT2061801	hsa-miR-656	CLIP-seq
MIRT2061802	hsa-miR-885-5p	CLIP-seq
MIRT2061803	hsa-miR-942	CLIP-seq
MIRT2061804	hsa-miR-98	CLIP-seq
MIRT2290149	hsa-miR-3163	CLIP-seq
MIRT2290150	hsa-miR-4699-3p	CLIP-seq
MIRT1214651	hsa-miR-520d-5p	CLIP-seq
MIRT1214652	hsa-miR-524-5p	CLIP-seq
MIRT2290151	hsa-miR-1914	CLIP-seq
MIRT1214607	hsa-miR-3942-5p	CLIP-seq
MIRT1214639	hsa-miR-4275	CLIP-seq
MIRT2290152	hsa-miR-4684-3p	CLIP-seq
MIRT1214614	hsa-miR-4703-5p	CLIP-seq
MIRT2290153	hsa-miR-657	CLIP-seq
MIRT2455941	hsa-miR-138	CLIP-seq
MIRT2290149	hsa-miR-3163	CLIP-seq
MIRT2455942	hsa-miR-3650	CLIP-seq
MIRT2455943	hsa-miR-3688-5p	CLIP-seq
MIRT2455944	hsa-miR-548c-3p	CLIP-seq
MIRT2455945	hsa-miR-644	CLIP-seq

Show/Hide all(6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003950	Function	NAD+ ADP-ribosyltransferase activity	IBA	21873635
GO:0005622	Component	Intracellular anatomical structure	IBA	21873635
GO:0006471	Process	Protein ADP-ribosylation	IBA	21873635
GO:0070213	Process	Protein auto-ADP-ribosylation	IDA	25043379
GO:0140289	Process	Protein mono-ADP-ribosylation	IDA	25043379
GO:1990404	Function	Protein ADP-ribosylase activity	IDA	25043379

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein

UniProt ID

Q8N3A8

Protein name

Protein mono-ADP-ribosyltransferase PARP8 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) (Poly [ADP-ribose] polymerase 8) (PARP-8)

Protein function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00644	PARP	675 → 817	Poly(ADP-ribose) polymerase catalytic domain	Family

Sequence

MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPRSVSYSVHVSEDY
PDNTYVSSSENDEDVLVTTEPIPVIFHRIATELRKTNDINCCLSIKSKLQKENGEESRQN
STVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSAVREIYGPHAVSLREYGAIDD
VDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVPTVDVFQISTKERFGL
GHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKS
KSKLKSEQDGISKTHKLLRRTCSSTVKTDDVCVTKSHRTFGRSLSSDPRAEQAMTAIKSH
KLLNRPCPAAVKSEECLTLKSHRLLTRSCSGDPRCEHNTNLKPHKLLSRSYSSNLRMEEL
YGLKNHKLLSKSYSSAPKSSKTELFKEPNAEGRRLSLTSGLIGILTPSSSSSSQLAPNGA
KCIPVRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLRPTVCERELCVFAFQT
LGVMNEAADEIATGAQVVDLLVSMCRSALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKK
NYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQ
LKFMHTPHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRL
QLHGAMYGSGIYLSPMSSISFGYSGMNKKQKVSAKDEPASSSKSSNTSQSQKKGQQSQFL
QSRNLKCIALCEVITSSDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIH
KEILRVIGNQTATG

Sequence length

854

Interactions

View interactions

	Reactome
			Nicotinamide salvaging

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451 View all (71 more)	29059683
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800 View all (467 more)

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	Source
Unknown
Hyperopia	Hyperopia		GWAS
Schizophrenia	Schizophrenia		GWAS
Diabetes	Diabetes		GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Acne Vulgaris	Associate	37018476
Disease	Associate	37239316
Prostatic Neoplasms	Associate	37239316
Uveal melanoma	Associate	37033251, 37142279

PARP8 (poly(ADP-ribose) polymerase family member 8)