Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7431
Gene name	Vimentin
Gene symbol	VIM
Synonyms (NCBI Gene)	-
Chromosome	10
Chromosome location	10p13
Summary	This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, a

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1588736025	T>C	Likely-pathogenic	Coding sequence variant, missense variant

160

Show/Hide all (160)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004724	hsa-miR-124-3p	Luciferase reporter assayqRT-PCRWestern blot	19843643
MIRT004724	hsa-miR-124-3p	Luciferase reporter assayqRT-PCRWestern blot	19843643
MIRT004724	hsa-miR-124-3p	Luciferase reporter assayqRT-PCRWestern blot	19843643
MIRT004724	hsa-miR-124-3p	Luciferase reporter assayqRT-PCRWestern blot	19843643
MIRT005028	hsa-miR-17-3p	qRT-PCRWestern blot	19771525
MIRT007202	hsa-miR-30c-5p	Luciferase reporter assay	23224145
MIRT007202	hsa-miR-30c-5p	Luciferase reporter assay	23224145
MIRT021395	hsa-miR-9-5p	Western blot	20173740
MIRT021692	hsa-miR-138-5p	Reporter assay;Western blot;qRT-PCR;Other	21770894
MIRT004724	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT028543	hsa-miR-30a-5p	Proteomics	18668040
MIRT029436	hsa-miR-26b-5p	Microarray	19088304
MIRT031690	hsa-miR-16-5p	Proteomics	18668040
MIRT005028	hsa-miR-17-3p	Luciferase reporter assay	23418359
MIRT005028	hsa-miR-17-3p	CLASH	23622248
MIRT005028	hsa-miR-17-3p	CLASH	23622248
MIRT039936	hsa-miR-615-3p	CLASH	23622248
MIRT036001	hsa-miR-1301-3p	CLASH	23622248
MIRT052848	hsa-miR-3605-3p	CLASH	23622248
MIRT021692	hsa-miR-138-5p	qRT-PCRWestern blot	22766839
MIRT028543	hsa-miR-30a-5p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	24447545
MIRT054440	hsa-miR-378a-3p	Luciferase reporter assayqRT-PCRWestern blot	24555885
MIRT054440	hsa-miR-378a-3p	Luciferase reporter assayqRT-PCRWestern blot	24555885
MIRT054567	hsa-miR-506-3p	Luciferase reporter assayqRT-PCRWestern blot	23717581
MIRT054567	hsa-miR-506-3p	Luciferase reporter assayqRT-PCRWestern blot	23717581
MIRT054865	hsa-miR-204-5p	5.0	24280681
MIRT054440	hsa-miR-378a-3p	FlowqRT-PCRWestern blot	23135265
MIRT054440	hsa-miR-378a-3p	FlowqRT-PCRWestern blot	23135265
MIRT330235	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT565021	hsa-miR-4272	PAR-CLIP	20371350
MIRT565020	hsa-miR-8063	PAR-CLIP	20371350
MIRT565019	hsa-miR-4698	PAR-CLIP	20371350
MIRT330239	hsa-miR-4328	PAR-CLIP	20371350
MIRT330234	hsa-miR-875-3p	PAR-CLIP	20371350
MIRT565018	hsa-miR-3135b	PAR-CLIP	20371350
MIRT565017	hsa-miR-1287-5p	PAR-CLIP	20371350
MIRT330236	hsa-miR-3148	PAR-CLIP	20371350
MIRT565016	hsa-miR-6124	PAR-CLIP	20371350
MIRT565015	hsa-miR-5681b	PAR-CLIP	20371350
MIRT565014	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT565013	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT021692	hsa-miR-138-5p	Luciferase reporter assayqRT-PCRWestern blot	26796277
MIRT021692	hsa-miR-138-5p	Luciferase reporter assayqRT-PCRWestern blot	26796277
MIRT054567	hsa-miR-506-3p	Luciferase reporter assay	25230372
MIRT031365	hsa-miR-17-5p	Immunoprecipitaion (IP)Luciferase reporter assayqRT-PCRWestern blotting	32546833
MIRT004724	hsa-miR-124-3p	qRT-PCRWestern blotting	0
MIRT021692	hsa-miR-138-5p	qRT-PCRWestern blotting	0
MIRT031365	hsa-miR-17-5p	Flow cytometryqRT-PCR	33826035
MIRT734527	hsa-miR-143-3p	qRT-PCR	32449873
MIRT330235	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT565021	hsa-miR-4272	PAR-CLIP	20371350
MIRT565020	hsa-miR-8063	PAR-CLIP	20371350
MIRT565019	hsa-miR-4698	PAR-CLIP	20371350
MIRT330239	hsa-miR-4328	PAR-CLIP	20371350
MIRT330234	hsa-miR-875-3p	PAR-CLIP	20371350
MIRT565018	hsa-miR-3135b	PAR-CLIP	20371350
MIRT565017	hsa-miR-1287-5p	PAR-CLIP	20371350
