PXDN (peroxidasin)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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7837 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Peroxidasin |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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PXDN |
Synonyms (NCBI Gene)
Gene synonyms aliases
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ASGD7, COPOA, D2S448, D2S448E, MG50, PRG2, PXN, VPO, hsPxd01 |
Disease Acronyms (UniProt)
Disease acronyms from UniProt database
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ASGD7 |
Chromosome
Chromosome number
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2 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2p25.3 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in th |
SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||||||||||||||||||||||||||||||||||||||||||
UniProt ID | Q92626 | ||||||||||||||||||||||||||||||||||||||||||||||||||
Protein name | Peroxidasin homolog (EC 1.11.2.-) (Melanoma-associated antigen MG50) (Peroxidasin 1) (hsPxd01) (Vascular peroxidase 1) (p53-responsive gene 2 protein) [Cleaved into: PXDN active fragment] | ||||||||||||||||||||||||||||||||||||||||||||||||||
Protein function | Catalyzes the two-electron oxidation of bromide by hydrogen peroxide and generates hypobromite as a reactive intermediate which mediates the formation of sulfilimine cross-links between methionine and hydroxylysine residues within an uncross-lin | ||||||||||||||||||||||||||||||||||||||||||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Expressed at higher levels in heart, lung, ovary, spleen, intestine and placenta, and at lower levels in liver, colon, pancreas, kidney, thymus, skeletal muscle and prostate. Expressed in tumors such as melanoma, breast cancer, ovarian | ||||||||||||||||||||||||||||||||||||||||||||||||||
Sequence | |||||||||||||||||||||||||||||||||||||||||||||||||||
Sequence length | 1479 | ||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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