Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7512
Gene name Gene Name - the full gene name approved by the HGNC.	X-prolyl aminopeptidase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	XPNPEP2
Synonyms (NCBI Gene) Gene synonyms aliases	AEACEI, APP2
Disease Acronyms (UniProt) Disease acronyms from UniProt database	AEACEI
Chromosome Chromosome number	X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	Xq26.1
Summary Summary of gene provided in NCBI Entrez Gene.	Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the `pita bread fold` family and occ

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miRTarBase ID	miRNA	Experiments	Reference
MIRT504165	hsa-miR-1272	PAR-CLIP	20371350
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT504162	hsa-miR-8069	PAR-CLIP	20371350
MIRT504161	hsa-miR-4502	PAR-CLIP	20371350
MIRT504165	hsa-miR-1272	PAR-CLIP	20371350
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT504162	hsa-miR-8069	PAR-CLIP	20371350
MIRT504161	hsa-miR-4502	PAR-CLIP	20371350
MIRT504165	hsa-miR-1272	PAR-CLIP	22012620
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	22012620
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	22012620
MIRT504162	hsa-miR-8069	PAR-CLIP	22012620
MIRT528572	hsa-miR-885-3p	PAR-CLIP	22012620
MIRT504161	hsa-miR-4502	PAR-CLIP	22012620
MIRT504165	hsa-miR-1272	PAR-CLIP	23446348
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT504162	hsa-miR-8069	PAR-CLIP	23446348
MIRT504161	hsa-miR-4502	PAR-CLIP	23446348
MIRT504165	hsa-miR-1272	PAR-CLIP	23446348
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT504162	hsa-miR-8069	PAR-CLIP	23446348
MIRT504161	hsa-miR-4502	PAR-CLIP	23446348
MIRT504165	hsa-miR-1272	PAR-CLIP	23446348
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT504162	hsa-miR-8069	PAR-CLIP	23446348
MIRT504161	hsa-miR-4502	PAR-CLIP	23446348
MIRT504165	hsa-miR-1272	PAR-CLIP	20371350
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT504162	hsa-miR-8069	PAR-CLIP	20371350
MIRT504161	hsa-miR-4502	PAR-CLIP	20371350
MIRT504165	hsa-miR-1272	PAR-CLIP	20371350
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT504162	hsa-miR-8069	PAR-CLIP	20371350
MIRT504161	hsa-miR-4502	PAR-CLIP	20371350
MIRT504165	hsa-miR-1272	PAR-CLIP	22012620
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	22012620
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	22012620
MIRT504162	hsa-miR-8069	PAR-CLIP	22012620
MIRT528572	hsa-miR-885-3p	PAR-CLIP	22012620
MIRT504161	hsa-miR-4502	PAR-CLIP	22012620
MIRT504165	hsa-miR-1272	PAR-CLIP	23446348
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT504162	hsa-miR-8069	PAR-CLIP	23446348
MIRT504161	hsa-miR-4502	PAR-CLIP	23446348
MIRT504165	hsa-miR-1272	PAR-CLIP	23446348
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT504162	hsa-miR-8069	PAR-CLIP	23446348
MIRT504161	hsa-miR-4502	PAR-CLIP	23446348
MIRT504165	hsa-miR-1272	PAR-CLIP	23446348
MIRT504164	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT504163	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT504162	hsa-miR-8069	PAR-CLIP	23446348
MIRT504161	hsa-miR-4502	PAR-CLIP	23446348
MIRT1496211	hsa-miR-1292	CLIP-seq
MIRT1496212	hsa-miR-1293	CLIP-seq
MIRT1496213	hsa-miR-146b-3p	CLIP-seq
MIRT1496214	hsa-miR-1915	CLIP-seq
MIRT1496215	hsa-miR-3064-5p	CLIP-seq
MIRT1496216	hsa-miR-3173-5p	CLIP-seq
MIRT1496217	hsa-miR-3652	CLIP-seq
MIRT1496218	hsa-miR-4430	CLIP-seq
MIRT1496219	hsa-miR-4471	CLIP-seq
MIRT1496220	hsa-miR-4483	CLIP-seq
MIRT1496221	hsa-miR-4505	CLIP-seq
MIRT1496222	hsa-miR-629	CLIP-seq
MIRT1496223	hsa-miR-651	CLIP-seq
MIRT1496224	hsa-miR-874	CLIP-seq
MIRT2397077	hsa-miR-3137	CLIP-seq
MIRT2397078	hsa-miR-4274	CLIP-seq
MIRT2397079	hsa-miR-4519	CLIP-seq
MIRT2397080	hsa-miR-622	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004177	Function	Aminopeptidase activity	TAS	9375790
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0016020	Component	Membrane	TAS	9375790
GO:0031225	Component	Anchored component of membrane	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070006	Function	Metalloaminopeptidase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070062	Component	Extracellular exosome	IDA	21082674

MIM	HGNC	e!Ensembl
300145	12823	ENSG00000122121

Protein

UniProt ID

O43895

Protein name

Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (Membrane-bound AmP) (mAmP) (X-Pro aminopeptidase 2)

Protein function

Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01321	Creatinase_N	54 → 191	Creatinase/Prolidase N-terminal domain	Domain
PF16189	Creatinase_N_2	195 → 361		Domain
PF00557	Peptidase_M24	362 → 576	Metallopeptidase family M24	Domain
PF16188	Peptidase_M24_C	584 → 648	C-terminal region of peptidase_M24	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary. {ECO:0000269|PubMed:9375790}.

Sequence

MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQ
MQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQ
AERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQL
VSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLS
ALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCV
QIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSK
EQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETIS
ASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYT
RVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQ
SNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNL
IDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWAS
VLVVSTLAILGWSV

Sequence length

674

Interactions

View interactions

	KEGG		Reactome
	Protein digestion and absorption		Post-translational modification: synthesis of GPI-anchored proteins

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Premature ovarian failure	Hypergonadotropic Ovarian Failure, X-Linked, Premature Ovarian Failure 1	rs587776535, rs71647804, rs137853320, rs606231206, rs121918655, rs121918656, rs606231207, rs606231208, rs80359775, rs397507719, rs200503569, rs587777267, rs730880018, rs587777268, rs587777269 View all (40 more)	25568306

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining
Angioedema	Associate	16175507, 20625347
Angioedemas Hereditary	Associate	25401373
Hemoglobin C Disease	Associate	17522242
Hypotension	Associate	23276181
Lymphatic Metastasis	Associate	31296901
Neoplasm Metastasis	Stimulate	31296901
Ovarian Diseases	Associate	39595984
Primary Ovarian Insufficiency	Associate	39595984
Prostatic Neoplasms	Inhibit	31296901

XPNPEP2 (X-prolyl aminopeptidase 2)