MIRT330236	hsa-miR-3148	PAR-CLIP	20371350
MIRT565016	hsa-miR-6124	PAR-CLIP	20371350
MIRT565015	hsa-miR-5681b	PAR-CLIP	20371350
MIRT565014	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT565013	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT756432	hsa-miR-146a-5p	qRT-PCR	36415628
MIRT1555496	hsa-miR-122	CLIP-seq
MIRT1555497	hsa-miR-124	CLIP-seq
MIRT1555498	hsa-miR-1290	CLIP-seq
MIRT1555499	hsa-miR-137	CLIP-seq
MIRT1555500	hsa-miR-138	CLIP-seq
MIRT1555501	hsa-miR-21	CLIP-seq
MIRT1555502	hsa-miR-28-3p	CLIP-seq
MIRT1555503	hsa-miR-298	CLIP-seq
MIRT1555504	hsa-miR-30a	CLIP-seq
MIRT1555505	hsa-miR-30b	CLIP-seq
MIRT1555506	hsa-miR-30c	CLIP-seq
MIRT1555507	hsa-miR-30d	CLIP-seq
MIRT1555508	hsa-miR-30e	CLIP-seq
MIRT1555509	hsa-miR-3158-5p	CLIP-seq
MIRT1555510	hsa-miR-3167	CLIP-seq
MIRT1555511	hsa-miR-320b	CLIP-seq
MIRT1555512	hsa-miR-320c	CLIP-seq
MIRT1555513	hsa-miR-320d	CLIP-seq
MIRT1555514	hsa-miR-337-3p	CLIP-seq
MIRT1555515	hsa-miR-3607-3p	CLIP-seq
MIRT1555516	hsa-miR-3613-5p	CLIP-seq
MIRT1555517	hsa-miR-3653	CLIP-seq
MIRT1555518	hsa-miR-3658	CLIP-seq
MIRT1555519	hsa-miR-3659	CLIP-seq
MIRT1555520	hsa-miR-3686	CLIP-seq
MIRT1555521	hsa-miR-4263	CLIP-seq
MIRT1555522	hsa-miR-4418	CLIP-seq
MIRT1555523	hsa-miR-4429	CLIP-seq
MIRT1555524	hsa-miR-4490	CLIP-seq
MIRT1555525	hsa-miR-4511	CLIP-seq
MIRT1555526	hsa-miR-4652-3p	CLIP-seq
MIRT1555527	hsa-miR-4658	CLIP-seq
MIRT1555528	hsa-miR-4662a-3p	CLIP-seq
MIRT1555529	hsa-miR-4781-3p	CLIP-seq
MIRT1555530	hsa-miR-4793-3p	CLIP-seq
MIRT1555531	hsa-miR-4799-5p	CLIP-seq
MIRT1555532	hsa-miR-488	CLIP-seq
MIRT1555533	hsa-miR-506	CLIP-seq
MIRT1555534	hsa-miR-509-3-5p	CLIP-seq
MIRT1555535	hsa-miR-509-5p	CLIP-seq
MIRT1555536	hsa-miR-548a-3p	CLIP-seq
MIRT1555537	hsa-miR-548ae	CLIP-seq
MIRT1555538	hsa-miR-548aj	CLIP-seq
MIRT1555539	hsa-miR-548am	CLIP-seq
MIRT1555540	hsa-miR-548an	CLIP-seq
MIRT1555541	hsa-miR-548b-3p	CLIP-seq
MIRT1555542	hsa-miR-548e	CLIP-seq
MIRT1555543	hsa-miR-548f	CLIP-seq
MIRT1555544	hsa-miR-548x	CLIP-seq
MIRT1555545	hsa-miR-574-5p	CLIP-seq
MIRT1555546	hsa-miR-576-5p	CLIP-seq
MIRT1555547	hsa-miR-590-5p	CLIP-seq
MIRT1555548	hsa-miR-876-5p	CLIP-seq
MIRT1555496	hsa-miR-122	CLIP-seq
MIRT1557284	hsa-miR-548l	CLIP-seq
MIRT1557285	hsa-miR-548n	CLIP-seq
MIRT1557286	hsa-miR-643	CLIP-seq
MIRT1555499	hsa-miR-137	CLIP-seq
MIRT1555500	hsa-miR-138	CLIP-seq
MIRT1555519	hsa-miR-3659	CLIP-seq
MIRT1555524	hsa-miR-4490	CLIP-seq
MIRT1555527	hsa-miR-4658	CLIP-seq
MIRT1555530	hsa-miR-4793-3p	CLIP-seq
MIRT1555545	hsa-miR-574-5p	CLIP-seq
MIRT1555497	hsa-miR-124	CLIP-seq
MIRT2434664	hsa-miR-1246	CLIP-seq
MIRT1555498	hsa-miR-1290	CLIP-seq
MIRT1555499	hsa-miR-137	CLIP-seq
MIRT1555500	hsa-miR-138	CLIP-seq
MIRT1555503	hsa-miR-298	CLIP-seq
MIRT2434665	hsa-miR-3140-5p	CLIP-seq
MIRT1555509	hsa-miR-3158-5p	CLIP-seq
MIRT1555510	hsa-miR-3167	CLIP-seq
MIRT1555511	hsa-miR-320b	CLIP-seq
MIRT1555512	hsa-miR-320c	CLIP-seq
MIRT1555513	hsa-miR-320d	CLIP-seq
MIRT1555514	hsa-miR-337-3p	CLIP-seq
MIRT1555518	hsa-miR-3658	CLIP-seq
MIRT1555522	hsa-miR-4418	CLIP-seq
MIRT1555523	hsa-miR-4429	CLIP-seq
MIRT1555524	hsa-miR-4490	CLIP-seq
MIRT1555528	hsa-miR-4662a-3p	CLIP-seq
MIRT2434666	hsa-miR-4762-5p	CLIP-seq
MIRT1555530	hsa-miR-4793-3p	CLIP-seq
MIRT1555532	hsa-miR-488	CLIP-seq
MIRT1555533	hsa-miR-506	CLIP-seq
MIRT1555534	hsa-miR-509-3-5p	CLIP-seq
MIRT1555535	hsa-miR-509-5p	CLIP-seq
MIRT1555536	hsa-miR-548a-3p	CLIP-seq
MIRT1555537	hsa-miR-548ae	CLIP-seq
MIRT1555538	hsa-miR-548aj	CLIP-seq
MIRT1555539	hsa-miR-548am	CLIP-seq
MIRT1555540	hsa-miR-548an	CLIP-seq
MIRT1555542	hsa-miR-548e	CLIP-seq
MIRT1555543	hsa-miR-548f	CLIP-seq
MIRT1555544	hsa-miR-548x	CLIP-seq
MIRT1555548	hsa-miR-876-5p	CLIP-seq

