CORO7 (coronin 7)

Gene

• Entrez ID: 79585
• Gene name: Coronin 7
• Gene symbol: CORO7
• Synonyms (NCBI Gene): 0610011B16Rik, CRN7, POD1
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has tw

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018155	hsa-miR-335-5p	Microarray	18185580
MIRT049245	hsa-miR-92a-3p	CLASH	23622248
MIRT696403	hsa-miR-606	HITS-CLIP	23313552
MIRT696402	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT696401	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT696400	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT696398	hsa-miR-4635	HITS-CLIP	23313552
MIRT696399	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT696397	hsa-miR-6131	HITS-CLIP	23313552
MIRT696396	hsa-miR-7158-3p	HITS-CLIP	23313552
MIRT696395	hsa-miR-203b-3p	HITS-CLIP	23313552
MIRT696394	hsa-miR-548s	HITS-CLIP	23313552
MIRT696393	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT696392	hsa-miR-588	HITS-CLIP	23313552
MIRT696391	hsa-miR-4435	HITS-CLIP	23313552
MIRT696390	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT484652	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT484651	hsa-miR-6865-3p	PAR-CLIP	23592263
MIRT484650	hsa-miR-3620-3p	PAR-CLIP	23592263
MIRT484649	hsa-miR-3151-3p	PAR-CLIP	23592263
MIRT484648	hsa-miR-3192-3p	PAR-CLIP	23592263
MIRT696403	hsa-miR-606	HITS-CLIP	23313552
MIRT696402	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT696401	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT696400	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT696398	hsa-miR-4635	HITS-CLIP	23313552
MIRT696399	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT696397	hsa-miR-6131	HITS-CLIP	23313552
MIRT696396	hsa-miR-7158-3p	HITS-CLIP	23313552
MIRT696395	hsa-miR-203b-3p	HITS-CLIP	23313552
MIRT696394	hsa-miR-548s	HITS-CLIP	23313552
MIRT696393	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT696392	hsa-miR-588	HITS-CLIP	23313552
MIRT696391	hsa-miR-4435	HITS-CLIP	23313552
MIRT696390	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT484652	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT484651	hsa-miR-6865-3p	PAR-CLIP	23592263
MIRT484650	hsa-miR-3620-3p	PAR-CLIP	23592263
MIRT484649	hsa-miR-3151-3p	PAR-CLIP	23592263
MIRT484648	hsa-miR-3192-3p	PAR-CLIP	23592263
MIRT904758	hsa-miR-125a-3p	CLIP-seq
MIRT904759	hsa-miR-1294	CLIP-seq
MIRT904760	hsa-miR-2114	CLIP-seq
MIRT904761	hsa-miR-3665	CLIP-seq
MIRT904762	hsa-miR-3689d	CLIP-seq
MIRT904763	hsa-miR-4466	CLIP-seq
MIRT904764	hsa-miR-4476	CLIP-seq
MIRT904765	hsa-miR-4488	CLIP-seq
MIRT904766	hsa-miR-4640-5p	CLIP-seq
MIRT904767	hsa-miR-4697-5p	CLIP-seq
MIRT904768	hsa-miR-4710	CLIP-seq
MIRT904769	hsa-miR-4726-5p	CLIP-seq
MIRT904770	hsa-miR-4736	CLIP-seq
MIRT904771	hsa-miR-4767	CLIP-seq
MIRT904772	hsa-miR-4795-5p	CLIP-seq
MIRT904773	hsa-miR-552	CLIP-seq
MIRT904774	hsa-miR-675	CLIP-seq
MIRT904775	hsa-miR-764	CLIP-seq
MIRT904776	hsa-miR-885-3p	CLIP-seq
MIRT1968323	hsa-miR-3130-3p	CLIP-seq
MIRT1968324	hsa-miR-3146	CLIP-seq
MIRT1968325	hsa-miR-331-3p	CLIP-seq
MIRT1968326	hsa-miR-3620	CLIP-seq
MIRT1968327	hsa-miR-4258	CLIP-seq
MIRT904768	hsa-miR-4710	CLIP-seq
MIRT1968328	hsa-miR-621	CLIP-seq
MIRT1968329	hsa-miR-628-5p	CLIP-seq
MIRT904759	hsa-miR-1294	CLIP-seq
MIRT2204144	hsa-miR-15a	CLIP-seq
MIRT2204145	hsa-miR-15b	CLIP-seq
MIRT2204146	hsa-miR-16	CLIP-seq
MIRT2204147	hsa-miR-195	CLIP-seq
MIRT904762	hsa-miR-3689d	CLIP-seq
MIRT2204148	hsa-miR-424	CLIP-seq
MIRT2204149	hsa-miR-4468	CLIP-seq
MIRT904765	hsa-miR-4488	CLIP-seq
MIRT904767	hsa-miR-4697-5p	CLIP-seq
MIRT904768	hsa-miR-4710	CLIP-seq
MIRT2204150	hsa-miR-497	CLIP-seq
MIRT904759	hsa-miR-1294	CLIP-seq
MIRT904762	hsa-miR-3689d	CLIP-seq
MIRT904765	hsa-miR-4488	CLIP-seq
MIRT904767	hsa-miR-4697-5p	CLIP-seq
MIRT904768	hsa-miR-4710	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0003779	Function	Actin binding	IDA	24768539
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	21130766, 24768539
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005794	Component	Golgi apparatus	ISS
GO:0005802	Component	Trans-Golgi network	IDA	24768539
GO:0005829	Component	Cytosol	IEA
GO:0006895	Process	Golgi to endosome transport	IMP	24768539
GO:0007015	Process	Actin filament organization	IEA
GO:0007015	Process	Actin filament organization	IEA
GO:0007030	Process	Golgi organization	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016477	Process	Cell migration	IEA
GO:0030010	Process	Establishment of cell polarity	IEA
GO:0030041	Process	Actin filament polymerization	IMP	24768539
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0035332	Process	Positive regulation of hippo signaling	IMP	33162394

