Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	79184
Gene name	BRCA1/BRCA2-containing complex subunit 3
Gene symbol	BRCC3
Synonyms (NCBI Gene)	BRCC36C6.1ACXorf53
Chromosome	X
Chromosome location	Xq28
Summary	This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component

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miRTarBase ID	miRNA	Experiments	Reference
MIRT049186	hsa-miR-92a-3p	CLASH	23622248
MIRT041195	hsa-miR-193b-3p	CLASH	23622248
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	21572407
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509212	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT509210	hsa-miR-567	HITS-CLIP	21572407
MIRT509209	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509206	hsa-miR-297	HITS-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	HITS-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	HITS-CLIP	21572407
MIRT509211	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT660164	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT660163	hsa-miR-596	HITS-CLIP	23824327
MIRT660162	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT660161	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT660160	hsa-miR-4269	HITS-CLIP	23824327
MIRT660159	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT660158	hsa-miR-4514	HITS-CLIP	23824327
MIRT660157	hsa-miR-4692	HITS-CLIP	23824327
MIRT660156	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT660155	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT660154	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT660153	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT660152	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT660151	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT660150	hsa-miR-7977	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509209	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT524738	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	PAR-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	PAR-CLIP	21572407
MIRT550785	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	PAR-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT524738	hsa-miR-3121-5p	PAR-CLIP	23446348
MIRT509212	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509209	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT509211	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT509212	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509211	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509209	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT445918	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT445917	hsa-miR-1264	PAR-CLIP	22100165
MIRT445916	hsa-miR-208a-5p	PAR-CLIP	22100165
MIRT445915	hsa-miR-208b-5p	PAR-CLIP	22100165
MIRT445914	hsa-miR-7705	PAR-CLIP	22100165
MIRT445913	hsa-miR-4635	PAR-CLIP	22100165
MIRT445912	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT445911	hsa-miR-573	PAR-CLIP	22100165
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	27418678
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	27418678
MIRT509209	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT509209	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	27418678
MIRT509212	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT509212	hsa-miR-511-3p	HITS-CLIP	27418678
MIRT509211	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT509211	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT509208	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT509208	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	21572407
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509212	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT509210	hsa-miR-567	HITS-CLIP	21572407