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Transcription factor	Regulation	Reference
AR	Repression	18535113
CTNNB1	Activation	12750294
ERG	Activation	8895512
ETV4	Activation	8895512
HDGF	Activation	22247069
HIF1A	Activation	22295844
HIPK2	Repression	22236966
HOXA7	Activation	11742062
KLF8	Repression	20728449
PARP1	Activation	17720873
SOX2	Activation	20739473
SP1	Activation	12771217
TCF4	Activation	12750294
TRIM16	Repression	22009481
ZEB2	Activation	22227038
ZNF148	Repression	12771217;17663720
ZNF148	Unknown	20230874

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IEA
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579
GO:0005200	Function	Structural constituent of cytoskeleton	IBA
GO:0005200	Function	Structural constituent of cytoskeleton	IDA	11889032
GO:0005200	Function	Structural constituent of cytoskeleton	IEA
GO:0005212	Function	Structural constituent of eye lens	IEA
GO:0005515	Function	Protein binding	IPI	10852826, 11827972, 15161933, 15383276, 15671067, 15846844, 16169070, 16189514, 16361107, 16712842, 16923132, 17056548, 18811945, 18827015, 19386766, 19420356, 20603131, 20618440, 20729920, 20856200, 21699783, 21900206, 22300583, 22684479, 23112296, 24284321, 24940650, 25218743, 254
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	9150946, 15846844, 19386766, 20603131, 21914078, 27919618, 29496907
GO:0005737	Component	Cytoplasm	IEA
GO:0005777	Component	Peroxisome	IDA	17881773
GO:0005815	Component	Microtubule organizing center	TAS
GO:0005829	Component	Cytosol	IDA	21746880
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IDA	16769727
GO:0005856	Component	Cytoskeleton	IEA
GO:0005856	Component	Cytoskeleton	TAS	16130169
GO:0005882	Component	Intermediate filament	IBA
GO:0005882	Component	Intermediate filament	IDA	11889032, 29496907
GO:0005882	Component	Intermediate filament	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0010977	Process	Negative regulation of neuron projection development	IEA
GO:0014002	Process	Astrocyte development	IEA
GO:0016020	Component	Membrane	IEA
GO:0016363	Component	Nuclear matrix	IEA
GO:0019904	Function	Protein domain specific binding	IPI	21746880
GO:0030424	Component	Axon	IBA
GO:0031175	Process	Neuron projection development	IEA
GO:0031252	Component	Cell leading edge	IEA
GO:0032967	Process	Positive regulation of collagen biosynthetic process	IMP	21746880
GO:0042802	Function	Identical protein binding	IPI	15383276, 16169070, 17050693, 21900206, 22869704
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043488	Process	Regulation of mRNA stability	IMP	21746880
GO:0045103	Process	Intermediate filament-based process	IEA
GO:0045109	Process	Intermediate filament organization	IBA
GO:0045109	Process	Intermediate filament organization	IEA
GO:0045109	Process	Intermediate filament organization	ISS
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0045111	Component	Intermediate filament cytoskeleton	IEA
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0060020	Process	Bergmann glial cell differentiation	IEA
GO:0060090	Function	Molecular adaptor activity	EXP	22869704
GO:0070062	Component	Extracellular exosome	HDA	20458337, 21362503
GO:0070307	Process	Lens fiber cell development	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IMP	27812135
GO:0071225	Process	Cellular response to muramyl dipeptide	IMP	27812135
GO:0071346	Process	Cellular response to type II interferon	IEA
GO:0097110	Function	Scaffold protein binding	IPI	10852826
GO:1990254	Function	Keratin filament binding	IPI	15846844

MIM	HGNC	e!Ensembl
193060	12692	ENSG00000026025

P08670

Protein name

Vimentin

Protein function

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cel

PDB

1GK4 , 1GK6 , 1GK7 , 3G1E , 3KLT , 3S4R , 3SSU , 3SWK , 3TRT , 3UF1 , 4MCY , 4MCZ , 4MD0 , 4MD5 , 4MDI , 4MDJ , 4YPC , 4YV3 , 5WHF , 6ATF , 6ATI , 6BIR , 6YXK , 8RVE , 8TRQ , 8TRR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04732	Filament_head	6 → 101	Intermediate filament head (DNA binding) region	Family
PF00038	Filament	102 → 410	Intermediate filament protein	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines. {ECO:0000269|PubMed:2472876, EC

Sequence

MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGV
YATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDK
VRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAE
DIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEE
EIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSE
AANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQD
TIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSS
LNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE

Sequence length

466

Interactions

View interactions

	KEGG		Reactome
	Cytoskeleton in muscle cells Epstein-Barr virus infection MicroRNAs in cancer		Caspase-mediated cleavage of cytoskeletal proteins Striated Muscle Contraction Interleukin-4 and Interleukin-13 signaling Aggrephagy

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Cataract 30	Likely pathogenic; Pathogenic	rs864309690, rs121917775	RCV000488584 RCV000012983
Developmental cataract	Likely pathogenic; Pathogenic	rs864309690	RCV000203397
syndrome with premature-aging	Likely pathogenic	rs1588736025	RCV000853405

