Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	79023
Gene name Gene Name - the full gene name approved by the HGNC.	Nucleoporin 37
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NUP37
Synonyms (NCBI Gene) Gene synonyms aliases	MCPH24, p37
Disease Acronyms (UniProt) Disease acronyms from UniProt database	MCPH24
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q23.2
Summary Summary of gene provided in NCBI Entrez Gene.	Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein enc

Show/Hide all(2)

SNP ID	Visualize variation	Clinical significance	Consequence
rs746341112	G>A	Likely-pathogenic	Coding sequence variant, stop gained, non coding transcript variant
rs1309880692	->A	Pathogenic	Coding sequence variant, stop gained, non coding transcript variant

Show/Hide all(216)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047580	hsa-miR-10a-5p	CLASH	23622248
MIRT041410	hsa-miR-193b-3p	CLASH	23622248
MIRT549734	hsa-miR-548c-3p	HITS-CLIP	21572407
MIRT549733	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT549732	hsa-miR-8485	HITS-CLIP	21572407
MIRT549731	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT549730	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT549728	hsa-miR-603	HITS-CLIP	21572407
MIRT707105	hsa-miR-4773	HITS-CLIP	21572407
MIRT549729	hsa-miR-3925-5p	HITS-CLIP	21572407
MIRT549727	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT549726	hsa-miR-3919	HITS-CLIP	21572407
MIRT549725	hsa-miR-3941	HITS-CLIP	21572407
MIRT549724	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT549723	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT568717	hsa-miR-5582-3p	PAR-CLIP	20371350
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT535575	hsa-miR-4324	PAR-CLIP	20371350
MIRT535574	hsa-miR-544b	PAR-CLIP	20371350
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT535573	hsa-miR-1200	PAR-CLIP	20371350
MIRT535571	hsa-miR-3915	PAR-CLIP	20371350
MIRT568717	hsa-miR-5582-3p	PAR-CLIP	20371350
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT535575	hsa-miR-4324	PAR-CLIP	20371350
MIRT535574	hsa-miR-544b	PAR-CLIP	20371350
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT535573	hsa-miR-1200	PAR-CLIP	20371350
MIRT535571	hsa-miR-3915	PAR-CLIP	20371350
MIRT568717	hsa-miR-5582-3p	PAR-CLIP	20371350
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT535575	hsa-miR-4324	PAR-CLIP	20371350
MIRT535574	hsa-miR-544b	PAR-CLIP	20371350
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT535573	hsa-miR-1200	PAR-CLIP	20371350
MIRT535571	hsa-miR-3915	PAR-CLIP	20371350
MIRT549722	hsa-miR-345-3p	PAR-CLIP	20371350
MIRT549721	hsa-miR-4732-3p	PAR-CLIP	20371350
MIRT549720	hsa-miR-125a-5p	PAR-CLIP	20371350
MIRT549719	hsa-miR-125b-5p	PAR-CLIP	20371350
MIRT549718	hsa-miR-4319	PAR-CLIP	20371350
MIRT535575	hsa-miR-4324	PAR-CLIP	20371350
MIRT549716	hsa-miR-4251	PAR-CLIP	20371350
MIRT549715	hsa-miR-3657	PAR-CLIP	20371350
MIRT549714	hsa-miR-4669	PAR-CLIP	20371350
MIRT549713	hsa-miR-670-5p	PAR-CLIP	20371350
MIRT549711	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT549734	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT549733	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT549732	hsa-miR-8485	PAR-CLIP	21572407
MIRT549731	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT549730	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT549728	hsa-miR-603	PAR-CLIP	21572407
MIRT549729	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT549727	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT549726	hsa-miR-3919	PAR-CLIP	21572407
MIRT549725	hsa-miR-3941	PAR-CLIP	21572407
