Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7474
Gene name Gene Name - the full gene name approved by the HGNC.
Wnt family member 5A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WNT5A
Synonyms (NCBI Gene) Gene synonyms aliases
hWNT5A
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p14.3
Summary Summary of gene provided in NCBI Entrez Gene.
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryog
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs78756487 AAAAAA>-,AA,AAA,AAAA,AAAAA,AAAAAAA,AAAAAAAA,AAAAAAAAA,AAAAAAAAAA,AAAAAAAAAAA Uncertain-significance, conflicting-interpretations-of-pathogenicity 3 prime UTR variant
rs181894008 G>A,C,T Uncertain-significance, conflicting-interpretations-of-pathogenicity, likely-benign Intron variant
rs387906663 A>G Pathogenic Missense variant, coding sequence variant
rs587784562 C>G Likely-pathogenic Missense variant, coding sequence variant
rs786200925 C>G Pathogenic Missense variant, coding sequence variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005162 hsa-miR-30a-5p pSILAC 18668040
MIRT020965 hsa-miR-155-5p Proteomics 20584899
MIRT021154 hsa-miR-186-5p Sequencing 20371350
MIRT005162 hsa-miR-30a-5p Proteomics;Other 18668040
MIRT030983 hsa-miR-21-5p Microarray 18591254
Transcription factors
Transcription factor Regulation Reference
CUX1 Activation 17227781;23359789
HOXB7 Activation 21183939
PITX2 Unknown 23250740
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000187 Process Activation of MAPK activity IDA 20034610
GO:0001736 Process Establishment of planar polarity IEA
GO:0001756 Process Somitogenesis IEA
GO:0001822 Process Kidney development IEA
GO:0001837 Process Epithelial to mesenchymal transition IEP 12841867
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
164975 12784 ENSG00000114251
Protein
UniProt ID P41221
Protein name Protein Wnt-5a
Protein function Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhib
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00110 wnt 71 380 wnt family Family
Tissue specificity TISSUE SPECIFICITY: Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protei
Sequence
Sequence length 380
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  mTOR signaling pathway
Wnt signaling pathway
Axon guidance
Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells
Melanogenesis
Cushing syndrome
Alzheimer disease
Pathways of neurodegeneration - multiple diseases
Human papillomavirus infection
Pathways in cancer
Proteoglycans in cancer
Basal cell carcinoma
Breast cancer
Hepatocellular carcinoma
Gastric cancer
  TCF dependent signaling in response to WNT
WNT ligand biogenesis and trafficking
Ca2+ pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Brachydactyly Brachydactyly rs121908949, rs28937580, rs121909082, rs104894122, rs863223289, rs863223290, rs104894121, rs1587657302, rs863223292, rs74315386, rs74315387, rs28936397, rs753691079, rs121909348, rs121917852
View all (22 more)
Cervical cancer cervical cancer rs28934571, rs121913482, rs121913483 25061499
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Developmental delay Global developmental delay rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291
View all (32 more)
Unknown
Disease term Disease name Evidence References Source
Ptosis Blepharoptosis, Ptosis ClinVar
Specific learning disorder Specific learning disability ClinVar
Robinow Syndrome autosomal dominant Robinow syndrome 1, autosomal dominant Robinow syndrome GenCC
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 35239776
Acute On Chronic Liver Failure Associate 38062395
Adenocarcinoma Associate 27084312, 28465645
Adenoma Stimulate 10507776
Adenoma Associate 27245242
Adenomatous Polyposis Coli Inhibit 17463182
Amyotrophic Lateral Sclerosis Associate 30924074
Aortic Dissection Associate 36959563
Arthritis Psoriatic Associate 35055107
Arthritis Rheumatoid Associate 10688908, 11315916, 33178184, 34211463