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs535331705	RCV005926763
Cervical cancer	Likely benign	rs535331705	RCV005926764
Clear cell carcinoma of kidney	Likely benign	rs535331705	RCV005926765
Lung cancer	Benign; Likely benign	rs368836644, rs535331705	RCV005927964 RCV005926767
Ovarian serous cystadenocarcinoma	Benign; Likely benign	rs368836644, rs535331705	RCV005927963 RCV005926766
Sarcoma	Benign	rs368836644	RCV005927962
Thymoma	Likely benign	rs147429387	RCV005907103
Thyroid cancer, nonmedullary, 1	Likely benign	rs147429387	RCV005907104
VIM-related disorder	Uncertain significance; Likely benign; Benign	rs766499205, rs138235394, rs531385322, rs149942621, rs145152785, rs144539901	RCV003412355 RCV003949396 RCV003948200 RCV003960636 RCV003943035 RCV004753142

Show/Hide Text Mining Associations (388)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acute Kidney Injury	Associate	24946133, 39954965
Adenocarcinoma	Associate	18212748, 22315367, 23264213, 26910219, 29179690, 29851704, 32727513, 34706517
Adenocarcinoma Mucinous	Associate	2173410, 30258209
Adenocarcinoma of Lung	Stimulate	25189096
Adenocarcinoma of Lung	Associate	31042721, 31043817, 31103348, 33825780, 34118147, 37424170, 38095634
Adenoma	Associate	27896617
Adenoma Oxyphilic	Associate	17683191, 25944973, 30116406
Adenoma Oxyphilic	Stimulate	18081436
Adrenal Cortex Neoplasms	Associate	10734233
Adrenal Gland Neoplasms	Associate	1693469
Adrenocortical Adenoma	Associate	40490431
Adrenocortical Carcinoma	Associate	1371262, 1693469
Aicardi Syndrome	Associate	1693469
Allergic Fungal Sinusitis	Associate	33251550
Alopecia Areata	Associate	29323127
Alzheimer Disease	Associate	37533101
Ameloblastoma	Associate	23303021
amyloidosis IX	Associate	23717685
Anemia	Associate	24946133
Aneuploidy	Associate	31646374
Antiphospholipid Syndrome	Stimulate	25301710
Aortic Aneurysm	Associate	23411750
Aortic Aneurysm Abdominal	Associate	21741794
Aortic Valve Insufficiency	Stimulate	37500054
Arrest of spermatogenesis	Inhibit	29479754
Arterio Arterial Fistula	Associate	33648532
Arthritis	Associate	18226202, 26160441, 7039525
Arthritis Rheumatoid	Associate	15020330, 17665451, 19248090, 22661643, 22674012, 23711220, 24850148, 26160441, 26268352, 31486697, 31819160, 32847506, 35904110, 39795892, 7039525
Arthritis Rheumatoid	Inhibit	16778393
Arthritis Rheumatoid	Stimulate	23418544
Ascites	Associate	33896831, 33921783
Astrocytoma	Associate	18226172, 26546435, 35511748
Atherosclerosis	Associate	34329656
Atrophy	Associate	21719789
Atypical Hemolytic Uremic Syndrome	Associate	37373158
Autoimmune Diseases	Associate	21209908, 38155185
Barrett Esophagus	Associate	22315367
Beta ketothiolase deficiency	Stimulate	25329121
Bicuspid Aortic Valve Disease	Associate	37108591
Biliary Atresia	Associate	30906331
Biliary Tract Neoplasms	Associate	27941621
Brain Injuries	Associate	24610929
Brain Neoplasms	Associate	29849822, 31649250, 32652895
Breast Neoplasms	Associate	12750294, 15353581, 16568083, 16941011, 17105822, 18536655, 18632620, 18844224, 19404921, 19695088, 20103682, 20551949, 21347235, 2153347, 21663619 View all (49 more)
Breast Neoplasms	Stimulate	23354842, 24427357, 39732179
Bronchiolitis Obliterans Syndrome	Associate	35185369
Burkitt Lymphoma	Associate	3258535
Calcinosis Cutis	Stimulate	12656306
Calcinosis Cutis	Associate	20303042, 21663619, 34881791, 36833374
Carcinogenesis	Associate	21491170, 28570699, 32575745
Carcinoma	Associate	16731596, 17460729, 21725518, 28534983, 29609569, 32777933
Carcinoma Adenoid Cystic	Associate	20032601, 2543695, 28545522
Carcinoma Adenosquamous	Associate	30258209
Carcinoma Basal Cell	Associate	1383350
Carcinoma Ductal	Stimulate	2173410
Carcinoma Ductal	Associate	7686566
Carcinoma Ductal Breast	Associate	1701960, 2153347, 24061457, 30359996
Carcinoma Embryonal	Associate	2419526
Carcinoma Endometrioid	Associate	16648864, 29851704, 37146405
Carcinoma Hepatocellular	Associate	1371262, 19140237, 24091674, 24313979, 24840636, 24890815, 25387077, 25753478, 25760690, 26516929, 26707238, 27468214, 28333958, 30453302, 31564085 View all (10 more)
Carcinoma Hepatocellular	Stimulate	30897324, 31931758
Carcinoma Mucoepidermoid	Associate	29900918
Carcinoma Non Small Cell Lung	Associate	18854838, 24662916, 24935588, 25502225, 25736925, 26783187, 27459545, 27489122, 28508744, 30562753, 31272261, 31438892, 33992097, 34455700, 35837990, 36924014, 37021822, 37664931 View all (3 more)
