Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79582
Gene name	Sperm associated antigen 16
Gene symbol	SPAG16
Synonyms (NCBI Gene)	PF20WDR29
Chromosome	2
Chromosome location	2q34
Summary	Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic

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miRTarBase ID	miRNA	Experiments	Reference
MIRT712970	hsa-miR-3662	HITS-CLIP	19536157
MIRT712969	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT712968	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT712970	hsa-miR-3662	HITS-CLIP	19536157
MIRT712969	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT712968	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT643600	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT643599	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT643598	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT643597	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT643596	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT643595	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643594	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643593	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT643592	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT643591	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT643600	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT643599	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT643598	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT643597	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT643596	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT643595	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643594	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643593	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT643592	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT643591	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT712970	hsa-miR-3662	HITS-CLIP	19536157
MIRT712969	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT712968	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT712970	hsa-miR-3662	HITS-CLIP	19536157
MIRT712969	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT712968	hsa-miR-6828-5p	HITS-CLIP	19536157
MIRT643600	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT643599	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT643598	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT643597	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT643596	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT643595	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643594	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643593	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT643592	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT643591	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT643600	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT643599	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT643598	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT643597	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT643596	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT643595	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643594	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643593	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT643592	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT643591	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT2114208	hsa-miR-4528	CLIP-seq
MIRT2114209	hsa-miR-656	CLIP-seq
MIRT2433373	hsa-miR-1237	CLIP-seq
MIRT2433374	hsa-miR-1248	CLIP-seq
MIRT2433375	hsa-miR-1299	CLIP-seq
MIRT2433376	hsa-miR-1305	CLIP-seq
MIRT2433377	hsa-miR-3671	CLIP-seq
MIRT2433378	hsa-miR-4434	CLIP-seq
MIRT2433379	hsa-miR-4516	CLIP-seq
MIRT2433380	hsa-miR-4531	CLIP-seq
MIRT2433381	hsa-miR-4782-5p	CLIP-seq
MIRT2433382	hsa-miR-516b	CLIP-seq
MIRT2433383	hsa-miR-607	CLIP-seq
MIRT2114208	hsa-miR-4528	CLIP-seq
MIRT2114208	hsa-miR-4528	CLIP-seq
MIRT2114208	hsa-miR-4528	CLIP-seq
MIRT2114209	hsa-miR-656	CLIP-seq
MIRT2433373	hsa-miR-1237	CLIP-seq
MIRT2433374	hsa-miR-1248	CLIP-seq
MIRT2433375	hsa-miR-1299	CLIP-seq
MIRT2433378	hsa-miR-4434	CLIP-seq
MIRT2433379	hsa-miR-4516	CLIP-seq
MIRT2114208	hsa-miR-4528	CLIP-seq
MIRT2433380	hsa-miR-4531	CLIP-seq
MIRT2433381	hsa-miR-4782-5p	CLIP-seq
MIRT2691799	hsa-miR-4795-3p	CLIP-seq
MIRT2433382	hsa-miR-516b	CLIP-seq
MIRT2114209	hsa-miR-656	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005576	Component	Extracellular region	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005929	Component	Cilium	IEA
GO:0005930	Component	Axoneme	IEA
GO:0005930	Component	Axoneme	ISS
GO:0007288	Process	Sperm axoneme assembly	IEA
GO:0030030	Process	Cell projection organization	IEA
GO:0031514	Component	Motile cilium	IEA
GO:0035082	Process	Axoneme assembly	IBA
GO:0035082	Process	Axoneme assembly	IEA
GO:0035082	Process	Axoneme assembly	IMP	17699735
GO:0036126	Component	Sperm flagellum	IEA
GO:0042995	Component	Cell projection	IEA
GO:0060271	Process	Cilium assembly	IEA
GO:0060271	Process	Cilium assembly	ISS
GO:0090660	Process	Cerebrospinal fluid circulation	IEA
GO:0120197	Process	Mucociliary clearance	IEA
GO:1990716	Component	Axonemal central apparatus	IBA
GO:1990716	Component	Axonemal central apparatus	IEA

MIM	HGNC	e!Ensembl
612173	23225	ENSG00000144451

Q8N0X2

Protein name

Sperm-associated antigen 16 protein (Pf20 protein homolog)

Protein function

Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By sim

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	383 → 422	WD domain, G-beta repeat	Repeat
PF00400	WD40	426 → 464	WD domain, G-beta repeat	Repeat
PF00400	WD40	468 → 506	WD domain, G-beta repeat	Repeat
PF00400	WD40	510 → 548	WD domain, G-beta repeat	Repeat
PF00400	WD40	594 → 631	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Isoform 1 is detected in testis. Isoform 4 is detected in testis and brain, and at lower levels in kidney, heart, pancreas, thyroid, ovary, adrenal gland, spinal cord, trachea and liver. {ECO:0000269|PubMed:11867345, ECO:0000269|PubMed

Sequence

MAAQRGMPSSAVRVLEEALGMGLTAAGDARDTADAVAAEGAYYLEQVTITEASEDDYEYE
EIPDDNFSIPEGEEDLAKAIQMAQEQATDTEILERKTVLPSKHAVPEVIEDFLCNFLIKM
GMTRTLDCFQSEWYELIQKGVTELRTVGNVPDVYTQIMLLENENKNLKKDLKHYKQAADK
AREDLLKIQKERDFHRMHHKRIVQEKNKLINDLKGLKLHYASYEPTIRVLHEKHHTLLKE
KMLTSLERDKVVGQISGLQETLKKLQRGHSYHGPQIKVDHSREKENAPEGPTQKGLREAR
EQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSM
QPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKL
WDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDS
VNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDA
CGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLM
GHENEAHTVVFSHDGEILFSGGSDGTVRTWS

Sequence length

631

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Arthrogryposis multiplex congenita	Uncertain significance	rs535028567, rs1309397122	RCV000855518 RCV000855519
Fetal akinesia deformation sequence 1	Uncertain significance	rs535028567, rs1309397122	RCV000855518 RCV000855519
SPAG16-related disorder	Likely benign	rs368338111	RCV003921798

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	23956247, 36434627
Bipolar Disorder	Associate	24387768
Ciliary Motility Disorders	Associate	30300419, 34445527
Colorectal Neoplasms	Associate	37434131
Diabetes Mellitus Type 2	Associate	26634513
Infertility Male	Associate	22963137
Joint Diseases	Associate	23956247
Neuralgia	Associate	24387768
Neuroblastoma	Associate	23243203
Ocular Motility Disorders	Associate	22963137
Osteoporosis	Associate	34252604
Paralysis	Associate	22963137

SPAG16 (sperm associated antigen 16)