Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7533
Gene name Gene Name - the full gene name approved by the HGNC.
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
YWHAH
Synonyms (NCBI Gene) Gene synonyms aliases
YWHA1
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q12.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to th
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021116 hsa-miR-186-5p Sequencing 20371350
MIRT027235 hsa-miR-103a-3p Sequencing 20371350
MIRT028247 hsa-miR-33a-5p Sequencing 20371350
MIRT028327 hsa-miR-32-5p Sequencing 20371350
MIRT032075 hsa-miR-16-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002028 Process Regulation of sodium ion transport IDA 16728661
GO:0003779 Function Actin binding IEA
GO:0005159 Function Insulin-like growth factor receptor binding ISS
GO:0005515 Function Protein binding IPI 10713667, 11697890, 12524439, 14676191, 14743216, 15023544, 16545136, 16672277, 16775625, 16959763, 17700517, 17962809, 17979178, 18045992, 18242179, 18397886, 18458160, 19172738, 19553522, 19615732, 19640509, 19860830, 20642453, 20936779, 21988832, 23075850, 23572552, 23622247, 237
GO:0005737 Component Cytoplasm ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
113508 12853 ENSG00000128245
Protein
UniProt ID Q04917
Protein name 14-3-3 protein eta (Protein AS1)
Protein function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally resu
PDB 2C63 , 2C74 , 7NMZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00244 14-03-2003 10 234 14-3-3 protein Domain
Tissue specificity TISSUE SPECIFICITY: Expressed mainly in the brain and present in other tissues albeit at lower levels.
Sequence
Sequence length 246
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cell cycle
Oocyte meiosis
PI3K-Akt signaling pathway
Hippo signaling pathway
Hepatitis C
Viral carcinogenesis
  Activation of BAD and translocation to mitochondria
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cardiomyopathy Cardiomyopathies, Primary, Cardiomyopathies rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377
View all (900 more)
18342293
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Adenoma Oxyphilic Associate 29704241
Arthritis Rheumatoid Associate 24751211, 26449724, 35008549
Arthritis Rheumatoid Stimulate 30915732
Bipolar Disorder Associate 19160447
Breast Neoplasms Associate 20534901
Carcinoma Ductal Associate 20534901, 21197096
Carcinoma Hepatocellular Associate 30572915
Cartilage Diseases Inhibit 35008549
Cognitive Dysfunction Associate 19160447
Glioma Associate 26370624