Carcinoma Ovarian Epithelial	Associate	19574770, 24816687, 25230372, 30846486, 31653136, 36814597
Carcinoma Pancreatic Ductal	Associate	21448168, 24797069, 25799022, 28475017, 31912090, 32467989, 33762591, 39682758, 40307206
Carcinoma Renal Cell	Associate	10233835, 11720477, 15953868, 17683191, 18327819, 20303042, 22766839, 23009866, 23658743, 24427344, 2456980, 24618616, 24625422, 28449664, 28638113 View all (17 more)
Carcinoma Signet Ring Cell	Associate	23573309, 34214117
Carcinoma Small Cell	Associate	12656306, 28834900
Carcinoma Squamous Cell	Associate	20498638, 22749497, 23397427, 23778524, 23999979, 25022397, 25695541, 26028085, 26864590, 28604655, 29637533, 31886179, 32727513, 34380795, 36012449
Carcinoma Squamous Cell	Stimulate	22850983
Carcinoma Transitional Cell	Associate	26640315
Cardiomyopathies	Associate	37982389
Cardiomyopathy Dilated	Stimulate	37852321
Cardiomyopathy Dilated	Associate	39442233
Cardiomyopathy Restrictive	Associate	35185369
Cataract	Associate	18618007, 28442786, 28450710, 37203095
Cataract congenital with microcornea or slight microphthalmia	Stimulate	23811327
Cerebral Infarction	Associate	35962388
Chanarin Dorfman Syndrome	Associate	33277516
Cholangiocarcinoma	Associate	15227745, 22664794, 23244128, 24816558, 24867095, 25644509, 28262738, 32020235, 35022330
Chondroblastoma	Stimulate	37344889
Chondrosarcoma	Stimulate	6192722
Chordoma	Associate	20461036
Choroid Plexus Neoplasms	Associate	28808307
Chronic Disease	Associate	38155185
Cirrhosis Familial	Associate	20513801
Clear cell metastatic renal cell carcinoma	Associate	15133478
Cleft Palate	Associate	32241273
Colitis Ulcerative	Associate	29027377
Colonic Neoplasms	Associate	36318684
Colorectal Neoplasms	Associate	15670151, 17325702, 19331162, 19528485, 21071512, 21747928, 22205702, 22251609, 22315367, 23748022, 25431258, 26662312, 27512995, 27742576, 28611349 View all (23 more)
Colorectal Neoplasms	Stimulate	18219106, 25738332, 27488539, 32086539
Communicable Diseases	Stimulate	30882463
Complement Component C1s Deficiency	Stimulate	30932019
Congenital contractural arachnodactyly	Associate	24969562
Coronary Artery Disease	Associate	29908844, 38049831
Craniopharyngioma	Associate	28487953
Crohn Disease	Associate	22684479, 22929019
Crohn Disease	Stimulate	29027377
Cystadenoma	Associate	36781954
Cystic Fibrosis	Associate	34657818
Death	Associate	19915524
Dendritic Cell Sarcoma Follicular	Associate	33277516
Dental Plaque	Associate	26932148, 36581839
Dermatofibrosarcoma	Associate	11598621
Desmoplastic Small Round Cell Tumor	Stimulate	23994981
Diabetes Mellitus	Stimulate	27411924
Diabetes Mellitus	Associate	36837510
Diabetes Mellitus Type 2	Associate	30372580, 38034011
Diabetic Nephropathies	Stimulate	36277688
Disease	Stimulate	19404921
Disease	Associate	27542211
Down Syndrome	Associate	32819430
Drug Related Side Effects and Adverse Reactions	Associate	25733818, 36032170
Endometrial Neoplasms	Associate	16648864, 21739232, 21851624, 22640183, 23318908, 23719407, 28618953, 31136293, 31233772, 35320951, 37146405, 37169340, 7540565
Endometriosis	Associate	11779588, 16750201, 31233772, 35379225, 36233009, 7540565
Endometriosis	Stimulate	29860279
Epidermolysis Bullosa Simplex	Associate	15556930
Epilepsy	Associate	37833937
Epstein Barr Virus Infections	Stimulate	8383238
Esophageal Neoplasms	Associate	25400779, 31186031, 33243974, 34160902
Esophageal Squamous Cell Carcinoma	Associate	20460738, 26095281, 32042337, 33248456, 35705994, 36085568
Fatty Liver	Stimulate	35916814
Fever	Inhibit	23002349
Fibroadenoma	Associate	19383306, 7686566
Fibroma	Associate	24552940, 34433104
Fibroma Desmoplastic	Associate	35174683
Fibrosis	Associate	21425431, 21719789, 24946133, 25149531, 25904701, 26076823, 28978905, 30598637, 30906331, 33860034, 36206048, 36242878, 36725885
Fibrosis	Stimulate	35916814
Flatfoot	Associate	35197508
Focal Cortical Dysplasia	Associate	37833937
Fractures Spontaneous	Associate	22315367
Gallbladder Neoplasms	Associate	37142981
Ganglion Cysts	Associate	25330907
Gastrointestinal Stromal Tumors	Associate	12296756, 29592983
Giant Axonal Neuropathy	Associate	19168853, 26700320
Glaucoma Open Angle	Associate	30899261, 32913388
Glioblastoma	Associate	12084347, 15720813, 19288188, 20383808, 21317457, 23826359, 28498803, 29864155, 31282108, 31649250, 33187334, 34080022, 35327982, 35807435, 35901345
Glioma	Associate	20167812, 21979894, 22076165, 25748242, 27179220, 27704357, 28498803, 29039584, 31968004, 34520391, 35511748, 6371809