MIRT509209	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509206	hsa-miR-297	HITS-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	HITS-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	HITS-CLIP	21572407
MIRT509211	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT660164	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT660163	hsa-miR-596	HITS-CLIP	23824327
MIRT660162	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT660161	hsa-miR-4742-5p	HITS-CLIP	23824327
MIRT660160	hsa-miR-4269	HITS-CLIP	23824327
MIRT660159	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT660158	hsa-miR-4514	HITS-CLIP	23824327
MIRT660157	hsa-miR-4692	HITS-CLIP	23824327
MIRT660156	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT660155	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT660154	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT660153	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT660152	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT660151	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT660150	hsa-miR-7977	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT524738	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT509209	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT509207	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT550785	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT524738	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	PAR-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	PAR-CLIP	21572407
MIRT550785	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT541943	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509212	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509210	hsa-miR-567	PAR-CLIP	21572407
MIRT509209	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509206	hsa-miR-297	PAR-CLIP	21572407
MIRT541942	hsa-miR-4743-3p	PAR-CLIP	21572407
MIRT541941	hsa-miR-4652-3p	PAR-CLIP	21572407
MIRT509211	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT524738	hsa-miR-3121-5p	PAR-CLIP	23446348
MIRT509212	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509209	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT509211	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT509212	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509211	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT509210	hsa-miR-567	PAR-CLIP	23446348
MIRT509209	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509208	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT509207	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509206	hsa-miR-297	PAR-CLIP	23446348
MIRT445918	hsa-miR-3184-3p	PAR-CLIP	22100165
MIRT445917	hsa-miR-1264	PAR-CLIP	22100165
MIRT445916	hsa-miR-208a-5p	PAR-CLIP	22100165
MIRT445915	hsa-miR-208b-5p	PAR-CLIP	22100165
MIRT445914	hsa-miR-7705	PAR-CLIP	22100165
MIRT445913	hsa-miR-4635	PAR-CLIP	22100165
MIRT445912	hsa-miR-3616-5p	PAR-CLIP	22100165
MIRT445911	hsa-miR-573	PAR-CLIP	22100165
MIRT755767	hsa-miR-4796-5p	Luciferase reporter assayWestern blottingqRT-PCRin vitro cullelar assaysGFP reporter assay	37460775
MIRT824103	hsa-miR-181a	CLIP-seq
MIRT824104	hsa-miR-181b	CLIP-seq
MIRT824105	hsa-miR-181c	CLIP-seq
MIRT824106	hsa-miR-181d	CLIP-seq
MIRT824107	hsa-miR-3908	CLIP-seq
MIRT824108	hsa-miR-4262	CLIP-seq
MIRT824109	hsa-miR-4276	CLIP-seq
MIRT824110	hsa-miR-4307	CLIP-seq
MIRT824111	hsa-miR-4326	CLIP-seq
MIRT824112	hsa-miR-4421	CLIP-seq
MIRT824113	hsa-miR-4711-3p	CLIP-seq
MIRT824114	hsa-miR-4718	CLIP-seq
MIRT824115	hsa-miR-4727-5p	CLIP-seq
MIRT824116	hsa-miR-4769-3p	CLIP-seq
MIRT824117	hsa-miR-494	CLIP-seq
MIRT824118	hsa-miR-545	CLIP-seq
MIRT824119	hsa-miR-568	CLIP-seq
MIRT824120	hsa-miR-101	CLIP-seq
