Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7477
Gene name Gene Name - the full gene name approved by the HGNC.
Wnt family member 7B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WNT7B
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fat
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs1475762618 G>A Likely-pathogenic Missense variant, coding sequence variant
rs1569119395 G>A Pathogenic Coding sequence variant, stop gained
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016848 hsa-miR-335-5p Microarray 18185580
MIRT463899 hsa-miR-4698 HITS-CLIP 19536157
MIRT463898 hsa-miR-7113-5p HITS-CLIP 19536157
MIRT463897 hsa-miR-4685-5p HITS-CLIP 19536157
MIRT463896 hsa-miR-6837-5p HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
AR Activation 21741601
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development ISS
GO:0003338 Process Metanephros morphogenesis ISS
GO:0005109 Function Frizzled binding IBA 21873635
GO:0005125 Function Cytokine activity IBA 21873635
GO:0005515 Function Protein binding IPI 30026314
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601967 12787 ENSG00000188064
Protein
UniProt ID P56706
Protein name Protein Wnt-7b
Protein function Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta developm
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00110 wnt 40 349 wnt family Family
Tissue specificity TISSUE SPECIFICITY: Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly expressed in adult brain, lung and prostate.
Sequence
Sequence length 349
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mTOR signaling pathway
Wnt signaling pathway
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Melanogenesis
Cushing syndrome
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  WNT ligand biogenesis and trafficking
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Microphthalmos Microphthalmos rs794726862, rs1329285216
Syndromic microphthalmia ANOPHTHALMIA AND PULMONARY HYPOPLASIA rs786205873, rs104894464, rs786205874, rs104894465, rs387906701, rs1566623121, rs786205879, rs1566624472, rs397514463, rs1566623392, rs387907252, rs397518481, rs397518482, rs397518483, rs587776457
View all (19 more)
Unknown
Disease term Disease name Evidence References Source
Multiple Congenital Anomalies multiple congenital anomalies/dysmorphic syndrome GenCC
Diabetes Diabetes GWAS
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Myopia Myopia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Anophthalmia with pulmonary hypoplasia Associate 33934523
Arthritis Rheumatoid Associate 15972956
Axial osteomalacia Associate 32761137
Breast Neoplasms Associate 34457116, 9367869
Bursitis Associate 34111113
Carcinoma Stimulate 37108089
Carcinoma Hepatocellular Associate 19849855, 31277598
Carcinoma Renal Cell Associate 33804101
Carcinoma Squamous Cell Associate 28340578
Carcinoma Squamous Cell Stimulate 35850748