Gliosarcoma	Associate	19241900, 26881579, 35381788, 9288640
Gliosis	Associate	28841900, 38180775
Glomerulonephritis	Associate	24946133
Glomerulonephritis IGA	Associate	24788122, 37170272
Glomerulosclerosis Focal Segmental	Associate	36529126
Glycogen Storage Disease Type II	Associate	25214719
Granular Cell Tumor	Associate	28057062
Granuloma	Associate	28978905
Granulosa Cell Tumor	Associate	3548408
HAIR AN syndrome	Stimulate	24113073
Hamartoma	Associate	3189513
Haspeslagh Fryns Muelenaere syndrome	Associate	10460780
Head and Neck Neoplasms	Associate	35737211
Hearing Loss Bilateral	Stimulate	24427357
Heart Diseases	Associate	32847506
Heart Failure	Associate	33874740
HELLP Syndrome	Associate	23640432
HELLP Syndrome	Stimulate	37013771
Hemangioblastoma	Associate	36510186
Hemangioendothelioma	Associate	27515856
Hepatitis B	Associate	23239149, 29849822
Hepatitis B Chronic	Stimulate	35916814
Hepatitis C	Stimulate	18932288
Hepatitis C	Associate	21281815
Hepatoblastoma	Associate	34685577
Hereditary Breast and Ovarian Cancer Syndrome	Stimulate	27956696
Hirschsprung Disease	Associate	33683746
Histiocytosis Non Langerhans Cell	Associate	24656263
HIV Infections	Associate	29425767
Huntington Disease	Associate	36437609
Hypersensitivity Immediate	Associate	21491170
Hypertension	Associate	23640432
Hypertension Pulmonary	Associate	7508683
Hypertension Resistant to Conventional Therapy	Stimulate	11337362
Hypoxia	Associate	23050024, 25860915, 31428643, 37013771, 37713813
Hypoxia	Stimulate	25096400, 25501705, 26433470, 29218693, 35059742, 35603730
Hypoxia	Inhibit	34624938
Hypoxia Brain	Stimulate	23185433
Hypoxia Brain	Associate	24500281
Idiopathic Pulmonary Fibrosis	Associate	28754682, 7686566
Idiopathic subglottic tracheal stenosis	Associate	34111429
Infarction Middle Cerebral Artery	Associate	25448402
Infections	Associate	28566373, 29425767, 35197508
Inflammation	Associate	22367194, 22929019, 25214719, 25306868, 26076823, 26640315, 29027377, 30882463, 31165469, 35197508, 37424170, 38454689, 40307206
Inflammatory Bowel Diseases	Associate	23347191
Inflammatory Breast Neoplasms	Associate	26207636
Intervertebral Disc Degeneration	Associate	35409356
Intestinal Pseudo Obstruction	Associate	17105822
Job Syndrome	Stimulate	29985426
Keloid	Associate	22509836
Keratoconus	Associate	23727491
Kidney Cortex Necrosis	Associate	15509197
Kidney Diseases	Associate	24040439, 24475278, 25306868, 25904701
Kidney Failure Chronic	Stimulate	25547164
Kidney Neoplasms	Associate	10233835, 25149531
Kidney Tubular Necrosis Acute	Associate	21281815
Leukemia	Associate	20139074, 2599104, 3888314
Leukemia Lymphocytic Chronic B Cell	Associate	18223168, 21209908, 3258535
Leukemia Lymphoma Adult T Cell	Associate	25448402
Leukemia Megakaryoblastic Acute	Inhibit	3888314
Leukemia Myeloid	Associate	9247605
Leukemia Myeloid Acute	Associate	20139074, 25149531, 28106537, 29925392, 3888314
Leukemia Myelomonocytic Acute	Stimulate	3888314
Leukemia Prolymphocytic T Cell	Associate	27097566
Leukemia Promyelocytic Acute	Inhibit	3888314
Leukemia T Cell	Stimulate	2293664
Limb girdle muscular dystrophy type 2A	Associate	22443334
Liver Cirrhosis	Associate	35916814
Liver Diseases	Stimulate	35916814
Liver Failure	Stimulate	35916814
Lung Diseases	Associate	26568007, 27157519
Lung Diseases	Stimulate	32396269
Lung Diseases Interstitial	Associate	37266432
Lung Neoplasms	Associate	17720873, 25340791, 28121350, 28487957, 28677797, 29467444, 31646374, 31847480, 33416106, 35189561, 35627232, 35766227, 37340370, 39542246
Lung Neoplasms	Stimulate	27363026
Lupus Erythematosus Systemic	Associate	25306868
Lupus Nephritis	Associate	25306868
Lymphatic Diseases	Associate	20460738
Lymphatic Metastasis	Associate	18327819, 19140237, 23244128, 23751022, 24816558, 26028085, 26045832, 27966589, 28487957, 30359996, 35320951, 36082807, 36318684
Lymphatic Metastasis	Stimulate	20460738, 28570699, 33035412, 33789624
Lymphatic Metastasis	Inhibit	25724181
Lymphoma Follicular	Inhibit	3258535
Lymphoma Large Cell Anaplastic	Associate	1711289
Lymphoma Non Hodgkin	Associate	1711289, 22315367
Medulloblastoma	Associate	16309171
Melanoma	Associate	15510611, 20856146, 24392146, 26022451, 26894856, 27846383, 33078756, 33593721
Melanoma	Stimulate	37481560
Meningeal Carcinomatosis	Associate	19661359
Meningioma	Associate	15133478, 20160375, 20169076, 2422220, 25413266, 28191624, 32858607
Meningioma familial	Associate	32858607
