TRIM25 (tripartite motif containing 25)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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7706 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Tripartite motif containing 25 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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TRIM25 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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EFP, RNF147, Z147, ZNF147 |
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Chromosome
Chromosome number
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17 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17q22 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presen |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | Q14258 | ||||||||||||||||||||
| Protein name | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquiti | ||||||||||||||||||||
| Protein function | Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase (PubMed:16352599). Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 (PubMed:17392790, PubMed:29357390, PubMed:30193849, PubMed:31710640, | ||||||||||||||||||||
| PDB | 4CFG , 4LTB , 5EYA , 5FER , 5NT1 , 5NT2 , 6FLM , 6FLN | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in breast tumors (at protein level). Ubiquitous. {ECO:0000269|PubMed:15130519, ECO:0000269|PubMed:22452784}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 630 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||