Gene Gene information from NCBI Gene database.
Entrez ID 7417
Gene name Voltage dependent anion channel 2
Gene symbol VDAC2
Synonyms (NCBI Gene)
POR
Chromosome 10
Chromosome location 10q22.2
Summary This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in
miRNA miRNA information provided by mirtarbase database.
250
miRTarBase ID miRNA Experiments Reference
MIRT021858 hsa-miR-132-3p Microarray 17612493
MIRT048258 hsa-miR-196a-5p CLASH 23622248
MIRT046413 hsa-miR-15b-5p CLASH 23622248
MIRT044736 hsa-miR-320a CLASH 23622248
MIRT615410 hsa-miR-4512 HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
41
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001669 Component Acrosomal vesicle IDA 23355646
GO:0005244 Function Voltage-gated monoatomic ion channel activity IDA 8420959
GO:0005515 Function Protein binding IPI 15082785, 17500595, 23355646, 26618866, 29128334, 30021884, 32814053, 35156780, 35271311, 36012204
GO:0005524 Function ATP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
193245 12672 ENSG00000165637
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P45880
Protein name Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)
Protein function Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation
PDB 9EIH , 9EII , 9EIJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01459 Porin_3 14 287 Eukaryotic porin Family
Tissue specificity TISSUE SPECIFICITY: Expressed in erythrocytes (at protein level) (PubMed:27641616). Expressed in all tissues examined (PubMed:8420959). {ECO:0000269|PubMed:27641616, ECO:0000269|PubMed:8420959}.
Sequence
Sequence length 294
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Calcium signaling pathway
cGMP-PKG signaling pathway
Ferroptosis
Necroptosis
Cellular senescence
Neutrophil extracellular trap formation
NOD-like receptor signaling pathway
Cholesterol metabolism
Alzheimer disease
Parkinson disease
Huntington disease
Spinocerebellar ataxia
Prion disease
Pathways of neurodegeneration - multiple diseases
Human T-cell leukemia virus 1 infection
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy
  Ub-specific processing proteases
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Severe combined immunodeficiency disease Uncertain significance rs1240341712 RCV003326051
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 37714937
Asthenozoospermia Associate 20809416
Carcinoma Hepatocellular Associate 36028814
Carcinoma Renal Cell Associate 36445063
Cardiomyopathies Associate 37416771
Cardiomyopathy Dilated Associate 27892527
Endometrial Neoplasms Associate 32829673
Glaucoma Associate 30899261
Heart Diseases Associate 37416771
Infertility Associate 27806320