Meningitis Bacterial	Associate	22536447
Mental Disorders	Associate	23272063
Mesothelioma Malignant	Associate	25400801, 30111297
Metabolic Syndrome	Associate	37033267
Metaplasia	Associate	17185354
Mitochondrial Diseases	Associate	26076823
Mohr Tranebjaerg syndrome	Stimulate	33390772
Mouth Diseases	Associate	34706517
Mouth Neoplasms	Associate	32495878
Muscular Dystrophy Duchenne	Associate	12619170
Myocardial Infarction	Stimulate	37798364
Myopathies Nemaline	Associate	7608737
Myopathies Structural Congenital	Associate	7608737
Myositis Inclusion Body	Associate	15146016
Nasal Polyps	Associate	28804222, 31839751
Nasal Polyps	Stimulate	34953475
Nasopharyngeal Carcinoma	Stimulate	27108809
Nasopharyngeal Carcinoma	Associate	28355254, 30338802, 34841830, 34894048, 34906623, 38191501
Necrosis	Associate	2173410
Neointima	Associate	28978905
Neoplasm Invasiveness	Associate	18536655, 1987760, 21491170, 23751022, 26095281
Neoplasm Invasiveness	Stimulate	30932019
Neoplasm Metastasis	Associate	12656306, 18383865, 19331162, 20097873, 20460738, 21242333, 21670854, 23751022, 24091674, 25230372, 25340791, 25431258, 25894377, 25990368, 26045832 View all (35 more)
Neoplasm Metastasis	Stimulate	17296934, 19404921, 22388757, 23717685, 31947504, 33789624, 37340370
Neoplasm Metastasis	Inhibit	24059685, 35320951
Neoplasms	Associate	10226840, 10233835, 10705399, 10777586, 10885653, 11231493, 11300941, 11337362, 11395375, 11407827, 12084347, 12296765, 12368191, 12656306, 12683899 View all (253 more)
Neoplasms	Stimulate	19695088, 25329121, 25413266, 25973113, 28802099, 30244221, 31040369, 31912090, 32668208, 34090218, 37553013
Neoplasms	Inhibit	26045824, 32426802
Neoplasms Basal Cell	Associate	26567912
Neoplasms Ductal Lobular and Medullary	Associate	38046195
Neoplasms Germ Cell and Embryonal	Associate	29479754
Neoplasms Glandular and Epithelial	Associate	15888043, 18081436, 22236966, 24061457
Neoplasms Neuroepithelial	Associate	17057885
Neoplasms Squamous Cell	Associate	26571236
Neoplastic Cells Circulating	Associate	35241536
Nephritis Interstitial	Associate	25306868
Nerve Degeneration	Associate	15556930, 29641463, 40479066
Neurilemmoma	Associate	24077273
Neuroblastoma	Inhibit	11501497
Neuroblastoma	Associate	18230156, 19216736, 20813048, 27866306, 35531888
Neuroectodermal Tumors Primitive	Associate	22076165
Neuroendocrine Tumors	Associate	33789624, 37033229
Neurologic Manifestations	Associate	40479066
Niemann Pick Disease Type C	Associate	28841900
NOG Related Symphalangism Spectrum Disorder	Associate	26640315
Non alcoholic Fatty Liver Disease	Associate	21656912
Non Muscle Invasive Bladder Neoplasms	Associate	32758253
Non Muscle Invasive Bladder Neoplasms	Stimulate	36594099
O'Donnell Pappas syndrome	Associate	38634365
Obesity	Associate	21242333, 36837510
Oculocutaneous albinism type 2	Associate	21491170, 28611349
Oligodendroglioma	Associate	35511748
Oncocytoma renal	Stimulate	11337362
Oncocytoma renal	Associate	18081436, 21323945, 21590491
Oral Submucous Fibrosis	Associate	37147960
Osteoarthritis	Associate	14697681, 17643325, 37855367
Osteoma Osteoid	Associate	38008425
Osteosarcoma	Associate	24475253, 29048621
Ovarian Diseases	Associate	34770931
Ovarian Neoplasms	Associate	19028702, 19159301, 21131918, 24681739, 25096996, 25894377, 27322682, 30058681, 30756366, 32547317, 34711431, 34770931, 35379775, 3548408, 35953860, 7678716, 9266754 View all (2 more)
Pancreatic Neoplasms	Associate	1372155, 20589377, 21448168, 23940742, 25278713, 26247532, 30158928, 31688603, 32090981, 35475918, 36788090, 40315568
Papillomavirus Infections	Associate	32794417
Parathyroid Diseases	Associate	34706517
Parkinson Disease	Associate	40479066
Pelvic Organ Prolapse	Associate	25923074
Periodontitis	Stimulate	34597477
Periodontitis	Associate	36438900
Peritonitis	Associate	19331162
Pheochromocytoma	Associate	40490431
Phyllodes Tumor	Associate	7686566
Pituitary ACTH Hypersecretion	Inhibit	30722035
Pituitary Neoplasms	Associate	26617803
Placenta Diseases	Associate	23640432
Plaque Atherosclerotic	Associate	2190471
Pleural Diseases	Associate	26464642
Pleural Effusion	Associate	17914498
Pleural Effusion Malignant	Associate	17914498
Polycystic Kidney Autosomal Dominant	Associate	19259356
Poroma	Associate	18212539
Pre Eclampsia	Associate	37013771
Precancerous Conditions	Associate	32794417
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Stimulate	37354622
Prostatic Hyperplasia	Associate	33031138
