Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7804
Gene name Gene Name - the full gene name approved by the HGNC.	LDL receptor related protein 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LRP8
Synonyms (NCBI Gene) Gene synonyms aliases	APOER2, HSZ75190, LRP-8, MCI1
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p32.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal d

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs5174	C>T	Risk-factor	Genic downstream transcript variant, coding sequence variant, missense variant

Show/Hide all(607)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020152	hsa-miR-130b-3p	Sequencing	20371350
MIRT024366	hsa-miR-215-5p	Microarray	19074876
MIRT026507	hsa-miR-192-5p	Microarray	19074876
MIRT031127	hsa-miR-19b-3p	Sequencing	20371350
MIRT046111	hsa-miR-30b-5p	CLASH	23622248
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT656638	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT140086	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT522734	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT522733	hsa-miR-3119	PAR-CLIP	23446348
MIRT522732	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT440313	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT440313	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT656638	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT140086	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT611473	hsa-miR-8485	HITS-CLIP	23824327
MIRT611472	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT611471	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT611470	hsa-miR-603	HITS-CLIP	23824327
MIRT522734	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT522733	hsa-miR-3119	HITS-CLIP	23824327
MIRT611469	hsa-miR-3941	HITS-CLIP	23824327
MIRT072052	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT522732	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT522735	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT522734	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT522733	hsa-miR-3119	PAR-CLIP	23446348
MIRT522732	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT1118218	hsa-miR-103a	CLIP-seq
MIRT1118219	hsa-miR-105	CLIP-seq
MIRT1118220	hsa-miR-107	CLIP-seq
MIRT1118221	hsa-miR-1184	CLIP-seq
MIRT1118222	hsa-miR-1200	CLIP-seq
MIRT1118223	hsa-miR-1202	CLIP-seq
MIRT1118224	hsa-miR-1205	CLIP-seq
MIRT1118225	hsa-miR-1237	CLIP-seq
MIRT1118226	hsa-miR-1248	CLIP-seq