MIRT824121	hsa-miR-105	CLIP-seq
MIRT824122	hsa-miR-1243	CLIP-seq
MIRT824123	hsa-miR-144	CLIP-seq
MIRT824124	hsa-miR-145	CLIP-seq
MIRT824125	hsa-miR-21	CLIP-seq
MIRT824126	hsa-miR-218	CLIP-seq
MIRT824127	hsa-miR-3150a-5p	CLIP-seq
MIRT824128	hsa-miR-3150b-5p	CLIP-seq
MIRT824129	hsa-miR-3180-5p	CLIP-seq
MIRT824130	hsa-miR-3201	CLIP-seq
MIRT824131	hsa-miR-3672	CLIP-seq
MIRT824132	hsa-miR-3940-5p	CLIP-seq
MIRT824133	hsa-miR-410	CLIP-seq
MIRT824134	hsa-miR-4260	CLIP-seq
MIRT824135	hsa-miR-4283	CLIP-seq
MIRT824136	hsa-miR-4424	CLIP-seq
MIRT824137	hsa-miR-4463	CLIP-seq
MIRT824138	hsa-miR-4489	CLIP-seq
MIRT824139	hsa-miR-4501	CLIP-seq
MIRT824140	hsa-miR-4507	CLIP-seq
MIRT824141	hsa-miR-4720-3p	CLIP-seq
MIRT824142	hsa-miR-4789-5p	CLIP-seq
MIRT824143	hsa-miR-4791	CLIP-seq
MIRT824144	hsa-miR-4804-3p	CLIP-seq
MIRT824145	hsa-miR-485-3p	CLIP-seq
MIRT824146	hsa-miR-487a	CLIP-seq
MIRT824147	hsa-miR-513a-3p	CLIP-seq
MIRT824148	hsa-miR-590-3p	CLIP-seq
MIRT824149	hsa-miR-590-5p	CLIP-seq
MIRT824150	hsa-miR-591	CLIP-seq
MIRT824151	hsa-miR-636	CLIP-seq
MIRT1943622	hsa-miR-1	CLIP-seq
MIRT1943623	hsa-miR-1299	CLIP-seq
MIRT1943624	hsa-miR-136	CLIP-seq
MIRT1943625	hsa-miR-193a-5p	CLIP-seq
MIRT1943626	hsa-miR-206	CLIP-seq
MIRT1943627	hsa-miR-219-2-3p	CLIP-seq
MIRT1943628	hsa-miR-2964a-3p	CLIP-seq
MIRT1943629	hsa-miR-302f	CLIP-seq
MIRT1943630	hsa-miR-3140-3p	CLIP-seq
MIRT1943631	hsa-miR-323b-3p	CLIP-seq
MIRT1943632	hsa-miR-326	CLIP-seq
MIRT1943633	hsa-miR-330-5p	CLIP-seq
MIRT1943634	hsa-miR-3673	CLIP-seq
MIRT1943635	hsa-miR-383	CLIP-seq
MIRT824110	hsa-miR-4307	CLIP-seq
MIRT824111	hsa-miR-4326	CLIP-seq
MIRT1943636	hsa-miR-4452	CLIP-seq
MIRT1943637	hsa-miR-4464	CLIP-seq
MIRT1943638	hsa-miR-4641	CLIP-seq
MIRT1943639	hsa-miR-4691-5p	CLIP-seq
MIRT824113	hsa-miR-4711-3p	CLIP-seq
MIRT824115	hsa-miR-4727-5p	CLIP-seq
MIRT1943640	hsa-miR-4731-5p	CLIP-seq
MIRT1943641	hsa-miR-4748	CLIP-seq
MIRT1943642	hsa-miR-4768-5p	CLIP-seq
MIRT824116	hsa-miR-4769-3p	CLIP-seq
MIRT1943643	hsa-miR-4772-5p	CLIP-seq
MIRT1943644	hsa-miR-5096	CLIP-seq
MIRT1943645	hsa-miR-511	CLIP-seq
MIRT1943646	hsa-miR-520d-5p	CLIP-seq
MIRT1943647	hsa-miR-524-5p	CLIP-seq
MIRT1943648	hsa-miR-579	CLIP-seq
MIRT1943649	hsa-miR-613	CLIP-seq
MIRT1943650	hsa-miR-664	CLIP-seq
MIRT1943651	hsa-miR-875-3p	CLIP-seq
MIRT2182295	hsa-miR-1238	CLIP-seq
MIRT824124	hsa-miR-145	CLIP-seq
MIRT2182296	hsa-miR-1976	CLIP-seq
MIRT2182297	hsa-miR-3124-3p	CLIP-seq
MIRT824129	hsa-miR-3180-5p	CLIP-seq
MIRT2182298	hsa-miR-3650	CLIP-seq
MIRT2182299	hsa-miR-369-3p	CLIP-seq
MIRT2182300	hsa-miR-371-5p	CLIP-seq
MIRT824134	hsa-miR-4260	CLIP-seq
MIRT824135	hsa-miR-4283	CLIP-seq
MIRT824138	hsa-miR-4489	CLIP-seq
MIRT2182301	hsa-miR-4760-3p	CLIP-seq
MIRT1943642	hsa-miR-4768-5p	CLIP-seq
MIRT1943646	hsa-miR-520d-5p	CLIP-seq
MIRT1943647	hsa-miR-524-5p	CLIP-seq
MIRT2182302	hsa-miR-3115	CLIP-seq
MIRT2384870	hsa-miR-323-5p	CLIP-seq
MIRT2182298	hsa-miR-3650	CLIP-seq
MIRT2384871	hsa-miR-876-3p	CLIP-seq
MIRT824134	hsa-miR-4260	CLIP-seq
MIRT824135	hsa-miR-4283	CLIP-seq
MIRT824138	hsa-miR-4489	CLIP-seq
MIRT1943646	hsa-miR-520d-5p	CLIP-seq
MIRT1943647	hsa-miR-524-5p	CLIP-seq
MIRT2485948	hsa-let-7a	CLIP-seq
MIRT2485949	hsa-let-7b	CLIP-seq
MIRT2485950	hsa-let-7c	CLIP-seq
MIRT2485951	hsa-let-7d	CLIP-seq
MIRT2485952	hsa-let-7e	CLIP-seq
MIRT2485953	hsa-let-7f	CLIP-seq
MIRT2485954	hsa-let-7g	CLIP-seq
MIRT2485955	hsa-let-7i	CLIP-seq
MIRT2485956	hsa-miR-125a-5p	CLIP-seq
MIRT2485957	hsa-miR-125b	CLIP-seq
MIRT2485958	hsa-miR-1294	CLIP-seq
MIRT2485959	hsa-miR-129-5p	CLIP-seq
MIRT2485960	hsa-miR-1305	CLIP-seq
MIRT2485961	hsa-miR-1914	CLIP-seq
MIRT2485962	hsa-miR-197	CLIP-seq
MIRT2182296	hsa-miR-1976	CLIP-seq
MIRT2485963	hsa-miR-202	CLIP-seq