MIRT549724	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT549723	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT549722	hsa-miR-345-3p	PAR-CLIP	21572407
MIRT549721	hsa-miR-4732-3p	PAR-CLIP	21572407
MIRT549720	hsa-miR-125a-5p	PAR-CLIP	21572407
MIRT549719	hsa-miR-125b-5p	PAR-CLIP	21572407
MIRT549718	hsa-miR-4319	PAR-CLIP	21572407
MIRT535575	hsa-miR-4324	PAR-CLIP	21572407
MIRT549717	hsa-miR-130b-5p	PAR-CLIP	21572407
MIRT549716	hsa-miR-4251	PAR-CLIP	21572407
MIRT549715	hsa-miR-3657	PAR-CLIP	21572407
MIRT549714	hsa-miR-4669	PAR-CLIP	21572407
MIRT549713	hsa-miR-670-5p	PAR-CLIP	21572407
MIRT549712	hsa-miR-4753-3p	PAR-CLIP	21572407
MIRT549711	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT549710	hsa-miR-3161	PAR-CLIP	21572407
MIRT549709	hsa-miR-4768-5p	PAR-CLIP	21572407
MIRT549708	hsa-miR-6833-3p	PAR-CLIP	21572407
MIRT549707	hsa-miR-6809-3p	PAR-CLIP	21572407
MIRT549706	hsa-miR-6832-3p	PAR-CLIP	21572407
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	22012620
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	22012620
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	22012620
MIRT535575	hsa-miR-4324	PAR-CLIP	22012620
MIRT535574	hsa-miR-544b	PAR-CLIP	22012620
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	22012620
MIRT535573	hsa-miR-1200	PAR-CLIP	22012620
MIRT535571	hsa-miR-3915	PAR-CLIP	22012620
MIRT535573	hsa-miR-1200	PAR-CLIP	27292025
MIRT535573	hsa-miR-1200	PAR-CLIP	27292025
MIRT535573	hsa-miR-1200	PAR-CLIP	27292025
MIRT535573	hsa-miR-1200	PAR-CLIP	27292025
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	27292025
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	27292025
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	27292025
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	27292025
MIRT535571	hsa-miR-3915	PAR-CLIP	27292025
MIRT535571	hsa-miR-3915	PAR-CLIP	27292025
MIRT535571	hsa-miR-3915	PAR-CLIP	27292025
MIRT535571	hsa-miR-3915	PAR-CLIP	27292025
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	27292025
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	27292025
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	27292025
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	27292025
MIRT535575	hsa-miR-4324	PAR-CLIP	27292025
MIRT535575	hsa-miR-4324	PAR-CLIP	27292025
MIRT535575	hsa-miR-4324	PAR-CLIP	27292025
MIRT535575	hsa-miR-4324	PAR-CLIP	27292025
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	27292025
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	27292025
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	27292025
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	27292025
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	27292025
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	27292025
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	27292025
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	27292025
MIRT535574	hsa-miR-544b	PAR-CLIP	27292025
MIRT535574	hsa-miR-544b	PAR-CLIP	27292025
MIRT535574	hsa-miR-544b	PAR-CLIP	27292025
MIRT535574	hsa-miR-544b	PAR-CLIP	27292025
MIRT568717	hsa-miR-5582-3p	PAR-CLIP	27292025
MIRT568717	hsa-miR-5582-3p	PAR-CLIP	27292025
MIRT568717	hsa-miR-5582-3p	PAR-CLIP	27292025
MIRT568717	hsa-miR-5582-3p	PAR-CLIP	27292025
MIRT549734	hsa-miR-548c-3p	HITS-CLIP	21572407
MIRT549733	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT549732	hsa-miR-8485	HITS-CLIP	21572407
MIRT549731	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT549730	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT549728	hsa-miR-603	HITS-CLIP	21572407
