WARS1 (tryptophanyl-tRNA synthetase 1)

Gene
Gene SNPs Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7453
Gene name Gene Name - the full gene name approved by the HGNC.
Tryptophanyl-tRNA synthetase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WARS1
Synonyms (NCBI Gene) Gene synonyms aliases
GAMMA-2, HMN9, HMND9, IFI53, IFP53, NEDMSBA, WARS
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HMND9, NEDMSBA
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q32.2
Summary Summary of gene provided in NCBI Entrez Gene.
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first prot
SNPs SNP information provided by dbSNP.
Gene SNPs Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
SNP ID Visualize variation Clinical significance Consequence
rs770003315 T>A,C Pathogenic Coding sequence variant, missense variant
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene SNPs Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(29)
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001933 Process Negative regulation of protein phosphorylation IDA 22504299
GO:0004830 Function Tryptophan-tRNA ligase activity IBA 21873635
GO:0004830 Function Tryptophan-tRNA ligase activity IMP 28369220
GO:0004830 Function Tryptophan-tRNA ligase activity NAS 8496617
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene SNPs Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
191050 12729 ENSG00000140105
Protein
Gene SNPs Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P23381
Protein name Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Interferon-induced protein 53) (IFP53) (Tryptophanyl-tRNA synthetase) (TrpRS) (hWRS) [Cleaved into: T1-TrpRS; T2-TrpRS]
Protein function Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp). {ECO:0000269|PubMed:1373391, ECO:0000269|PubMed:1761529,
PDB 1O5T , 1R6T , 1R6U , 1ULH , 2AKE , 2AZX , 2DR2 , 2QUH , 2QUI , 2QUJ , 2QUK , 5UJI , 5UJJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00458 WHEP-TRS 12 → 64 WHEP-TRS domain Domain
PF00579 tRNA-synt_1b 151 → 443 tRNA synthetases class I (W and Y) Family
Sequence
Sequence length 471
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene SNPs Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Aminoacyl-tRNA biosynthesis   Cytosolic tRNA aminoacylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene SNPs Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Papillary thyroid carcinoma Papillary thyroid carcinoma rs751409106 28030816
Thyroid cancer Familial Nonmedullary Thyroid Cancer rs119486096, rs104894171, rs28933406, rs11554290, rs121913364, rs797044990, rs1564566774, rs200989342 28030816
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Distal Hereditary Motor Neuronopathy neuronopathy, distal hereditary motor, type 9 GenCC
Neuropathy distal hereditary motor neuropathy GenCC
Show/Hide Text Mining Associations (49)
Associations from Text Mining
Disease Name Relationship Type References
Adenoma Associate 37794510
Alzheimer Disease Associate 29485232
Arrhythmias Cardiac Associate 12747836
Atrial Fibrillation Associate 37967346
Breast Neoplasms Associate 9848077
Carcinoma Pancreatic Ductal Stimulate 33179081
Carcinoma Squamous Cell Associate 22546478
Cardiomyopathy Hypertrophic Associate 23741347
Cerebral Infarction Associate 39542148
Colorectal Neoplasms Associate 19383890, 25206290, 37794510