FSD1 (fibronectin type III and SPRY domain containing 1)

Gene

• Entrez ID: 79187
• Gene name: Fibronectin type III and SPRY domain containing 1
• Gene symbol: FSD1
• Synonyms (NCBI Gene): GLFND, MIR1
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protei

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1005441	hsa-miR-3150a-3p	CLIP-seq
MIRT1005442	hsa-miR-3175	CLIP-seq
MIRT1005443	hsa-miR-4258	CLIP-seq
MIRT1005444	hsa-miR-4707-3p	CLIP-seq
MIRT1005445	hsa-miR-491-5p	CLIP-seq
MIRT1005446	hsa-miR-939	CLIP-seq
MIRT1997985	hsa-miR-15a	CLIP-seq
MIRT1997986	hsa-miR-15b	CLIP-seq
MIRT1997987	hsa-miR-16	CLIP-seq
MIRT1997988	hsa-miR-195	CLIP-seq
MIRT1997989	hsa-miR-424	CLIP-seq
MIRT1997990	hsa-miR-497	CLIP-seq
MIRT2535473	hsa-miR-1254	CLIP-seq
MIRT2535474	hsa-miR-149	CLIP-seq
MIRT2535475	hsa-miR-3116	CLIP-seq
MIRT2535476	hsa-miR-4779	CLIP-seq
MIRT2535477	hsa-miR-542-3p	CLIP-seq
MIRT2535478	hsa-miR-550a	CLIP-seq
MIRT2535479	hsa-miR-661	CLIP-seq
MIRT2535480	hsa-miR-766	CLIP-seq
MIRT2535473	hsa-miR-1254	CLIP-seq
MIRT2535474	hsa-miR-149	CLIP-seq
MIRT2535475	hsa-miR-3116	CLIP-seq
MIRT2535476	hsa-miR-4779	CLIP-seq
MIRT2535477	hsa-miR-542-3p	CLIP-seq
MIRT2535478	hsa-miR-550a	CLIP-seq
MIRT2535479	hsa-miR-661	CLIP-seq
MIRT2535480	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005813	Component	Centrosome	IMP	12154070
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IEA
GO:0005874	Component	Microtubule	IMP	12154070, 12445389
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IMP	12154070
GO:0031122	Process	Cytoplasmic microtubule organization	IMP	12154070, 12445389
GO:0032154	Component	Cleavage furrow	IEA
GO:0032465	Process	Regulation of cytokinesis	IDA	12445389
GO:0042802	Function	Identical protein binding	IPI	12154070
GO:0051301	Process	Cell division	IEA
GO:0051302	Process	Regulation of cell division	IBA
GO:0051302	Process	Regulation of cell division	IDA	12445389
GO:0060236	Process	Regulation of mitotic spindle organization	IBA
GO:0060236	Process	Regulation of mitotic spindle organization	IDA	12154070

Other IDs

• MIM: 609828
• HGNC: 13745
• e!Ensembl: ENSG00000105255

Protein

• UniProt ID: Q9BTV5
• Protein name: Fibronectin type III and SPRY domain-containing protein 1 (MID1-related protein 1) (Microtubule-associated protein GLFND)
• Protein function: May be involved in microtubule organization and stabilization.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00041	fn3	167 → 258	Fibronectin type III domain	Domain
  PF00622	SPRY	355 → 473	SPRY domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in brain tissues, including cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Lower expression in spinal cord. {ECO:0000269|PubMed:11267680, ECO:0000269|PubMed:12154070}.
• Sequence:

  MEEQREALRKIIKTLAVKNEEIQSFIYSLKQMLLNVEANSAKVQEDLEAEFQSLFSLLEE
  LKEGMLMKIKQDRASRTYELQNQLAACTRALESSEELLETANQTLQAMDSEDFPQAAKQI
  KDGVTMAPAFRLSLKAKVSDNMSHLMVDFAQERQMLQALKFLPVPSAPVIDLAESLVADN
  CVTLVWRMPDEDSKIDHYVLEYRRTNFEGPPRLKEDQPWMVIEGIRQTEYTLTGLKFDMK
  YMNFRVKACNKAVAGEFSEPVTLETPAFMFRLDASTSHQNLRVDDLSVEWDAMGGKVQDI
  KAREKDGKGRTASPINSPARGTPSPKRMPSGRGGRDRFTAESYTVLGDTLIDGGEHYWEV
  RYEPDSKAFGVGVAYRSLGRFEQLGKTAASWCLHVNNWLQVSFTAKHANKVKVLDAPVPD
  CLGVHCDFHQGLLSFYNARTKQVLHTFKTRFTQPLLPAFTVWCGSFQVTTGLQVPSAVRC
  LQKRGSATSSSNTSLT

• Sequence length: 496

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