Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7592
Gene name	Zinc finger protein 41
Gene symbol	ZNF41
Synonyms (NCBI Gene)	MRX89
Chromosome	X
Chromosome location	Xp11.3
Summary	This gene encodes a protein that contains KRAB-A and KRAB-B domains multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. An initial study suggested that this gene may be associated with X-linked cognitiv

Show/Hide all (35)

miRTarBase ID	miRNA	Experiments	Reference
MIRT439204	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439204	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1524013	hsa-miR-25	CLIP-seq
MIRT1524014	hsa-miR-32	CLIP-seq
MIRT1524015	hsa-miR-363	CLIP-seq
MIRT1524016	hsa-miR-367	CLIP-seq
MIRT1524017	hsa-miR-4325	CLIP-seq
MIRT1524018	hsa-miR-548c-3p	CLIP-seq
MIRT1524019	hsa-miR-92a	CLIP-seq
MIRT1524020	hsa-miR-92b	CLIP-seq
MIRT1524021	hsa-miR-1224-5p	CLIP-seq
MIRT1524022	hsa-miR-153	CLIP-seq
MIRT1524023	hsa-miR-2964a-3p	CLIP-seq
MIRT1524024	hsa-miR-337-3p	CLIP-seq
MIRT1524025	hsa-miR-448	CLIP-seq
MIRT1524026	hsa-miR-4668-5p	CLIP-seq
MIRT1524027	hsa-miR-4751	CLIP-seq
MIRT1524028	hsa-miR-4789-5p	CLIP-seq
MIRT1524029	hsa-miR-586	CLIP-seq
MIRT1524030	hsa-miR-617	CLIP-seq
MIRT2158386	hsa-miR-145	CLIP-seq
MIRT2377850	hsa-miR-1252	CLIP-seq
MIRT2377851	hsa-miR-1269	CLIP-seq
MIRT2377852	hsa-miR-1269b	CLIP-seq
MIRT2377853	hsa-miR-1288	CLIP-seq
MIRT2158386	hsa-miR-145	CLIP-seq
MIRT2377854	hsa-miR-1825	CLIP-seq
MIRT2377855	hsa-miR-199a-5p	CLIP-seq
MIRT2377856	hsa-miR-199b-5p	CLIP-seq
MIRT2377857	hsa-miR-3124-3p	CLIP-seq
MIRT2377858	hsa-miR-3180-5p	CLIP-seq
MIRT2377859	hsa-miR-4515	CLIP-seq
MIRT2377860	hsa-miR-4740-5p	CLIP-seq
MIRT2377861	hsa-miR-511	CLIP-seq
MIRT2377858	hsa-miR-3180-5p	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
314995	13107	ENSG00000147124

P51814

Protein name

Zinc finger protein 41

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01352	KRAB	68 → 109	KRAB box	Family
PF00096	zf-C2H2	313 → 335	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	369 → 391	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	397 → 419	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	425 → 447	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	453 → 475	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	481 → 503	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	509 → 531	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	537 → 559	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	565 → 587	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	593 → 615	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	621 → 643	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	649 → 671	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	677 → 699	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	706 → 727	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	733 → 755	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	761 → 783	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	789 → 811	Zinc finger, C2H2 type	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:14628291}.

Sequence

MAANGDSPPWSPALAAEGRGSSCEVRRERTPEARIHSVKRYPDLSPGPKGRSSADHAALN
SIVSLQASVSFEDVTVDFSKEEWQHLDPAQRRLYWDVTLENYSHLLSVGYQIPKSEAAFK
LEQGEGPWMLEGEAPHQSCSGEAIGKMQQQGIPGGIFFHCERFDQPIGEDSLCSILEELW
QDNDQLEQRQENQNNLLSHVKVLIKERGYEHKNIEKIIHVTTKLVPSIKRLHNCDTILKH
TLNSHNHNRNSATKNLGKIFGNGNNFPHSPSSTKNENAKTGANSCEHDHYEKHLSHKQAP
THHQKIHPEEKLYVCTECVMGFTQKSHLFEHQRIHAGEKSRECDKSNKVFPQKPQVDVHP
SVYTGEKPYLCTQCGKVFTLKSNLITHQKIHTGQKPYKCSECGKAFFQRSDLFRHLRIHT
GEKPYECSECGKGFSQNSDLSIHQKTHTGEKHYECNECGKAFTRKSALRMHQRIHTGEKP
YVCADCGKAFIQKSHFNTHQRIHTGEKPYECSDCGKSFTKKSQLHVHQRIHTGEKPYICT
ECGKVFTHRTNLTTHQKTHTGEKPYMCAECGKAFTDQSNLIKHQKTHTGEKPYKCNGCGK
AFIWKSRLKIHQKSHIGERHYECKDCGKAFIQKSTLSVHQRIHTGEKPYVCPECGKAFIQ
KSHFIAHHRIHTGEKPYECSDCGKCFTKKSQLRVHQKIHTGEKPNICAECGKAFTDRSNL
ITHQKIHTREKPYECGDCGKTFTWKSRLNIHQKSHTGERHYECSKCGKAFIQKATLSMHQ
IIHTGKKPYACTECQKAFTDRSNLIKHQKMHSGEKRYKASD

Sequence length

821

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Abnormality of neuronal migration	Benign	rs368078047	RCV000201376
Cholangiocarcinoma	-	rs5905607	RCV006203196
Gastric cancer	-	rs5905607	RCV006203194
Global developmental delay	Uncertain significance	rs373338312	RCV002226839
History of neurodevelopmental disorder	Benign; Conflicting classifications of pathogenicity; Uncertain significance	rs144970008, rs60022654, rs148585367, rs144904486, rs145129774	RCV000720986 RCV000721014 RCV000721054 RCV000721077 RCV000720960
Intellectual disability	Uncertain significance	rs373338312	RCV002226839
Non-syndromic X-linked intellectual disability	Uncertain significance	rs200168272, rs372112867	RCV000403527 RCV000305148
Seizure	Uncertain significance	rs373338312	RCV002226839
Uterine carcinosarcoma	-	rs5905607	RCV006203195
ZNF41-related disorder	Benign; Uncertain significance; Likely benign	rs2498170, rs200141273, rs201140907, rs868329425, rs918503644, rs370856827	RCV003935072 RCV003948567 RCV003944812 RCV003412127 RCV003405893 RCV003947176

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Cognition Disorders	Associate	14628291
Intellectual Disability	Associate	14628291, 23871722
Mental Disorders	Associate	14628291
Mental Retardation X Linked	Associate	14628291, 16385466

ZNF41 (zinc finger protein 41)