MIRT707105	hsa-miR-4773	HITS-CLIP	21572407
MIRT549729	hsa-miR-3925-5p	HITS-CLIP	21572407
MIRT549727	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT549726	hsa-miR-3919	HITS-CLIP	21572407
MIRT549725	hsa-miR-3941	HITS-CLIP	21572407
MIRT549724	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT549723	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT568717	hsa-miR-5582-3p	PAR-CLIP	20371350
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT535575	hsa-miR-4324	PAR-CLIP	20371350
MIRT535574	hsa-miR-544b	PAR-CLIP	20371350
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT535573	hsa-miR-1200	PAR-CLIP	20371350
MIRT535571	hsa-miR-3915	PAR-CLIP	20371350
MIRT568717	hsa-miR-5582-3p	PAR-CLIP	20371350
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT535575	hsa-miR-4324	PAR-CLIP	20371350
MIRT535574	hsa-miR-544b	PAR-CLIP	20371350
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT535573	hsa-miR-1200	PAR-CLIP	20371350
MIRT535571	hsa-miR-3915	PAR-CLIP	20371350
MIRT568717	hsa-miR-5582-3p	PAR-CLIP	20371350
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT535575	hsa-miR-4324	PAR-CLIP	20371350
MIRT535574	hsa-miR-544b	PAR-CLIP	20371350
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT535573	hsa-miR-1200	PAR-CLIP	20371350
MIRT535571	hsa-miR-3915	PAR-CLIP	20371350
MIRT549722	hsa-miR-345-3p	PAR-CLIP	20371350
MIRT549721	hsa-miR-4732-3p	PAR-CLIP	20371350
MIRT549720	hsa-miR-125a-5p	PAR-CLIP	20371350
MIRT549719	hsa-miR-125b-5p	PAR-CLIP	20371350
MIRT549718	hsa-miR-4319	PAR-CLIP	20371350
MIRT535575	hsa-miR-4324	PAR-CLIP	20371350
MIRT549716	hsa-miR-4251	PAR-CLIP	20371350
MIRT549715	hsa-miR-3657	PAR-CLIP	20371350
MIRT549714	hsa-miR-4669	PAR-CLIP	20371350
MIRT549713	hsa-miR-670-5p	PAR-CLIP	20371350
MIRT549711	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT549734	hsa-miR-548c-3p	PAR-CLIP	21572407
MIRT549733	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT549732	hsa-miR-8485	PAR-CLIP	21572407
MIRT549731	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT549730	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT549728	hsa-miR-603	PAR-CLIP	21572407
MIRT549729	hsa-miR-3925-5p	PAR-CLIP	21572407
MIRT549727	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT549726	hsa-miR-3919	PAR-CLIP	21572407
MIRT549725	hsa-miR-3941	PAR-CLIP	21572407
MIRT549724	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT549723	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT549722	hsa-miR-345-3p	PAR-CLIP	21572407
MIRT549721	hsa-miR-4732-3p	PAR-CLIP	21572407
MIRT549720	hsa-miR-125a-5p	PAR-CLIP	21572407
MIRT549719	hsa-miR-125b-5p	PAR-CLIP	21572407
MIRT549718	hsa-miR-4319	PAR-CLIP	21572407
MIRT535575	hsa-miR-4324	PAR-CLIP	21572407
MIRT549717	hsa-miR-130b-5p	PAR-CLIP	21572407
MIRT549716	hsa-miR-4251	PAR-CLIP	21572407
MIRT549715	hsa-miR-3657	PAR-CLIP	21572407
MIRT549714	hsa-miR-4669	PAR-CLIP	21572407
MIRT549713	hsa-miR-670-5p	PAR-CLIP	21572407
MIRT549712	hsa-miR-4753-3p	PAR-CLIP	21572407
MIRT549711	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT549710	hsa-miR-3161	PAR-CLIP	21572407
MIRT549709	hsa-miR-4768-5p	PAR-CLIP	21572407
MIRT549708	hsa-miR-6833-3p	PAR-CLIP	21572407
MIRT549707	hsa-miR-6809-3p	PAR-CLIP	21572407
MIRT549706	hsa-miR-6832-3p	PAR-CLIP	21572407
MIRT535578	hsa-miR-3606-3p	PAR-CLIP	22012620
MIRT535577	hsa-miR-513a-3p	PAR-CLIP	22012620
MIRT535576	hsa-miR-513c-3p	PAR-CLIP	22012620
MIRT535575	hsa-miR-4324	PAR-CLIP	22012620
MIRT535574	hsa-miR-544b	PAR-CLIP	22012620
MIRT535572	hsa-miR-3928-3p	PAR-CLIP	22012620
MIRT535573	hsa-miR-1200	PAR-CLIP	22012620
MIRT535571	hsa-miR-3915	PAR-CLIP	22012620

