Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7371
Gene name Gene Name - the full gene name approved by the HGNC.
Uridine-cytidine kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
UCK2
Synonyms (NCBI Gene) Gene synonyms aliases
TSA903, UK, UMPK
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q24.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025567 hsa-miR-34a-5p Proteomics 21566225
MIRT032462 hsa-let-7b-5p Proteomics 18668040
MIRT044088 hsa-miR-361-5p CLASH 23622248
MIRT553086 hsa-miR-6835-3p PAR-CLIP 21572407
MIRT553087 hsa-miR-4422 PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004849 Function Uridine kinase activity IEA
GO:0005524 Function ATP binding IEA
GO:0005575 Component Cellular_component ND
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005829 Component Cytosol IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609329 12562 ENSG00000143179
Protein
UniProt ID Q9BZX2
Protein name Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2)
Protein function Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702, PubMed:11494055). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphat
PDB 1UDW , 1UEI , 1UEJ , 1UFQ , 1UJ2 , 1XRJ , 6N53 , 6N54 , 6N55 , 6PWZ , 7SQL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00485 PRK 22 217 Phosphoribulokinase / Uridine kinase family Domain
Tissue specificity TISSUE SPECIFICITY: According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific. {ECO:0000269|PubMed:8812458}.
Sequence
Sequence length 261
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism
  Pyrimidine salvage
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
27602772
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 24763052
Unknown
Disease term Disease name Evidence References Source
Testicular Germ Cell Tumor Testicular Germ Cell Tumor GWAS
Multiple Sclerosis Multiple Sclerosis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Stimulate 30304569, 36447138
Carcinoma Hepatocellular Associate 32382568, 33188160, 33540684, 34523732, 38025761
Drug Related Side Effects and Adverse Reactions Associate 12149149, 27239701
Endometrial Neoplasms Associate 32894095
Heart Failure Associate 35128826
Lung Neoplasms Stimulate 31278886
Lung Neoplasms Associate 32638267
Neoplasms Associate 12149149, 32638267, 36447138
Neuroblastoma Associate 27239701
Pancreatic Neoplasms Associate 12149149