Prostatic Intraepithelial Neoplasia	Associate	1987760
Prostatic Neoplasms	Associate	18383865, 19001380, 19578386, 21677876, 23717685, 24122992, 24615813, 25030902, 26847404, 26923772, 29164579, 29300772, 30199553, 30531834, 31786880 View all (6 more)
Prostatic Neoplasms Castration Resistant	Associate	37476073
Prostatitis	Stimulate	27956696
Prostatitis	Associate	33525953, 36232736, 8937470
Proteinuria	Associate	25904701
Pseudomyxoma Peritonei	Associate	17031402
Psoriasis	Associate	26617803
Psychological Distress	Associate	37855367
Pterygium	Associate	24825356, 36242878
Pulmonary Disease Chronic Obstructive	Associate	25600626, 25706093, 26346976, 29068985, 29581578, 36420658
Pulmonary Disease Chronic Obstructive	Stimulate	25745049, 31427443, 34210319
Pulmonary Fibrosis	Associate	35532073
Pyelonephritis Xanthogranulomatous	Associate	28978905
Pyruvate Carboxylase Deficiency Disease	Associate	36788090
Radiation Injuries	Associate	33785878
Rectal Neoplasms	Associate	31696471, 36221784
Renal cell carcinoma 1	Stimulate	25609022
Renal Insufficiency Chronic	Associate	15509197, 25904701
Rhabdoid Tumor	Associate	15605995, 17227108
Rhabdomyosarcoma	Associate	20701800, 7524332, 8160781
Rhabdomyosarcoma Embryonal	Associate	20701800
Rhegmatogenous Retinal Detachment Autosomal Dominant	Associate	29641463
Rheumatic Heart Disease	Inhibit	28121998
Rufous oculocutaneous albinism	Associate	21491170
Salivary Gland Neoplasms	Associate	18176708, 39201484
Sarcoidosis	Associate	17975675, 26585430
Sarcoidosis Pulmonary	Associate	26585430
Sarcoma	Associate	12946229, 21390241, 21983934, 24448245, 8813967
Sarcoma Alveolar Soft Part	Associate	24427344
Sarcoma Ewing	Associate	16100468, 33719644
Seminoma	Associate	2412445, 27461702
Sertoli Cell Tumor	Associate	37189109
Sexual Dysfunction Physiological	Associate	26448925
Sezary Syndrome	Associate	16365461, 16418328
Sick Sinus Syndrome	Associate	1701960
Simpson Golabi Behmel syndrome	Stimulate	39542246
Sjogren's Syndrome	Associate	31165469
Small Cell Lung Carcinoma	Associate	11395375, 28719656
Solitary Fibrous Tumors	Associate	11598621, 9372338
spaceflight induced visual impairment	Associate	34714361
Spastic ataxia Charlevoix Saguenay type	Associate	34769152
Spondylarthritis	Associate	22972410
Spondylitis Ankylosing	Associate	23280360, 38634365
Squamous Cell Carcinoma of Head and Neck	Associate	18327819, 19915524, 20497865, 21670854, 23527004, 25047112, 25607384, 25854342, 26018309, 26040981, 26045832, 27966589, 28072763, 28319306, 28499703 View all (16 more)
Squamous Cell Carcinoma of Head and Neck	Stimulate	27259998
Stomach Neoplasms	Associate	19528485, 22315367, 23504025, 23751022, 24815301, 25144746, 25441488, 26176983, 26617790, 27448976, 30646925, 30700111, 30720114, 30974047, 31773716 View all (12 more)
Stomach Neoplasms	Inhibit	28983895
Synovitis Pigmented Villonodular	Associate	6207733
Tarlov Cysts	Associate	33789624
Tertiary Lymphoid Structures	Stimulate	19404921, 24709997
Tertiary Lymphoid Structures	Associate	20460738, 28112378, 28759954
Testicular Germ Cell Tumor	Associate	20977544, 35575252
Thalassemia Beta+ Silent Allele	Associate	39795892
Thrombosis	Associate	24091674, 25301710
Thyroid Cancer Papillary	Associate	17296934, 27833974
Thyroid Carcinoma Anaplastic	Associate	35491899
Thyroid Neoplasms	Associate	17296934, 25329121, 32698816, 33333840, 3546391, 39179334
Tissue Adhesions	Associate	33860034
Tn Syndrome	Stimulate	24606439
Tooth Erosion	Stimulate	22674012, 26337028
Triple Negative Breast Neoplasms	Stimulate	23354842
Triple Negative Breast Neoplasms	Associate	26759246, 28802099, 30338806, 30602372, 32244385, 32266539, 35163593, 36769215, 36937603, 37217473, 38155378
Tuberous Sclerosis	Associate	18226172, 24832166
Tuberous Sclerosis 1	Associate	25149531
Ureteral Obstruction	Stimulate	34943853
Urethral Neoplasms	Associate	36032170
Urinary Bladder Diseases	Associate	26640315
Urinary Bladder Neoplasms	Associate	19252475, 23056278, 24325461, 24571540, 24856504, 26640315, 26988652, 27367032, 27402302, 28218359, 29517839, 32758253, 34332039, 34565009, 36594099, 37461061 View all (1 more)
Uterine Cervical Neoplasms	Associate	21491170, 24058594, 27034707, 28252165, 29989651, 32373949, 36834676
Uterine Cervicitis	Associate	35144405
Uterine Neoplasms	Stimulate	24681739
Uveal melanoma	Associate	9546344
Vascular Diseases	Associate	25323856
Virus Diseases	Associate	27423069
Vitreoretinopathy Proliferative	Stimulate	38180775

VIM (vimentin)