UGT2B17 (UDP glucuronosyltransferase family 2 member B17)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7367
Gene name Gene Name - the full gene name approved by the HGNC.
UDP glucuronosyltransferase family 2 member B17
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
UGT2B17
Synonyms (NCBI Gene) Gene synonyms aliases
BMND12, UDPGT2B17
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and l
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(17)
miRTarBase ID miRNA Experiments Reference
MIRT017924 hsa-miR-335-5p Microarray 18185580
MIRT021574 hsa-miR-142-3p Microarray 17612493
MIRT732037 hsa-miR-409-3p PC3M 26385605
MIRT732037 hsa-miR-409-3p PC3M 26385605
MIRT1473636 hsa-miR-133a CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(4)
Transcription factor Regulation Reference
CDX2 Unknown 20070244
FOXA1 Activation 20628005
HNF1A Activation 11191885
PBX2 Unknown 12065766
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0001972 Function Retinoic acid binding IDA 20308471
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0008194 Function UDP-glycosyltransferase activity IBA 21873635
GO:0008202 Process Steroid metabolic process TAS 8798464
GO:0008210 Process Estrogen metabolic process IDA 18719240
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601903 12547 ENSG00000197888
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O75795
Protein name UDP-glucuronosyltransferase 2B17 (UDPGT 2B17) (UGT2B17) (EC 2.4.1.17) (C19-steroid-specific UDP-glucuronosyltransferase) (C19-steroid-specific UDPGT)
Protein function UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either th
PDB 7YAN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00201 UDPGT 24 → 527 UDP-glucoronosyl and UDP-glucosyl transferase Family
Tissue specificity TISSUE SPECIFICITY: Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate. {ECO:0000269|PubMed:8798464}.
Sequence
Sequence length 530
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Steroid hormone biosynthesis
Retinol metabolism
Porphyrin metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Biosynthesis of cofactors
Bile secretion
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation 		  Glucuronidation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (4)
Causal
Disease term Disease name dbSNP ID References
Adenocarcinoma Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular rs121913530, rs886039394, rs121913474 17416778
Carcinoma Carcinoma, Cribriform, Carcinoma, Granular Cell rs121912654, rs555607708, rs786202962, rs1564055259 17416778
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 17416778
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17826523
Show/Hide Text Mining Associations (34)
Associations from Text Mining
Disease Name Relationship Type References
Acute Disease Associate 26367234
Adenocarcinoma Associate 31164411
Arthritis Associate 40264209
Autoimmune Diseases Associate 36347965
Breast Neoplasms Associate 33503040
Carcinoma Squamous Cell Associate 31164411
Colorectal Neoplasms Inhibit 23575887
Death Associate 23169782
Disease Associate 32047296
Endometrial Neoplasms Stimulate 20554747