MIRT2485964	hsa-miR-23a	CLIP-seq
MIRT2485965	hsa-miR-23b	CLIP-seq
MIRT2485966	hsa-miR-23c	CLIP-seq
MIRT2485967	hsa-miR-3119	CLIP-seq
MIRT2485968	hsa-miR-3140-5p	CLIP-seq
MIRT824131	hsa-miR-3672	CLIP-seq
MIRT2485969	hsa-miR-3674	CLIP-seq
MIRT2182299	hsa-miR-369-3p	CLIP-seq
MIRT2485970	hsa-miR-375	CLIP-seq
MIRT2485971	hsa-miR-3924	CLIP-seq
MIRT2485972	hsa-miR-3973	CLIP-seq
MIRT824133	hsa-miR-410	CLIP-seq
MIRT2485973	hsa-miR-421	CLIP-seq
MIRT2485974	hsa-miR-4263	CLIP-seq
MIRT2485975	hsa-miR-4279	CLIP-seq
MIRT2485976	hsa-miR-4316	CLIP-seq
MIRT2485977	hsa-miR-4319	CLIP-seq
MIRT824136	hsa-miR-4424	CLIP-seq
MIRT2485978	hsa-miR-4426	CLIP-seq
MIRT2485979	hsa-miR-4458	CLIP-seq
MIRT824137	hsa-miR-4463	CLIP-seq
MIRT2485980	hsa-miR-4474-3p	CLIP-seq
MIRT2485981	hsa-miR-4500	CLIP-seq
MIRT1943638	hsa-miR-4641	CLIP-seq
MIRT2485982	hsa-miR-4647	CLIP-seq
MIRT2485983	hsa-miR-4662b	CLIP-seq
MIRT2485984	hsa-miR-4699-5p	CLIP-seq
MIRT2485985	hsa-miR-4709-5p	CLIP-seq
MIRT2485986	hsa-miR-4732-5p	CLIP-seq
MIRT2485987	hsa-miR-4735-5p	CLIP-seq
MIRT824142	hsa-miR-4789-5p	CLIP-seq
MIRT824145	hsa-miR-485-3p	CLIP-seq
MIRT824146	hsa-miR-487a	CLIP-seq
MIRT824117	hsa-miR-494	CLIP-seq
MIRT1943645	hsa-miR-511	CLIP-seq
MIRT824147	hsa-miR-513a-3p	CLIP-seq
MIRT2485988	hsa-miR-520g	CLIP-seq
MIRT2485989	hsa-miR-520h	CLIP-seq
MIRT2485990	hsa-miR-544b	CLIP-seq
MIRT2485991	hsa-miR-548ae	CLIP-seq
MIRT2485992	hsa-miR-548aj	CLIP-seq
MIRT2485993	hsa-miR-548am	CLIP-seq
MIRT2485994	hsa-miR-548x	CLIP-seq
MIRT2485995	hsa-miR-576-3p	CLIP-seq
MIRT2485996	hsa-miR-576-5p	CLIP-seq
MIRT2485997	hsa-miR-578	CLIP-seq
MIRT824148	hsa-miR-590-3p	CLIP-seq
MIRT2485998	hsa-miR-607	CLIP-seq
MIRT2485999	hsa-miR-643	CLIP-seq
MIRT1943650	hsa-miR-664	CLIP-seq
MIRT2486000	hsa-miR-98	CLIP-seq
MIRT2485948	hsa-let-7a	CLIP-seq
MIRT2485949	hsa-let-7b	CLIP-seq
MIRT2485950	hsa-let-7c	CLIP-seq
MIRT2485951	hsa-let-7d	CLIP-seq
MIRT2485952	hsa-let-7e	CLIP-seq
MIRT2485953	hsa-let-7f	CLIP-seq
MIRT2485954	hsa-let-7g	CLIP-seq
MIRT2485955	hsa-let-7i	CLIP-seq
MIRT2485956	hsa-miR-125a-5p	CLIP-seq
MIRT2485957	hsa-miR-125b	CLIP-seq
MIRT2485959	hsa-miR-129-5p	CLIP-seq
MIRT2485960	hsa-miR-1305	CLIP-seq
MIRT2485961	hsa-miR-1914	CLIP-seq
MIRT2485962	hsa-miR-197	CLIP-seq
MIRT2182296	hsa-miR-1976	CLIP-seq
MIRT2485963	hsa-miR-202	CLIP-seq
MIRT2485964	hsa-miR-23a	CLIP-seq
MIRT2485965	hsa-miR-23b	CLIP-seq
MIRT2485966	hsa-miR-23c	CLIP-seq
MIRT2485967	hsa-miR-3119	CLIP-seq
MIRT2485968	hsa-miR-3140-5p	CLIP-seq
MIRT824131	hsa-miR-3672	CLIP-seq
MIRT2485969	hsa-miR-3674	CLIP-seq
MIRT2182299	hsa-miR-369-3p	CLIP-seq
MIRT2485970	hsa-miR-375	CLIP-seq
MIRT2485971	hsa-miR-3924	CLIP-seq
MIRT2485972	hsa-miR-3973	CLIP-seq
MIRT824133	hsa-miR-410	CLIP-seq
MIRT2485975	hsa-miR-4279	CLIP-seq
MIRT2485977	hsa-miR-4319	CLIP-seq
MIRT824136	hsa-miR-4424	CLIP-seq
MIRT2485978	hsa-miR-4426	CLIP-seq
MIRT2485979	hsa-miR-4458	CLIP-seq
MIRT824137	hsa-miR-4463	CLIP-seq
MIRT2485980	hsa-miR-4474-3p	CLIP-seq
MIRT2485981	hsa-miR-4500	CLIP-seq
MIRT2485982	hsa-miR-4647	CLIP-seq
MIRT2485983	hsa-miR-4662b	CLIP-seq
MIRT2485984	hsa-miR-4699-5p	CLIP-seq
MIRT2485986	hsa-miR-4732-5p	CLIP-seq
MIRT824142	hsa-miR-4789-5p	CLIP-seq
MIRT824117	hsa-miR-494	CLIP-seq
MIRT1943645	hsa-miR-511	CLIP-seq
MIRT824147	hsa-miR-513a-3p	CLIP-seq
MIRT2485988	hsa-miR-520g	CLIP-seq
MIRT2485989	hsa-miR-520h	CLIP-seq
MIRT2485990	hsa-miR-544b	CLIP-seq
MIRT2485991	hsa-miR-548ae	CLIP-seq
MIRT2485992	hsa-miR-548aj	CLIP-seq
MIRT2485993	hsa-miR-548am	CLIP-seq
MIRT2485994	hsa-miR-548x	CLIP-seq
MIRT2485995	hsa-miR-576-3p	CLIP-seq
MIRT2485997	hsa-miR-578	CLIP-seq
MIRT824148	hsa-miR-590-3p	CLIP-seq
MIRT2485998	hsa-miR-607	CLIP-seq
MIRT1943650	hsa-miR-664	CLIP-seq
MIRT2486000	hsa-miR-98	CLIP-seq

