UGT2B17 (UDP glucuronosyltransferase family 2 member B17)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 7367
Gene name UDP glucuronosyltransferase family 2 member B17
Gene symbol UGT2B17
Synonyms (NCBI Gene)
BMND12UDPGT2B17
Chromosome 4
Chromosome location 4q13.2
Summary This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and l
miRNA miRNA information provided by mirtarbase database.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT017924 hsa-miR-335-5p Microarray 18185580
MIRT021574 hsa-miR-142-3p Microarray 17612493
MIRT732037 hsa-miR-409-3p PC3M 26385605
MIRT732037 hsa-miR-409-3p PC3M 26385605
MIRT1473636 hsa-miR-133a CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
4
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
CDX2 Unknown 20070244
FOXA1 Activation 20628005
HNF1A Activation 11191885
PBX2 Unknown 12065766
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001972 Function Retinoic acid binding IDA 20308471
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0005789 Component Endoplasmic reticulum membrane TAS
GO:0006629 Process Lipid metabolic process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601903 12547 ENSG00000197888
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75795
Protein name UDP-glucuronosyltransferase 2B17 (UDPGT 2B17) (UGT2B17) (EC 2.4.1.17) (C19-steroid-specific UDP-glucuronosyltransferase) (C19-steroid-specific UDPGT)
Protein function UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either th
PDB 7YAN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00201 UDPGT 24 → 527 UDP-glucoronosyl and UDP-glucosyl transferase Family
Tissue specificity TISSUE SPECIFICITY: Expressed in various tissues including the liver, kidney, testis, uterus, placenta, mammary gland, adrenal gland, skin and prostate. {ECO:0000269|PubMed:8798464}.
Sequence
Sequence length 530
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Steroid hormone biosynthesis
Retinol metabolism
Porphyrin metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Biosynthesis of cofactors
Bile secretion
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation 		  Glucuronidation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
UGT2B17-related disorder Benign; Likely benign rs34664906, rs746870450, rs28374627, rs13102139, rs143522336, rs369617587, rs79242783, rs150774462, rs72551385, rs72551386, rs143800988, rs369061334 RCV003974519
RCV003904640
RCV003979628
RCV003974303
RCV003931593
RCV003939527
RCV003939363
RCV003971569
RCV003960858
RCV003905969
RCV003948302
RCV003955899
Show/Hide Text Mining Associations (34)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Disease Associate 26367234
Adenocarcinoma Associate 31164411
Arthritis Associate 40264209
Autoimmune Diseases Associate 36347965
Breast Neoplasms Associate 33503040
Carcinoma Squamous Cell Associate 31164411
Colorectal Neoplasms Inhibit 23575887
Death Associate 23169782
Disease Associate 32047296
Endometrial Neoplasms Stimulate 20554747