UGT2B10 (UDP glucuronosyltransferase family 2 member B10)

Gene

• Entrez ID: 7365
• Gene name: UDP glucuronosyltransferase family 2 member B10
• Gene symbol: UGT2B10
• Synonyms (NCBI Gene): UDPGT2B10
• Chromosome: 4
• Chromosome location: 4q13.2

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs61750900	G>A,T	Drug-response	Intron variant, missense variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT551989	hsa-miR-890	PAR-CLIP	21572407
MIRT551988	hsa-miR-501-3p	PAR-CLIP	21572407
MIRT551987	hsa-miR-502-3p	PAR-CLIP	21572407
MIRT551986	hsa-miR-5690	PAR-CLIP	21572407
MIRT551985	hsa-miR-6804-3p	PAR-CLIP	21572407
MIRT551984	hsa-miR-4281	PAR-CLIP	21572407
MIRT551982	hsa-miR-7977	PAR-CLIP	21572407
MIRT551983	hsa-miR-500a-3p	PAR-CLIP	21572407
MIRT551981	hsa-miR-133a-3p	PAR-CLIP	21572407
MIRT735965	hsa-miR-485-5p	Luciferase reporter assay, qRT-PCR	31554697
MIRT551989	hsa-miR-890	PAR-CLIP	21572407
MIRT551988	hsa-miR-501-3p	PAR-CLIP	21572407
MIRT551987	hsa-miR-502-3p	PAR-CLIP	21572407
MIRT551986	hsa-miR-5690	PAR-CLIP	21572407
MIRT551985	hsa-miR-6804-3p	PAR-CLIP	21572407
MIRT551984	hsa-miR-4281	PAR-CLIP	21572407
MIRT551982	hsa-miR-7977	PAR-CLIP	21572407
MIRT551983	hsa-miR-500a-3p	PAR-CLIP	21572407
MIRT551981	hsa-miR-133a-3p	PAR-CLIP	21572407
MIRT1473622	hsa-miR-216b	CLIP-seq
MIRT1473623	hsa-miR-3921	CLIP-seq
MIRT1473624	hsa-miR-4255	CLIP-seq
MIRT1473625	hsa-miR-4446-5p	CLIP-seq
MIRT1473626	hsa-miR-4653-5p	CLIP-seq
MIRT1473627	hsa-miR-4755-5p	CLIP-seq
MIRT1473628	hsa-miR-4766-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006629	Process	Lipid metabolic process	TAS	8333863
GO:0008194	Function	UDP-glycosyltransferase activity	IBA	21873635
GO:0015020	Function	Glucuronosyltransferase activity	IDA	8333863
GO:0016021	Component	Integral component of membrane	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IBA	21873635

Other IDs

• MIM: 600070
• HGNC: 12544
• e!Ensembl: ENSG00000109181

Protein

• UniProt ID: P36537
• Protein name: UDP-glucuronosyltransferase 2B10 (UDPGT 2B10) (EC 2.4.1.17)
• Protein function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
• PDB: 7YF5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00201	UDPGT	23 → 525	UDP-glucoronosyl and UDP-glucosyl transferase	Family

• Sequence:

  MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
  ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
  IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
  RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
  RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
  NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
  LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
  STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
  NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD

• Sequence length: 528

Pathways

KEGG:

Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Steroid hormone biosynthesis
Retinol metabolism
Porphyrin metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Biosynthesis of cofactors
Bile secretion
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation

Reactome:

Glucuronidation

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	21499247

Unknown
Disease term	Disease name	Evidence	References	Source
Hypogonadism	Hypogonadism			GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Bantu siderosis	Associate	25233931
Carcinoma Hepatocellular	Associate	29438977
Cholangiocarcinoma	Associate	36199423
Hepatic Veno Occlusive Disease	Associate	31790828
Melanoma	Associate	23110092
Neoplasms	Stimulate	23110092
Smoke Inhalation Injury	Associate	29631575
Stomach Neoplasms	Associate	28586067