Show/Hide all (57)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IDA	14636569
GO:0000152	Component	Nuclear ubiquitin ligase complex	IDA	14636569
GO:0000922	Component	Spindle pole	IEA
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0005515	Function	Protein binding	IPI	14636569, 18077395, 19202061, 19261748, 19261749, 19615732, 32296183, 33961781, 37398436
GO:0005634	Component	Nucleus	IDA	14636569, 19202061
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	20656689
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	24075985
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006282	Process	Regulation of DNA repair	NAS	20656689
GO:0006302	Process	Double-strand break repair	IBA
GO:0006302	Process	Double-strand break repair	IMP	17525341, 19261746, 19261748
GO:0006325	Process	Chromatin organization	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0006974	Process	DNA damage response	IEA
GO:0007095	Process	Mitotic G2 DNA damage checkpoint signaling	IMP	17525341, 19261746, 19261748
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IBA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IMP	17525341, 19214193, 19261746
GO:0010165	Process	Response to X-ray	IDA	14636569
GO:0010212	Process	Response to ionizing radiation	IMP	17525341, 19261746, 19261748
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0030234	Function	Enzyme regulator activity	IDA	14636569
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IBA
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IDA	19261749
GO:0044546	Process	NLRP3 inflammasome complex assembly	IDA	35114687, 35254907
GO:0044818	Process	Mitotic G2/M transition checkpoint	NAS	22369660
GO:0045739	Process	Positive regulation of DNA repair	IMP	17525341, 19261746, 19261748
GO:0046872	Function	Metal ion binding	IEA
GO:0051301	Process	Cell division	IEA
GO:0061578	Function	K63-linked deubiquitinase activity	IDA	19202061, 28943315
GO:0061578	Function	K63-linked deubiquitinase activity	TAS
GO:0070531	Component	BRCA1-A complex	IBA
GO:0070531	Component	BRCA1-A complex	IDA	17525341, 19202061, 19261746, 19261748, 19261749
GO:0070531	Component	BRCA1-A complex	IEA
GO:0070531	Component	BRCA1-A complex	NAS	20656689
GO:0070536	Process	Protein K63-linked deubiquitination	IDA	17525341, 19214193
GO:0070536	Process	Protein K63-linked deubiquitination	IEA
GO:0070536	Process	Protein K63-linked deubiquitination	IMP	24075985
GO:0070552	Component	BRISC complex	IBA
GO:0070552	Component	BRISC complex	IDA	19214193, 24075985
GO:0070552	Component	BRISC complex	IEA
GO:0071479	Process	Cellular response to ionizing radiation	IMP	14636569
GO:0140492	Function	Metal-dependent deubiquitinase activity	IEA
GO:0140492	Function	Metal-dependent deubiquitinase activity	IMP	19261746
GO:0140861	Process	DNA repair-dependent chromatin remodeling	IMP	19202061, 19261746
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	IDA	28943315
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	ISS
GO:2000001	Process	Regulation of DNA damage checkpoint	NAS	14636569