MIRT1118227	hsa-miR-1251	CLIP-seq
MIRT1118228	hsa-miR-1257	CLIP-seq
MIRT1118229	hsa-miR-1262	CLIP-seq
MIRT1118230	hsa-miR-1269	CLIP-seq
MIRT1118231	hsa-miR-1269b	CLIP-seq
MIRT1118232	hsa-miR-1273f	CLIP-seq
MIRT1118233	hsa-miR-1275	CLIP-seq
MIRT1118234	hsa-miR-1276	CLIP-seq
MIRT1118235	hsa-miR-1288	CLIP-seq
MIRT1118236	hsa-miR-129-5p	CLIP-seq
MIRT1118237	hsa-miR-130a	CLIP-seq
MIRT1118238	hsa-miR-130b	CLIP-seq
MIRT1118239	hsa-miR-1322	CLIP-seq
MIRT1118240	hsa-miR-140-5p	CLIP-seq
MIRT1118241	hsa-miR-143	CLIP-seq
MIRT1118242	hsa-miR-148a	CLIP-seq
MIRT1118243	hsa-miR-148b	CLIP-seq
MIRT1118244	hsa-miR-152	CLIP-seq
MIRT1118245	hsa-miR-214	CLIP-seq
MIRT1118246	hsa-miR-216a	CLIP-seq
MIRT1118247	hsa-miR-216b	CLIP-seq
MIRT1118248	hsa-miR-217	CLIP-seq
MIRT1118249	hsa-miR-219-1-3p	CLIP-seq
MIRT1118250	hsa-miR-224	CLIP-seq
MIRT1118251	hsa-miR-2467-5p	CLIP-seq
MIRT1118252	hsa-miR-301a	CLIP-seq
MIRT1118253	hsa-miR-301b	CLIP-seq
MIRT1118254	hsa-miR-3065-3p	CLIP-seq
MIRT1118255	hsa-miR-3074-5p	CLIP-seq
MIRT1118256	hsa-miR-3124-3p	CLIP-seq
MIRT1118257	hsa-miR-3126-3p	CLIP-seq
MIRT1118258	hsa-miR-3128	CLIP-seq
MIRT1118259	hsa-miR-3138	CLIP-seq
MIRT1118260	hsa-miR-3158-5p	CLIP-seq
MIRT1118261	hsa-miR-3159	CLIP-seq
MIRT1118262	hsa-miR-3160-3p	CLIP-seq
MIRT1118263	hsa-miR-3165	CLIP-seq
MIRT1118264	hsa-miR-3174	CLIP-seq
MIRT1118265	hsa-miR-3189-5p	CLIP-seq
MIRT1118266	hsa-miR-3192	CLIP-seq
MIRT1118267	hsa-miR-3199	CLIP-seq
MIRT1118268	hsa-miR-328	CLIP-seq
MIRT1118269	hsa-miR-330-3p	CLIP-seq
MIRT1118270	hsa-miR-345	CLIP-seq
MIRT1118271	hsa-miR-3591-5p	CLIP-seq
MIRT1118272	hsa-miR-3606	CLIP-seq
MIRT1118273	hsa-miR-3613-3p	CLIP-seq
MIRT1118274	hsa-miR-3614-5p	CLIP-seq
MIRT1118275	hsa-miR-3619-5p	CLIP-seq
MIRT1118276	hsa-miR-3647-3p	CLIP-seq
MIRT1118277	hsa-miR-365	CLIP-seq
MIRT1118278	hsa-miR-3650	CLIP-seq
MIRT1118279	hsa-miR-3666	CLIP-seq
MIRT1118280	hsa-miR-3934	CLIP-seq
MIRT1118281	hsa-miR-3935	CLIP-seq
MIRT1118282	hsa-miR-3972	CLIP-seq
MIRT1118283	hsa-miR-4259	CLIP-seq
MIRT1118284	hsa-miR-4271	CLIP-seq
MIRT1118285	hsa-miR-4291	CLIP-seq
MIRT1118286	hsa-miR-4295	CLIP-seq
MIRT1118287	hsa-miR-4307	CLIP-seq
MIRT1118288	hsa-miR-4314	CLIP-seq
MIRT1118289	hsa-miR-4328	CLIP-seq
MIRT1118290	hsa-miR-4418	CLIP-seq
MIRT1118291	hsa-miR-4422	CLIP-seq
MIRT1118292	hsa-miR-4481	CLIP-seq
MIRT1118293	hsa-miR-4487	CLIP-seq
MIRT1118294	hsa-miR-4488	CLIP-seq
MIRT1118295	hsa-miR-4515	CLIP-seq
MIRT1118296	hsa-miR-4525	CLIP-seq
