Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79625
Gene name Gene Name - the full gene name approved by the HGNC.	Neuron derived neurotrophic factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NDNF
Synonyms (NCBI Gene) Gene synonyms aliases	C4orf31, HH25, NORD
Disease Acronyms (UniProt) Disease acronyms from UniProt database	HH25
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q27

Show/Hide all(116)

miRTarBase ID	miRNA	Experiments	Reference
MIRT655970	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT655969	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT655968	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT655967	hsa-miR-3183	HITS-CLIP	23824327
MIRT655966	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT655964	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT655965	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT655963	hsa-miR-1260a	HITS-CLIP	23824327
MIRT655962	hsa-miR-1260b	HITS-CLIP	23824327
MIRT655961	hsa-miR-578	HITS-CLIP	23824327
MIRT655960	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT527999	hsa-miR-4714-5p	PAR-CLIP	22012620
MIRT527998	hsa-miR-146a-3p	PAR-CLIP	22012620
MIRT527997	hsa-miR-4670-3p	PAR-CLIP	22012620
MIRT527996	hsa-miR-6715b-3p	PAR-CLIP	22012620
MIRT527995	hsa-miR-452-3p	PAR-CLIP	22012620
MIRT527994	hsa-miR-6844	PAR-CLIP	22012620
MIRT527993	hsa-miR-607	PAR-CLIP	22012620
MIRT527992	hsa-miR-1305	PAR-CLIP	22012620
MIRT527991	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT445363	hsa-miR-224-3p	PAR-CLIP	22100165
MIRT445362	hsa-miR-522-3p	PAR-CLIP	22100165
MIRT445361	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT445359	hsa-miR-4635	PAR-CLIP	22100165
MIRT445360	hsa-miR-3185	PAR-CLIP	22100165
MIRT445358	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT445363	hsa-miR-224-3p	PAR-CLIP	22100165
MIRT445362	hsa-miR-522-3p	PAR-CLIP	22100165
MIRT445361	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT445359	hsa-miR-4635	PAR-CLIP	22100165
MIRT445360	hsa-miR-3185	PAR-CLIP	22100165
MIRT445358	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT655970	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT655969	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT655968	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT655967	hsa-miR-3183	HITS-CLIP	23824327
MIRT655966	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT655964	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT655965	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT655963	hsa-miR-1260a	HITS-CLIP	23824327
MIRT655962	hsa-miR-1260b	HITS-CLIP	23824327
MIRT655961	hsa-miR-578	HITS-CLIP	23824327
MIRT655960	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT527999	hsa-miR-4714-5p	PAR-CLIP	22012620
MIRT527998	hsa-miR-146a-3p	PAR-CLIP	22012620
MIRT527997	hsa-miR-4670-3p	PAR-CLIP	22012620
MIRT527996	hsa-miR-6715b-3p	PAR-CLIP	22012620
MIRT527995	hsa-miR-452-3p	PAR-CLIP	22012620
MIRT527994	hsa-miR-6844	PAR-CLIP	22012620
MIRT527993	hsa-miR-607	PAR-CLIP	22012620
MIRT527992	hsa-miR-1305	PAR-CLIP	22012620
MIRT527991	hsa-miR-335-3p	PAR-CLIP	22012620
MIRT445363	hsa-miR-224-3p	PAR-CLIP	22100165
MIRT445362	hsa-miR-522-3p	PAR-CLIP	22100165
MIRT445361	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT445359	hsa-miR-4635	PAR-CLIP	22100165
MIRT445360	hsa-miR-3185	PAR-CLIP	22100165
MIRT445358	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT445363	hsa-miR-224-3p	PAR-CLIP	22100165
MIRT445362	hsa-miR-522-3p	PAR-CLIP	22100165
MIRT445361	hsa-miR-6507-5p	PAR-CLIP	22100165
MIRT445359	hsa-miR-4635	PAR-CLIP	22100165
MIRT445360	hsa-miR-3185	PAR-CLIP	22100165
MIRT445358	hsa-miR-4709-3p	PAR-CLIP	22100165
MIRT1178048	hsa-miR-1206	CLIP-seq
MIRT1178049	hsa-miR-139-5p	CLIP-seq
MIRT1178050	hsa-miR-3125	CLIP-seq
MIRT1178051	hsa-miR-3168	CLIP-seq
MIRT1178052	hsa-miR-33a	CLIP-seq
MIRT1178053	hsa-miR-33b	CLIP-seq
MIRT1178054	hsa-miR-3690	CLIP-seq
MIRT1178055	hsa-miR-3916	CLIP-seq
MIRT1178056	hsa-miR-4254	CLIP-seq
MIRT1178057	hsa-miR-4653-3p	CLIP-seq
MIRT1178058	hsa-miR-4790-3p	CLIP-seq
MIRT1178059	hsa-miR-4797-5p	CLIP-seq
MIRT1178060	hsa-miR-513a-3p	CLIP-seq
MIRT2438966	hsa-miR-1324	CLIP-seq
MIRT2438967	hsa-miR-4711-5p	CLIP-seq
MIRT1178052	hsa-miR-33a	CLIP-seq
MIRT1178053	hsa-miR-33b	CLIP-seq
MIRT2454964	hsa-miR-4265	CLIP-seq
MIRT2454965	hsa-miR-4296	CLIP-seq
MIRT2454966	hsa-miR-4322	CLIP-seq
MIRT2454967	hsa-miR-4455	CLIP-seq
MIRT2454968	hsa-miR-609	CLIP-seq
MIRT1178052	hsa-miR-33a	CLIP-seq
MIRT1178053	hsa-miR-33b	CLIP-seq
MIRT2454964	hsa-miR-4265	CLIP-seq
MIRT2454965	hsa-miR-4296	CLIP-seq
MIRT2454966	hsa-miR-4322	CLIP-seq
MIRT2454967	hsa-miR-4455	CLIP-seq
MIRT2454968	hsa-miR-609	CLIP-seq
MIRT2438966	hsa-miR-1324	CLIP-seq
MIRT2579067	hsa-miR-205	CLIP-seq
MIRT2579068	hsa-miR-335	CLIP-seq
MIRT2579069	hsa-miR-3675-5p	CLIP-seq
MIRT2579070	hsa-miR-4704-5p	CLIP-seq
MIRT2438967	hsa-miR-4711-5p	CLIP-seq
MIRT2579071	hsa-miR-4773	CLIP-seq
MIRT2579072	hsa-miR-486-3p	CLIP-seq
MIRT2579073	hsa-miR-603	CLIP-seq
MIRT2438966	hsa-miR-1324	CLIP-seq
MIRT2579067	hsa-miR-205	CLIP-seq
MIRT2686018	hsa-miR-329	CLIP-seq
MIRT2579068	hsa-miR-335	CLIP-seq
MIRT2686019	hsa-miR-362-3p	CLIP-seq
MIRT2579069	hsa-miR-3675-5p	CLIP-seq
MIRT2686020	hsa-miR-3941	CLIP-seq
MIRT2686021	hsa-miR-410	CLIP-seq
MIRT2579070	hsa-miR-4704-5p	CLIP-seq
MIRT2438967	hsa-miR-4711-5p	CLIP-seq
MIRT2579071	hsa-miR-4773	CLIP-seq
MIRT2686022	hsa-miR-4789-5p	CLIP-seq
MIRT2579072	hsa-miR-486-3p	CLIP-seq
MIRT2579073	hsa-miR-603	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IDA	24706764
GO:0001764	Process	Neuron migration	IDA	20969804
GO:0002931	Process	Response to ischemia	IEA
GO:0005539	Function	Glycosaminoglycan binding	ISS
GO:0005576	Component	Extracellular region	IDA	20969804
GO:0005615	Component	Extracellular space	IDA	31883645
GO:0007263	Process	Nitric oxide mediated signal transduction	IDA	24706764
GO:0008201	Function	Heparin binding	IBA	21873635
GO:0008201	Function	Heparin binding	ISS
GO:0010811	Process	Positive regulation of cell-substrate adhesion	ISS
GO:0010976	Process	Positive regulation of neuron projection development	IDA	20969804
GO:0019800	Process	Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	IBA	21873635
GO:0019800	Process	Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	ISS
GO:0021828	Process	Gonadotrophin-releasing hormone neuronal migration to the hypothalamus	ISS
GO:0030198	Process	Extracellular matrix organization	IBA	21873635
GO:0030198	Process	Extracellular matrix organization	ISS
GO:0031012	Component	Extracellular matrix	ISS
GO:0043524	Process	Negative regulation of neuron apoptotic process	IDA	20969804
GO:0044344	Process	Cellular response to fibroblast growth factor stimulus	IMP	31883645
GO:0061042	Process	Vascular wound healing	ISS
GO:0071456	Process	Cellular response to hypoxia	IDA	24706764
GO:2000352	Process	Negative regulation of endothelial cell apoptotic process	IDA	24706764

