Gene Gene information from NCBI Gene database.
Entrez ID 7533
Gene name Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Gene symbol YWHAH
Synonyms (NCBI Gene)
YWHA1
Chromosome 22
Chromosome location 22q12.3
Summary This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to th
miRNA miRNA information provided by mirtarbase database.
605
miRTarBase ID miRNA Experiments Reference
MIRT021116 hsa-miR-186-5p Sequencing 20371350
MIRT027235 hsa-miR-103a-3p Sequencing 20371350
MIRT028247 hsa-miR-33a-5p Sequencing 20371350
MIRT028327 hsa-miR-32-5p Sequencing 20371350
MIRT032075 hsa-miR-16-5p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0002028 Process Regulation of sodium ion transport IDA 16728661
GO:0003779 Function Actin binding IEA
GO:0005159 Function Insulin-like growth factor receptor binding ISS
GO:0005515 Function Protein binding IPI 10713667, 11697890, 12524439, 14676191, 14690447, 14743216, 15023544, 15677482, 16545136, 16672277, 16775625, 16959763, 17700517, 17962809, 17979178, 18045992, 18242179, 18397886, 18458160, 19172738, 19553522, 19615732, 19640509, 19860830, 20642453, 20936779, 21988832, 23075850, 235
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
113508 12853 ENSG00000128245
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q04917
Protein name 14-3-3 protein eta (Protein AS1)
Protein function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally resu
PDB 2C63 , 2C74 , 7NMZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00244 14-03-2003 10 234 14-3-3 protein Domain
Tissue specificity TISSUE SPECIFICITY: Expressed mainly in the brain and present in other tissues albeit at lower levels.
Sequence
Sequence length 246
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell cycle
Oocyte meiosis
PI3K-Akt signaling pathway
Hippo signaling pathway
Hepatitis C
Viral carcinogenesis
  Activation of BAD and translocation to mitochondria
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHIES CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, EXPERIMENTAL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PRIMARY CARDIOMYOPATHY Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenoma Oxyphilic Associate 29704241
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Associate 24751211, 26449724, 35008549
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Stimulate 30915732
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Associate 19160447
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Associate 20534901
★☆☆☆☆
Found in Text Mining only
Carcinoma Ductal Associate 20534901, 21197096
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 30572915
★☆☆☆☆
Found in Text Mining only
Cartilage Diseases Inhibit 35008549
★☆☆☆☆
Found in Text Mining only
Cognitive Dysfunction Associate 19160447
★☆☆☆☆
Found in Text Mining only
Glioma Associate 26370624
★☆☆☆☆
Found in Text Mining only