MIRT1118297	hsa-miR-454	CLIP-seq
MIRT1118298	hsa-miR-455-5p	CLIP-seq
MIRT1118299	hsa-miR-4646-5p	CLIP-seq
MIRT1118300	hsa-miR-4665-5p	CLIP-seq
MIRT1118301	hsa-miR-4671-3p	CLIP-seq
MIRT1118302	hsa-miR-4679	CLIP-seq
MIRT1118303	hsa-miR-4687-3p	CLIP-seq
MIRT1118304	hsa-miR-4695-3p	CLIP-seq
MIRT1118305	hsa-miR-4697-5p	CLIP-seq
MIRT1118306	hsa-miR-4699-3p	CLIP-seq
MIRT1118307	hsa-miR-4701-3p	CLIP-seq
MIRT1118308	hsa-miR-4703-3p	CLIP-seq
MIRT1118309	hsa-miR-4708-5p	CLIP-seq
MIRT1118310	hsa-miR-4711-5p	CLIP-seq
MIRT1118311	hsa-miR-4715-5p	CLIP-seq
MIRT1118312	hsa-miR-4720-5p	CLIP-seq
MIRT1118313	hsa-miR-4723-5p	CLIP-seq
MIRT1118314	hsa-miR-4725-3p	CLIP-seq
MIRT1118315	hsa-miR-4740-5p	CLIP-seq
MIRT1118316	hsa-miR-4745-5p	CLIP-seq
MIRT1118317	hsa-miR-4747-5p	CLIP-seq
MIRT1118318	hsa-miR-4752	CLIP-seq
MIRT1118319	hsa-miR-4753-3p	CLIP-seq
MIRT1118320	hsa-miR-4755-3p	CLIP-seq
MIRT1118321	hsa-miR-4758-3p	CLIP-seq
MIRT1118322	hsa-miR-4758-5p	CLIP-seq
MIRT1118323	hsa-miR-4766-5p	CLIP-seq
MIRT1118324	hsa-miR-4770	CLIP-seq
MIRT1118325	hsa-miR-4776-3p	CLIP-seq
MIRT1118326	hsa-miR-4790-3p	CLIP-seq
MIRT1118327	hsa-miR-4792	CLIP-seq
MIRT1118328	hsa-miR-4799-3p	CLIP-seq
MIRT1118329	hsa-miR-4800-5p	CLIP-seq
MIRT1118330	hsa-miR-488	CLIP-seq
MIRT1118331	hsa-miR-491-3p	CLIP-seq
MIRT1118332	hsa-miR-500a	CLIP-seq
MIRT1118333	hsa-miR-501-3p	CLIP-seq
MIRT1118334	hsa-miR-502-3p	CLIP-seq
MIRT1118335	hsa-miR-509-3-5p	CLIP-seq
MIRT1118336	hsa-miR-509-3p	CLIP-seq
MIRT1118337	hsa-miR-509-5p	CLIP-seq
MIRT1118338	hsa-miR-513a-3p	CLIP-seq
MIRT1118339	hsa-miR-520d-5p	CLIP-seq
MIRT1118340	hsa-miR-524-5p	CLIP-seq
MIRT1118341	hsa-miR-548t	CLIP-seq
MIRT1118342	hsa-miR-558	CLIP-seq
MIRT1118343	hsa-miR-571	CLIP-seq
MIRT1118344	hsa-miR-578	CLIP-seq
MIRT1118345	hsa-miR-587	CLIP-seq
MIRT1118346	hsa-miR-605	CLIP-seq
MIRT1118347	hsa-miR-617	CLIP-seq
MIRT1118348	hsa-miR-625	CLIP-seq
MIRT1118349	hsa-miR-647	CLIP-seq
MIRT1118350	hsa-miR-659	CLIP-seq
MIRT1118351	hsa-miR-761	CLIP-seq
MIRT1118352	hsa-miR-892a	CLIP-seq
MIRT1118353	hsa-miR-921	CLIP-seq
MIRT1118354	hsa-miR-922	CLIP-seq
MIRT1118355	hsa-miR-1207-5p	CLIP-seq
MIRT1118356	hsa-miR-1208	CLIP-seq
MIRT1118357	hsa-miR-1227	CLIP-seq
MIRT1118233	hsa-miR-1275	CLIP-seq
MIRT1118358	hsa-miR-1281	CLIP-seq
MIRT1118359	hsa-miR-1299	CLIP-seq
MIRT1118237	hsa-miR-130a	CLIP-seq
MIRT1118238	hsa-miR-130b	CLIP-seq
MIRT1118360	hsa-miR-142-3p	CLIP-seq
MIRT1118242	hsa-miR-148a	CLIP-seq
MIRT1118243	hsa-miR-148b	CLIP-seq