Other IDs

• MIM: 611668
• HGNC: 26161
• e!Ensembl: ENSG00000262246

Protein

• UniProt ID: P57737
• Protein name: Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog)
• Protein function: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08953	DUF1899	2 → 65	Domain of unknown function (DUF1899)	Domain
  PF00400	WD40	67 → 106	WD domain, G-beta repeat	Repeat
  PF00400	WD40	158 → 196	WD domain, G-beta repeat	Repeat
  PF16300	WD40_4	338 → 380		Repeat
  PF08953	DUF1899	468 → 532	Domain of unknown function (DUF1899)	Domain
  PF00400	WD40	584 → 623	WD domain, G-beta repeat	Repeat
  PF00400	WD40	629 → 665	WD domain, G-beta repeat	Repeat
  PF16300	WD40_4	808 → 852		Repeat

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed in the spleen, peripheral leukocytes, testes, brain, thymus and small intestine. {ECO:0000269|PubMed:21130766}.
• Sequence:

  MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPGVLGIVPL
  QGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGV
  VLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDG
  ALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREV
  KLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPV
  TQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPDT
  AGCVPATDPHSWWAGDNQQVQKVSLNPACRPHPSFTSCLVPPAEPLPDTAQPAVMETPVG
  DADASEGFSSPPSSLTSPSTPSSLGPSLSSTSGIGTSPSLRSLQSLLGPSSKFRHAQGTV
  LHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPT
  LQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSL
  RFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGR
  VRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAGG
  PLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHK
  GLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLS
  AEAWLQGANGQPWLLSLQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEELLNAM
  VAKLGNREDPLPQDSFEGVDEDEWD

• Sequence length: 925

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute megakaryoblastic leukemia	Uncertain significance	rs1555468179	RCV000202599
Mediastinal germ cell tumor	Uncertain significance	rs1555468179	RCV000202599

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinoma Pancreatic Ductal	Associate	37239355
Squamous Cell Carcinoma of Head and Neck	Associate	34884487