Gene Gene information from NCBI Gene database.
Entrez ID 7371
Gene name Uridine-cytidine kinase 2
Gene symbol UCK2
Synonyms (NCBI Gene)
TSA903UKUMPK
Chromosome 1
Chromosome location 1q24.1
Summary This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
miRNA miRNA information provided by mirtarbase database.
689
miRTarBase ID miRNA Experiments Reference
MIRT025567 hsa-miR-34a-5p Proteomics 21566225
MIRT032462 hsa-let-7b-5p Proteomics 18668040
MIRT044088 hsa-miR-361-5p CLASH 23622248
MIRT553086 hsa-miR-6835-3p PAR-CLIP 21572407
MIRT553087 hsa-miR-4422 PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004849 Function Uridine kinase activity IBA
GO:0004849 Function Uridine kinase activity IDA 11306702, 27239701
GO:0004849 Function Uridine kinase activity IEA
GO:0005524 Function ATP binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609329 12562 ENSG00000143179
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BZX2
Protein name Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2)
Protein function Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702, PubMed:11494055). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphat
PDB 1UDW , 1UEI , 1UEJ , 1UFQ , 1UJ2 , 1XRJ , 6N53 , 6N54 , 6N55 , 6PWZ , 7SQL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00485 PRK 22 217 Phosphoribulokinase / Uridine kinase family Domain
Tissue specificity TISSUE SPECIFICITY: According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific. {ECO:0000269|PubMed:8812458}.
Sequence
Sequence length 261
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism
  Pyrimidine salvage