MIRT1118244	hsa-miR-152	CLIP-seq
MIRT1118249	hsa-miR-219-1-3p	CLIP-seq
MIRT1118252	hsa-miR-301a	CLIP-seq
MIRT1118253	hsa-miR-301b	CLIP-seq
MIRT1118257	hsa-miR-3126-3p	CLIP-seq
MIRT1118258	hsa-miR-3128	CLIP-seq
MIRT1118268	hsa-miR-328	CLIP-seq
MIRT1118279	hsa-miR-3666	CLIP-seq
MIRT1118361	hsa-miR-3910	CLIP-seq
MIRT1118362	hsa-miR-4252	CLIP-seq
MIRT1118283	hsa-miR-4259	CLIP-seq
MIRT1118363	hsa-miR-4280	CLIP-seq
MIRT1118286	hsa-miR-4295	CLIP-seq
MIRT1118287	hsa-miR-4307	CLIP-seq
MIRT1118364	hsa-miR-4318	CLIP-seq
MIRT1118365	hsa-miR-4420	CLIP-seq
MIRT1118294	hsa-miR-4488	CLIP-seq
MIRT1118297	hsa-miR-454	CLIP-seq
MIRT1118366	hsa-miR-4633-5p	CLIP-seq
MIRT1118367	hsa-miR-4662a-5p	CLIP-seq
MIRT1118300	hsa-miR-4665-5p	CLIP-seq
MIRT1118301	hsa-miR-4671-3p	CLIP-seq
MIRT1118368	hsa-miR-4693-5p	CLIP-seq
MIRT1118305	hsa-miR-4697-5p	CLIP-seq
MIRT1118369	hsa-miR-4720-3p	CLIP-seq
MIRT1118312	hsa-miR-4720-5p	CLIP-seq
MIRT1118370	hsa-miR-4729	CLIP-seq
MIRT1118371	hsa-miR-4736	CLIP-seq
MIRT1118317	hsa-miR-4747-5p	CLIP-seq
MIRT1118372	hsa-miR-4763-3p	CLIP-seq
MIRT1118328	hsa-miR-4799-3p	CLIP-seq
MIRT1118373	hsa-miR-4804-3p	CLIP-seq
MIRT1118374	hsa-miR-5096	CLIP-seq
MIRT1118375	hsa-miR-520a-5p	CLIP-seq
MIRT1118376	hsa-miR-525-5p	CLIP-seq
MIRT1118377	hsa-miR-532-5p	CLIP-seq
MIRT1118343	hsa-miR-571	CLIP-seq
MIRT1118350	hsa-miR-659	CLIP-seq
MIRT1118378	hsa-miR-7	CLIP-seq
MIRT1118379	hsa-miR-759	CLIP-seq
MIRT1118380	hsa-miR-875-3p	CLIP-seq
MIRT1118352	hsa-miR-892a	CLIP-seq
MIRT1118357	hsa-miR-1227	CLIP-seq
MIRT2033463	hsa-miR-25	CLIP-seq
MIRT2033464	hsa-miR-302f	CLIP-seq
MIRT1118260	hsa-miR-3158-5p	CLIP-seq
MIRT2033465	hsa-miR-3188	CLIP-seq
MIRT2033466	hsa-miR-32	CLIP-seq
MIRT2033467	hsa-miR-363	CLIP-seq
MIRT2033468	hsa-miR-367	CLIP-seq
MIRT1118362	hsa-miR-4252	CLIP-seq
MIRT1118308	hsa-miR-4703-3p	CLIP-seq
MIRT1118319	hsa-miR-4753-3p	CLIP-seq
MIRT2033469	hsa-miR-4762-3p	CLIP-seq
MIRT1118323	hsa-miR-4766-5p	CLIP-seq
MIRT2033470	hsa-miR-4768-5p	CLIP-seq
MIRT1118339	hsa-miR-520d-5p	CLIP-seq
MIRT1118340	hsa-miR-524-5p	CLIP-seq
MIRT2033471	hsa-miR-643	CLIP-seq
MIRT2033472	hsa-miR-92a	CLIP-seq
MIRT2033473	hsa-miR-92b	CLIP-seq
MIRT2263859	hsa-miR-518a-5p	CLIP-seq
MIRT2263860	hsa-miR-527	CLIP-seq
MIRT2263861	hsa-miR-106a	CLIP-seq
MIRT2263862	hsa-miR-106b	CLIP-seq
MIRT2263863	hsa-miR-17	CLIP-seq
MIRT2263864	hsa-miR-20a	CLIP-seq
MIRT2263865	hsa-miR-20b	CLIP-seq
MIRT2263866	hsa-miR-2276	CLIP-seq
MIRT2263867	hsa-miR-302a	CLIP-seq
