Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79608
Gene name	RIC3 acetylcholine receptor chaperone
Gene symbol	RIC3
Synonyms (NCBI Gene)	AYST720PRO1385RIC-3
Chromosome	11
Chromosome location	11p15.4
Summary	This gene encodes a member of the resistance to inhibitors of cholinesterase 3-like family which functions as a chaperone of specific 5-hydroxytryptamine type 3 receptor and nicotinic acetylcholine receptor subtypes. The encoded protein influences the fol

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miRTarBase ID	miRNA	Experiments
MIRT1306399	hsa-miR-125a-3p	CLIP-seq
MIRT1306400	hsa-miR-1266	CLIP-seq
MIRT739891	hsa-miR-2117	CLIP-seq
MIRT739890	hsa-miR-2276	CLIP-seq
MIRT739887	hsa-miR-3145-5p	CLIP-seq
MIRT1306401	hsa-miR-3664-3p	CLIP-seq
MIRT1306402	hsa-miR-3913-3p	CLIP-seq
MIRT1306403	hsa-miR-3934	CLIP-seq
MIRT1306404	hsa-miR-4290	CLIP-seq
MIRT1306405	hsa-miR-4504	CLIP-seq
MIRT1306406	hsa-miR-4518	CLIP-seq
MIRT1306407	hsa-miR-455-5p	CLIP-seq
MIRT1306408	hsa-miR-4680-5p	CLIP-seq
MIRT739889	hsa-miR-4772-3p	CLIP-seq
MIRT1306409	hsa-miR-489	CLIP-seq
MIRT739888	hsa-miR-508-5p	CLIP-seq
MIRT1306410	hsa-miR-542-3p	CLIP-seq
MIRT1306411	hsa-miR-764	CLIP-seq
MIRT1306412	hsa-miR-877	CLIP-seq
MIRT1306413	hsa-miR-1228	CLIP-seq
MIRT1306414	hsa-miR-377	CLIP-seq
MIRT1306415	hsa-miR-4716-5p	CLIP-seq
MIRT1306416	hsa-miR-5096	CLIP-seq
MIRT1306413	hsa-miR-1228	CLIP-seq
MIRT1306400	hsa-miR-1266	CLIP-seq
MIRT1306417	hsa-miR-1299	CLIP-seq
MIRT1306418	hsa-miR-146b-3p	CLIP-seq
MIRT1306419	hsa-miR-296-5p	CLIP-seq
MIRT1306420	hsa-miR-3148	CLIP-seq
MIRT1306421	hsa-miR-3199	CLIP-seq
MIRT1306422	hsa-miR-329	CLIP-seq
MIRT1306423	hsa-miR-3591-5p	CLIP-seq
MIRT1306424	hsa-miR-362-3p	CLIP-seq
MIRT1306401	hsa-miR-3664-3p	CLIP-seq
MIRT1306425	hsa-miR-3682-5p	CLIP-seq
MIRT1306414	hsa-miR-377	CLIP-seq
MIRT1306426	hsa-miR-3941	CLIP-seq
MIRT1306427	hsa-miR-4255	CLIP-seq
MIRT1306404	hsa-miR-4290	CLIP-seq
MIRT1306428	hsa-miR-4468	CLIP-seq
MIRT1306406	hsa-miR-4518	CLIP-seq
MIRT1306407	hsa-miR-455-5p	CLIP-seq
MIRT1306429	hsa-miR-4633-3p	CLIP-seq
MIRT1306430	hsa-miR-4652-5p	CLIP-seq
MIRT1306431	hsa-miR-4668-5p	CLIP-seq
MIRT1306408	hsa-miR-4680-5p	CLIP-seq
MIRT1306415	hsa-miR-4716-5p	CLIP-seq
MIRT1306432	hsa-miR-4722-5p	CLIP-seq
MIRT1306433	hsa-miR-4735-5p	CLIP-seq
MIRT1306434	hsa-miR-4740-5p	CLIP-seq
MIRT1306435	hsa-miR-4753-5p	CLIP-seq
MIRT1306436	hsa-miR-4775	CLIP-seq
MIRT1306437	hsa-miR-4782-5p	CLIP-seq
MIRT1306416	hsa-miR-5096	CLIP-seq
MIRT1306438	hsa-miR-513b	CLIP-seq
MIRT1306439	hsa-miR-516b	CLIP-seq
MIRT1306440	hsa-miR-526b	CLIP-seq
MIRT1306441	hsa-miR-590-3p	CLIP-seq
MIRT1306442	hsa-miR-603	CLIP-seq
MIRT1306443	hsa-miR-626	CLIP-seq
MIRT2090764	hsa-miR-103a	CLIP-seq
MIRT2090765	hsa-miR-107	CLIP-seq
MIRT2090766	hsa-miR-1827	CLIP-seq
MIRT2090767	hsa-miR-4452	CLIP-seq
MIRT2090768	hsa-miR-654-3p	CLIP-seq
MIRT2315436	hsa-miR-1237	CLIP-seq
MIRT2315437	hsa-miR-1343	CLIP-seq
MIRT2315438	hsa-miR-19a	CLIP-seq
MIRT2315439	hsa-miR-19b	CLIP-seq
MIRT2315440	hsa-miR-29a	CLIP-seq
MIRT2315441	hsa-miR-29b	CLIP-seq
MIRT2315442	hsa-miR-29c	CLIP-seq
MIRT2315443	hsa-miR-3176	CLIP-seq
MIRT2315444	hsa-miR-3650	CLIP-seq
MIRT2315445	hsa-miR-3663-3p	CLIP-seq
MIRT2315446	hsa-miR-3670	CLIP-seq
MIRT2315447	hsa-miR-378g	CLIP-seq
MIRT2315448	hsa-miR-3922-3p	CLIP-seq
MIRT1306403	hsa-miR-3934	CLIP-seq
MIRT2315449	hsa-miR-4303	CLIP-seq
MIRT1306407	hsa-miR-455-5p	CLIP-seq
MIRT2315450	hsa-miR-4733-3p	CLIP-seq
MIRT2315451	hsa-miR-516a-3p	CLIP-seq
MIRT1306410	hsa-miR-542-3p	CLIP-seq
MIRT2315452	hsa-miR-552	CLIP-seq
MIRT2432743	hsa-miR-1229	CLIP-seq
MIRT2432744	hsa-miR-1236	CLIP-seq
MIRT739891	hsa-miR-2117	CLIP-seq
MIRT2432745	hsa-miR-4273	CLIP-seq
MIRT2432746	hsa-miR-4698	CLIP-seq
MIRT2432747	hsa-miR-4753-3p	CLIP-seq
MIRT2432748	hsa-miR-942	CLIP-seq
MIRT2432743	hsa-miR-1229	CLIP-seq
MIRT2432744	hsa-miR-1236	CLIP-seq
MIRT739891	hsa-miR-2117	CLIP-seq
MIRT2432745	hsa-miR-4273	CLIP-seq
MIRT2432746	hsa-miR-4698	CLIP-seq
MIRT2432747	hsa-miR-4753-3p	CLIP-seq
MIRT2432748	hsa-miR-942	CLIP-seq
MIRT2458221	hsa-miR-1184	CLIP-seq
MIRT2458222	hsa-miR-1301	CLIP-seq
MIRT2458223	hsa-miR-3074-5p	CLIP-seq
MIRT2458224	hsa-miR-4660	CLIP-seq
MIRT2458225	hsa-miR-4757-5p	CLIP-seq
MIRT2458226	hsa-miR-5047	CLIP-seq
MIRT2458222	hsa-miR-1301	CLIP-seq
MIRT2611694	hsa-miR-296-3p	CLIP-seq
MIRT2458226	hsa-miR-5047	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0006457	Process	Protein folding	IEA
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007271	Process	Synaptic transmission, cholinergic	IBA
GO:0007271	Process	Synaptic transmission, cholinergic	IEA
GO:0016020	Component	Membrane	IEA
GO:0033130	Function	Acetylcholine receptor binding	IEA
GO:0034394	Process	Protein localization to cell surface	IBA
GO:0043005	Component	Neuron projection	IBA
GO:0043025	Component	Neuronal cell body	IBA
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA
GO:0044183	Function	Protein folding chaperone	IEA
GO:0045202	Component	Synapse	IEA
GO:0065003	Process	Protein-containing complex assembly	IEA
GO:2000010	Process	Positive regulation of protein localization to cell surface	IDA	32204458

