Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7482
Gene name Gene Name - the full gene name approved by the HGNC.
Wnt family member 2B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WNT2B
Synonyms (NCBI Gene) Gene synonyms aliases
WNT13
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs370244148 C>A,T Pathogenic Coding sequence variant, 5 prime UTR variant, synonymous variant, stop gained
rs879255420 C>T Pathogenic, uncertain-significance Coding sequence variant, stop gained
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT437828 hsa-miR-324-3p Luciferase reporter assay 23583221
MIRT437828 hsa-miR-324-3p Luciferase reporter assay 23583221
MIRT437828 hsa-miR-324-3p qRT-PCR 24367666
MIRT438036 hsa-miR-93-5p qRT-PCR 24367666
MIRT437828 hsa-miR-324-3p qRT-PCR 24367666
Transcription factors
Transcription factor Regulation Reference
GLI2 Activation 19360354
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002062 Process Chondrocyte differentiation IEP 15135146
GO:0002088 Process Lens development in camera-type eye ISS 16258938
GO:0005109 Function Frizzled binding IBA 21873635
GO:0005125 Function Cytokine activity IBA 21873635
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601968 12781 ENSG00000134245
Protein
UniProt ID Q93097
Protein name Protein Wnt-2b (Protein Wnt-13)
Protein function Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00110 wnt 74 380 wnt family Family
Tissue specificity TISSUE SPECIFICITY: Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal b
Sequence
Sequence length 391
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mTOR signaling pathway
Wnt signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Melanogenesis
Cushing syndrome
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  WNT ligand biogenesis and trafficking
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Hypertension Hypertensive disease rs13306026 30487518
Unknown
Disease term Disease name Evidence References Source
Ischemic Stroke Ischemic Stroke GWAS
Heart Failure Heart Failure GWAS
Associations from Text Mining
Disease Name Relationship Type References
Anophthalmia with pulmonary hypoplasia Associate 32799327
Anterior segment mesenchymal dysgenesis Associate 33526876
Autoimmune enteropathy Associate 33526876
Bipolar Disorder Associate 18606951
Breast Neoplasms Associate 33746192, 35660418
Carcinoma Basal Cell Stimulate 11348463
Carcinoma Hepatocellular Associate 33407720
Carcinoma Non Small Cell Lung Associate 30015869, 36102318
Carcinoma Renal Cell Associate 31486486
Carcinoma Squamous Cell Associate 29568882