Gene Gene information from NCBI Gene database.
Entrez ID 7813
Gene name Ecotropic viral integration site 5
Gene symbol EVI5
Synonyms (NCBI Gene)
EVI-5NB4S
Chromosome 1
Chromosome location 1p22.1
miRNA miRNA information provided by mirtarbase database.
701
miRTarBase ID miRNA Experiments Reference
MIRT022914 hsa-miR-124-3p Microarray 18668037
MIRT027925 hsa-miR-96-5p Sequencing 20371350
MIRT047210 hsa-miR-182-5p CLASH 23622248
MIRT523844 hsa-miR-493-5p HITS-CLIP 21572407
MIRT523841 hsa-miR-5580-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0005096 Function GTPase activator activity IBA
GO:0005096 Function GTPase activator activity IDA 17562788
GO:0005096 Function GTPase activator activity IEA
GO:0005515 Function Protein binding IPI 16439210, 17229837, 26496610, 30126976, 32296183, 33961781, 35271311
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602942 3501 ENSG00000067208
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60447
Protein name Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein)
Protein function Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00566 RabGAP-TBC 166 368 Rab-GTPase-TBC domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal. {ECO:0000269|PubMed:16033705, ECO:0000269|PubMed:9618176}.
Sequence
MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS
SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS
SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ
SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE
VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE
HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL
QMNQAELM
QLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT
KEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQARLSEAESQCA
LKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQ
RHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNH
LRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAA
VAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQP
PFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESET
EDSVLETRESNQVVQKERPPRRRESYSTTV
Sequence length 810
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
EVI5-related disorder Uncertain significance rs200507358 RCV000626006
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 25537516
Chromosome Deletion Inhibit 27909306
Multiple Myeloma Associate 27909306
Multiple Sclerosis Associate 19865102, 20087403, 24130709, 26433934, 32355262
Neoplasm Metastasis Associate 25537516
Neoplasms Associate 25537516