MIM	HGNC	e!Ensembl
616506	26256	ENSG00000173376

Protein

UniProt ID

Q8TB73

Protein name

Protein NDNF (Neuron-derived neurotrophic factor)

Protein function

Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645). Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10179	DUF2369	291 → 383	Uncharacterised conserved protein (DUF2369)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in neurons along the gonadotropin-releasing hormone (GnRH) expressing neurons migratory route. {ECO:0000269|PubMed:31883645}.

Sequence

MVLLHWCLLWLLFPLSSRTQKLPTRDEELFQMQIRDKAFFHDSSVIPDGAEISSYLFRDT
PKRYFFVVEEDNTPLSVTVTPCDAPLEWKLSLQELPEDRSGEGSGDLEPLEQQKQQIINE
EGTELFSYKGNDVEYFISSSSPSGLYQLDLLSTEKDTHFKVYATTTPESDQPYPELPYDP
RVDVTSLGRTTVTLAWKPSPTASLLKQPIQYCVVINKEHNFKSLCAVEAKLSADDAFMMA
PKPGLDFSPFDFAHFGFPSDNSGKERSFQAKPSPKLGRHVYSRPKVDIQKICIGNKNIFT
VSDLKPDTQYYFDVFVVNINSNMSTAYVGTFARTKEEAKQKTVELKDGKITDVFVKRKGA
KFLRFAPVSSHQKVTFFIHSCLDAVQIQVRRDGKLLLSQNVEGIQQFQLRGKPKAKYLVR
LKGNKKGASMLKILATTRPTKQSFPSLPEDTRIKAFDKLRTCSSATVAWLGTQERNKFCI
YKKEVDDNYNEDQKKREQNQCLGPDIRKKSEKVLCKYFHSQNLQKAVTTETIKGLQPGKS
YLLDVYVIGHGGHSVKYQSKVVKTRKFC

Sequence length

568

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease term	Disease name	References	Source
Unknown
Endometriosis	Endometriosis	20864642	ClinVar
Hypogonadotropic Hypogonadism	hypogonadotropic hypogonadism 25 with anosmia		GenCC
Kallmann Syndrome	Kallmann syndrome		GenCC

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Diabetic Nephropathies	Associate	36092962
Psychotic Disorders	Inhibit	38340697

NDNF (neuron derived neurotrophic factor)