MIRT2263868	hsa-miR-302b	CLIP-seq
MIRT2263869	hsa-miR-302c	CLIP-seq
MIRT2263870	hsa-miR-302d	CLIP-seq
MIRT2263871	hsa-miR-302e	CLIP-seq
MIRT2263872	hsa-miR-3074-3p	CLIP-seq
MIRT2263873	hsa-miR-3125	CLIP-seq
MIRT1118258	hsa-miR-3128	CLIP-seq
MIRT2263874	hsa-miR-3202	CLIP-seq
MIRT1118274	hsa-miR-3614-5p	CLIP-seq
MIRT2263875	hsa-miR-372	CLIP-seq
MIRT2263876	hsa-miR-373	CLIP-seq
MIRT2263877	hsa-miR-377	CLIP-seq
MIRT2263878	hsa-miR-3916	CLIP-seq
MIRT2263879	hsa-miR-4277	CLIP-seq
MIRT1118289	hsa-miR-4328	CLIP-seq
MIRT2263880	hsa-miR-4436b-5p	CLIP-seq
MIRT2263881	hsa-miR-4476	CLIP-seq
MIRT2263882	hsa-miR-4533	CLIP-seq
MIRT2263883	hsa-miR-4772-3p	CLIP-seq
MIRT2263884	hsa-miR-493	CLIP-seq
MIRT2263885	hsa-miR-512-3p	CLIP-seq
MIRT2263859	hsa-miR-518a-5p	CLIP-seq
MIRT2263886	hsa-miR-519d	CLIP-seq
MIRT2263887	hsa-miR-520a-3p	CLIP-seq
MIRT2263888	hsa-miR-520b	CLIP-seq
MIRT2263889	hsa-miR-520c-3p	CLIP-seq
MIRT2263890	hsa-miR-520d-3p	CLIP-seq
MIRT2263891	hsa-miR-520e	CLIP-seq
MIRT2263892	hsa-miR-520g	CLIP-seq
MIRT2263893	hsa-miR-520h	CLIP-seq
MIRT2263860	hsa-miR-527	CLIP-seq
MIRT2263894	hsa-miR-544	CLIP-seq
MIRT2263895	hsa-miR-642b	CLIP-seq
MIRT1118350	hsa-miR-659	CLIP-seq
MIRT2263896	hsa-miR-889	CLIP-seq
MIRT1118354	hsa-miR-922	CLIP-seq
MIRT2263897	hsa-miR-93	CLIP-seq
MIRT1118356	hsa-miR-1208	CLIP-seq
MIRT2390321	hsa-miR-3187-3p	CLIP-seq
MIRT1118362	hsa-miR-4252	CLIP-seq
MIRT2390322	hsa-miR-4273	CLIP-seq
MIRT2390323	hsa-miR-4435	CLIP-seq
MIRT1118366	hsa-miR-4633-5p	CLIP-seq
MIRT1118367	hsa-miR-4662a-5p	CLIP-seq
MIRT2390324	hsa-miR-4677-5p	CLIP-seq
MIRT2390325	hsa-miR-4701-5p	CLIP-seq
MIRT1118370	hsa-miR-4729	CLIP-seq
MIRT1118377	hsa-miR-532-5p	CLIP-seq
MIRT2390326	hsa-miR-548s	CLIP-seq
MIRT2390327	hsa-miR-588	CLIP-seq
MIRT2438447	hsa-miR-3183	CLIP-seq
MIRT2438448	hsa-miR-3667-5p	CLIP-seq
MIRT2438449	hsa-miR-3978	CLIP-seq
MIRT2438450	hsa-miR-4723-3p	CLIP-seq
MIRT1118357	hsa-miR-1227	CLIP-seq
MIRT2563074	hsa-miR-1914	CLIP-seq
MIRT2563075	hsa-miR-2355-5p	CLIP-seq
MIRT2563076	hsa-miR-2467-3p	CLIP-seq
MIRT2563077	hsa-miR-33a	CLIP-seq
MIRT2563078	hsa-miR-33b	CLIP-seq
MIRT2563079	hsa-miR-3678-3p	CLIP-seq
MIRT2563080	hsa-miR-3679-3p	CLIP-seq
MIRT2563081	hsa-miR-4327	CLIP-seq
MIRT2033469	hsa-miR-4762-3p	CLIP-seq
MIRT1118323	hsa-miR-4766-5p	CLIP-seq
MIRT2263892	hsa-miR-520g	CLIP-seq
MIRT2263893	hsa-miR-520h	CLIP-seq
MIRT2563082	hsa-miR-543	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
HIC1	Repression	24076391