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000776	Component	Kinetochore	IDA	15146057
GO:0000777	Component	Condensed chromosome kinetochore	IEA
GO:0005515	Function	Protein binding	IPI	15146057, 24981860, 27194810, 28514442, 32814053
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005635	Component	Nuclear envelope	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006110	Process	Regulation of glycolytic process	TAS
GO:0006406	Process	MRNA export from nucleus	TAS
GO:0006409	Process	TRNA export from nucleus	TAS
GO:0007049	Process	Cell cycle	IEA
GO:0007059	Process	Chromosome segregation	IEA
GO:0016032	Process	Viral process	TAS
GO:0016925	Process	Protein sumoylation	TAS
GO:0019083	Process	Viral transcription	TAS
GO:0031080	Component	Nuclear pore outer ring	IBA	21873635
GO:0031080	Component	Nuclear pore outer ring	IDA	15146057, 17360435
GO:0031080	Component	Nuclear pore outer ring	NAS	17363900
GO:0043657	Component	Host cell	IEA
GO:0051301	Process	Cell division	IEA
GO:0060964	Process	Regulation of gene silencing by miRNA	TAS
GO:0075733	Process	Intracellular transport of virus	TAS
GO:1900034	Process	Regulation of cellular response to heat	TAS

MIM	HGNC	e!Ensembl
609264	29929	ENSG00000075188

Protein

UniProt ID

Q8NFH4

Protein name

Nucleoporin Nup37 (p37) (Nup107-160 subcomplex subunit Nup37)

Protein function

Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitot

PDB

5A9Q , 7PEQ , 7R5J , 7R5K

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	114 → 153	WD domain, G-beta repeat	Repeat

Sequence

MKQDASRNAAYTVDCEDYVHVVEFNPFENGDSGNLIAYGGNNYVVIGTCTFQEEEADVEG
IQYKTLRTFHHGVRVDGIAWSPETRLDSLPPVIKFCTSAADMKIRLFTSDLQDKNEYKVL
EGHTDFINGLVFDPKEGQEIASVSDDHTCRIWNLEGVQTAHFVLHSPGMSVCWHPEETFK
LMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDITRS
SYPQNKRPVHMDRACLFRWSTISENLFATTGYPGKMASQFQIHHLGHPQPILMGSVAVGS
GLSWHRTLPLCVIGGDHKLLFWVTEV

Sequence length

326

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport Amyotrophic lateral sclerosis		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Microcephaly	Microcephaly, MICROCEPHALY 24, PRIMARY, AUTOSOMAL RECESSIVE	rs397704721, rs267607176, rs267607177, rs397704725, rs267606717, rs267606718, rs199422202, rs121434311, rs199422203, rs199422126, rs387906274, rs121434305, rs199422125, rs199422135, rs189678019 View all (280 more)	30179222
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Nephrotic syndrome	Nephrotic Syndrome	rs876657369, rs121912601, rs121912602, rs876657370, rs121912603, rs121912604, rs121912605, rs121907900, rs121907901, rs28941778, rs587776576, rs28942089, rs587776577, rs28941777, rs121907910 View all (152 more)	30179222

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Nephrotic Syndrome	familial idiopathic steroid-resistant nephrotic syndrome			GenCC

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinogenesis	Associate	14562370
Carcinoma Hepatocellular	Associate	31881970, 35093119
Glioma	Associate	34264013, 35093934
Lyme Disease	Associate	9986810
Mouth Neoplasms	Associate	36052378
Neoplasm Metastasis	Associate	28036384
Neoplasms	Associate	14562370, 24007313, 34264013, 35093934, 36052378
Neoplasms	Stimulate	28036384
Precancerous Conditions	Associate	34264013
Prostatic Neoplasms	Associate	21663671
Squamous Cell Carcinoma of Head and Neck	Associate	24007313
Stomach Neoplasms	Associate	14562370

NUP37 (nucleoporin 37)