Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	768
Gene name Gene Name - the full gene name approved by the HGNC.	Carbonic anhydrase 9
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CA9
Synonyms (NCBI Gene) Gene synonyms aliases	CAIX, MN
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption,

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miRTarBase ID	miRNA	Experiments	Reference
MIRT027439	hsa-miR-98-5p	Microarray	19088304
MIRT028954	hsa-miR-26b-5p	Microarray	19088304
MIRT1954468	hsa-miR-1229	CLIP-seq
MIRT1954469	hsa-miR-1245b-3p	CLIP-seq
MIRT1954470	hsa-miR-149	CLIP-seq
MIRT1954471	hsa-miR-3064-5p	CLIP-seq
MIRT1954472	hsa-miR-342-3p	CLIP-seq
MIRT1954473	hsa-miR-3652	CLIP-seq
MIRT1954474	hsa-miR-4330	CLIP-seq
MIRT1954475	hsa-miR-4430	CLIP-seq
MIRT1954476	hsa-miR-4505	CLIP-seq
MIRT1954477	hsa-miR-4794	CLIP-seq
MIRT1954468	hsa-miR-1229	CLIP-seq
MIRT1954469	hsa-miR-1245b-3p	CLIP-seq
MIRT1954470	hsa-miR-149	CLIP-seq
MIRT1954471	hsa-miR-3064-5p	CLIP-seq
MIRT1954473	hsa-miR-3652	CLIP-seq
MIRT1954474	hsa-miR-4330	CLIP-seq
MIRT1954475	hsa-miR-4430	CLIP-seq
MIRT1954476	hsa-miR-4505	CLIP-seq
MIRT1954477	hsa-miR-4794	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
AHR	Repression	19154183
ARNT	Activation	22387692
ATF4	Unknown	19564335
EP300	Activation	16270297
EPAS1	Activation	12171890
ETS1	Repression	18381358
HDAC4	Unknown	20110259
HIF1A	Activation	12171890;19154183
HIF1A	Unknown	17486380;19238077
SP1	Activation	16270297
SP1	Unknown	12615703
SP3	Unknown	12615703
VHL	Unknown	15754010

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IEA
GO:0002009	Process	Morphogenesis of an epithelium	IEA
GO:0004089	Function	Carbonate dehydratase activity	IBA
GO:0004089	Function	Carbonate dehydratase activity	IDA	18703501, 19805286
GO:0004089	Function	Carbonate dehydratase activity	IEA
GO:0004089	Function	Carbonate dehydratase activity	IMP	17314045, 17705204, 19206230
GO:0004089	Function	Carbonate dehydratase activity	TAS	8661007
GO:0005515	Function	Protein binding	IPI	26871637, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22087255
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0008270	Function	Zinc ion binding	IDA	18703501, 19805286
GO:0008270	Function	Zinc ion binding	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	8661007
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016829	Function	Lyase activity	IEA
GO:0031528	Component	Microvillus membrane	IEA
GO:0033574	Process	Response to testosterone	IEA
GO:0042995	Component	Cell projection	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0046903	Process	Secretion	IEA
GO:0140677	Function	Molecular function activator activity	IDA	29564477

MIM	HGNC	e!Ensembl
603179	1383	ENSG00000107159

Protein

UniProt ID

Q16790

Protein name

Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonate dehydratase IX) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1)

Protein function

Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). {ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18703501, ECO:0000269|Pu

PDB

2HKF , 3IAI , 5DVX , 5FL4 , 5FL5 , 5FL6 , 6FE0 , 6FE1 , 6FE2 , 6G98 , 6G9U , 6QN2 , 6QN5 , 6QN6 , 6QUT , 6RQN , 6RQQ , 6RQU , 6RQW , 6TL5 , 6TL6 , 6Y74 , 7POM , 8CO0 , 8Q18 , 8Q19 , 8Q1A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00194	Carb_anhydrase	140 → 389	Eukaryotic-type carbonic anhydrase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.

Sequence

MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA

Sequence length

459

Interactions

View interactions

	KEGG		Reactome
	Nitrogen metabolism Metabolic pathways		Regulation of gene expression by Hypoxia-inducible Factor Reversible hydration of carbon dioxide

CA9 (carbonic anhydrase 9)