Show/Hide all(77)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0001540	Function	Amyloid-beta binding	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	8626535
GO:0005041	Function	Low-density lipoprotein particle receptor activity	IEA
GO:0005041	Function	Low-density lipoprotein particle receptor activity	TAS	20005821
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	12950167, 17548821, 19116273, 20223215, 32814053, 33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IEA
GO:0005875	Component	Microtubule associated complex	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	30873003
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS
GO:0005886	Component	Plasma membrane	TAS
GO:0005901	Component	Caveola	IBA
GO:0005901	Component	Caveola	IDA	11369809
GO:0006508	Process	Proteolysis	NAS	11152697
GO:0006629	Process	Lipid metabolic process	NAS	11152697
GO:0006629	Process	Lipid metabolic process	TAS	8626535
GO:0006897	Process	Endocytosis	IDA	8626535
GO:0006897	Process	Endocytosis	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS
GO:0007268	Process	Chemical synaptic transmission	IEA
GO:0008035	Function	High-density lipoprotein particle binding	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IC	11152697
GO:0016020	Component	Membrane	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	NAS	11152697
GO:0019894	Function	Kinesin binding	IEA
GO:0021517	Process	Ventral spinal cord development	IBA
GO:0021517	Process	Ventral spinal cord development	IEA
GO:0021541	Process	Ammon gyrus development	IEA
GO:0021541	Process	Ammon gyrus development	ISS
GO:0021766	Process	Hippocampus development	IEA
GO:0021819	Process	Layer formation in cerebral cortex	IEA
GO:0021819	Process	Layer formation in cerebral cortex	ISS
GO:0021819	Process	Layer formation in cerebral cortex	ISS
GO:0021987	Process	Cerebral cortex development	IEA
GO:0030229	Function	Very-low-density lipoprotein particle receptor activity	IDA	8626535
GO:0030229	Function	Very-low-density lipoprotein particle receptor activity	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0034185	Function	Apolipoprotein binding	IC	8626535
GO:0034185	Function	Apolipoprotein binding	IEA
GO:0038024	Function	Cargo receptor activity	NAS	10571240
GO:0038025	Function	Reelin receptor activity	IEA
GO:0038025	Function	Reelin receptor activity	ISS
GO:0038026	Process	Reelin-mediated signaling pathway	IEA
GO:0038026	Process	Reelin-mediated signaling pathway	ISS
GO:0038026	Process	Reelin-mediated signaling pathway	ISS
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0042981	Process	Regulation of apoptotic process	ISS
GO:0043025	Component	Neuronal cell body	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	ISS
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0045088	Process	Regulation of innate immune response	IEA
GO:0045088	Process	Regulation of innate immune response	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048306	Function	Calcium-dependent protein binding	IEA
GO:0048813	Process	Dendrite morphogenesis	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	ISS
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	IEA
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	ISS
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:0071397	Process	Cellular response to cholesterol	IEA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1900006	Process	Positive regulation of dendrite development	IEA
GO:1900006	Process	Positive regulation of dendrite development	ISS
GO:2001222	Process	Regulation of neuron migration	ISS