MIM	HGNC	e!Ensembl
610509	30338	ENSG00000166405

Q7Z5B4

Protein name

Protein RIC-3 (Resistant to inhibitor of cholinesterase 3)

Protein function

Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors (PubMed:12821669, PubMed:15504725, PubMed:16120769, PubMed:18691158, PubMed:32204458

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15361	RIC3	15 → 166	Resistance to inhibitors of cholinesterase homologue 3	Family

Tissue specificity

TISSUE SPECIFICITY: Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar dis

Sequence

MAYSTVQRVALASGLVLALSLLLPKAFLSRGKRQEPPPTPEGKLGRFPPMMHHHQAPSDG
QTPGARFQRSHLAEAFAKAKGSGGGAGGGGSGRGLMGQIIPIYGFGIFLYILYILFKLSK
GKTTAEDGKCYTAMPGNTHRKITSFELAQLQEKLKETEAAMEKLINRVGPNGESRAQTVT
SDQEKRLLHQLREITRVMKEGKFIDRFSPEKEAEEAPYMEDWEGYPEETYPIYDLSDCIK
RRQETILVDYPDPKELSAEEIAERMGMIEEEESDHLGWESLPTDPRAQEDNSVTSCDPKP
ETCSCCFHEDEDPAVLAENAGFSADSYPEQEETTKEEWSQDFKDEGLGISTDKAYTGSML
RKRNPQGLE

Sequence length

369

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
RIC3-related disorder	Likely benign	rs145965152	RCV003934169

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Leukoencephalopathies	Associate	23412934
Multiple Sclerosis	Associate	23412934
Neoplasms	Associate	30914738
Obesity	Associate	16443771
Pancreatic Neoplasms	Associate	39639217

RIC3 (RIC3 acetylcholine receptor chaperone)