MIM	HGNC	e!Ensembl
300617	24185	ENSG00000185515

P46736

Protein name

Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)

Protein function

Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains (PubMed:19214193, PubMed:2065

PDB

6H3C , 6R8F , 8PVY , 8PY2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01398	JAB	7 → 148	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	Family
PF18110	BRCC36_C	228 → 308	BRCC36 C-terminal helical domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Aberrantly expressed in the vast majority of breast tumors. {ECO:0000269|PubMed:16707425}.

Sequence

MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMR
TVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGW
YHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQK
SSESLHGPRDFWSSSQHISIEGQKEEERYERIEIPIHIVPHVTIGKVCLESAVELPKILC
QEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQE
LQQEKEELMQELSSLE

Sequence length

316

Interactions

View interactions

	KEGG		Reactome
	Homologous recombination NOD-like receptor signaling pathway		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Hereditary cancer-predisposing syndrome	Likely benign	rs184669955, rs782283086, rs869312527, rs376342905, rs869312528, rs869312529, rs869312530, rs190280980	RCV000209191 RCV000209521 RCV000208901 RCV000209349 RCV000209556 RCV000208939 RCV000209266 RCV000209682

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	14636569, 26024915, 34309165
Inflammation	Associate	37681916
Inflammatory Bowel Diseases	Associate	37681916
Leiomyoma	Associate	21685710
Moyamoya Disease	Associate	25093848
Nasopharyngeal Carcinoma	Associate	26024915
Neoplasms	Inhibit	26848770, 37887275
Neoplasms	Associate	31253574
Niemann Pick Disease Type C	Associate	26024915
Oncogene Addiction	Associate	17167184
Testicular Germ Cell Tumor	Associate	17167184
Triple Negative Breast Neoplasms	Associate	26848770
Uterine Cervical Neoplasms	Stimulate	30272359

BRCC3 (BRCA1/BRCA2-containing complex subunit 3)