MIM	HGNC	e!Ensembl
602600	6700	ENSG00000157193

Protein

UniProt ID

Q14114

Protein name

Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2)

Protein function

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands (PubMed:12899622, PubMed:12950167, PubMed:20223215, PubMed:30873003). LRP8 participates in transmitting the extracellular Reelin signal to intracellular signa

PDB

3A7Q , 5B4X , 5B4Y , 7UCX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00057	Ldl_recept_a	45 → 81	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	84 → 122	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	125 → 163	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	165 → 201	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	204 → 245	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	257 → 294	Low-density lipoprotein receptor domain class A	Repeat
PF00057	Ldl_recept_a	297 → 333	Low-density lipoprotein receptor domain class A	Repeat
PF14670	FXa_inhibition	340 → 374		Domain
PF00058	Ldl_recept_b	462 → 506	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	509 → 549	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	552 → 593	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	596 → 638	Low-density lipoprotein receptor repeat class B	Repeat
PF00058	Ldl_recept_b	639 → 679	Low-density lipoprotein receptor repeat class B	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed mainly in brain and placenta. Also expressed in platelets and megakaryocytic cells. Not expressed in the liver. {ECO:0000269|PubMed:10218790, ECO:0000269|PubMed:10508213}.

Sequence

MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCI
PSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEA
TCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCL
AAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDE
AAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCR
GDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC
TCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGK
SPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMD
KASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLS
EPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYW
VDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGL
EISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCA
CPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSL
TAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALL
CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPAAISSFDRP
LWAEPCLGETREPEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKSKRVALSLEDD
GLP

Sequence length

963

Interactions

View interactions

	Reactome
			Platelet sensitization by LDL Retinoid metabolism and transport

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes nephropathy	N/A	N/A	GWAS
Hepatocellular Carcinoma	Hepatocellular carcinoma	We finally identified LRP8 as a key gene that can drive HCC cell to acquire sorafenib resistance.	32312520	CBGDA

Show/Hide Text Mining Associations (26)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	35466940, 35886870, 38093390
Autistic Disorder	Associate	36039581
Behcet Syndrome	Inhibit	39191728
Bipolar Disorder	Associate	39191728
Blood Platelet Disorders	Associate	10508213
Carcinoma Non Small Cell Lung	Stimulate	35246020
Cognition Disorders	Associate	38093390
Colorectal Neoplasms	Associate	37770979
Coronary Artery Disease	Associate	17847002, 23524007, 24867879
Coronary Artery Disease Autosomal Dominant 1	Associate	24867879
Fetal Growth Retardation	Associate	16642433
Gastrointestinal Neoplasms	Associate	36753304
Learning Disabilities	Associate	29240611
Lung Neoplasms	Associate	35246020
Medulloblastoma	Associate	36273157
Mental Disorders	Associate	36753304
Myocardial Infarction	Associate	17847002, 19439088, 23524007, 24867879
Neoplasms	Associate	35246020, 36273157
Neurodegenerative Diseases	Associate	38093390
Plaque Amyloid	Associate	35466940
Pre Eclampsia	Associate	16642433
Prostatic Neoplasms	Associate	30444038
Pulmonary Arterial Hypertension	Associate	30081553
Stomach Neoplasms	Associate	24260584
Thrombosis	Associate	12807892
Triglyceride Storage Disease Type I	Associate	27853278

LRP8 (LDL receptor related protein 8)