Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
7341
Gene name Gene Name - the full gene name approved by the HGNC.
Small ubiquitin like modifier 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SUMO1
Synonyms (NCBI Gene) Gene synonyms aliases
DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
OFC10
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q33.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unl
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT036934 hsa-miR-877-3p CLASH 23622248
MIRT679095 hsa-miR-431-3p HITS-CLIP 23824327
MIRT679094 hsa-miR-383-3p HITS-CLIP 23824327
MIRT679093 hsa-miR-9-5p HITS-CLIP 23824327
MIRT679092 hsa-miR-7977 HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
BCL6 Repression 22723377
GATA4 Unknown 15337742
STAT5A Repression 22723377
YBX1 Repression 20596676
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II TAS
GO:0003723 Function RNA binding HDA 22658674
GO:0005515 Function Protein binding IPI 11112409, 11735126, 11948183, 12072434, 14516784, 15296745, 15959518, 15983381, 16154161, 16189514, 16204249, 16494873, 16732283, 16763556, 17000644, 17036045, 17081985, 17099698, 17099700, 17491593, 17535915, 17942705, 17956732, 18264111, 18408014, 18617892, 18820298, 19684601, 197
GO:0005634 Component Nucleus HDA 16791210
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601912 12502 ENSG00000116030
Protein
UniProt ID P63165
Protein name Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)
Protein function Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2
PDB 1A5R , 1TGZ , 1WYW , 1Y8R , 1Z5S , 2ASQ , 2BF8 , 2G4D , 2IO2 , 2IY0 , 2IY1 , 2KQS , 2LAS , 2MW5 , 2N1A , 2N1V , 2PE6 , 2UYZ , 2VRR , 3KYC , 3KYD , 3RZW , 3UIP , 4WJN , 4WJO , 4WJP , 4WJQ , 5AEK , 5B7A , 5ELJ , 5GHD , 6EOP , 6EOT , 6J4I , 6JXU , 6JXV , 6K5T , 6TRW , 6UYO , 6UYP , 6UYQ , 6UYR , 6UYS , 6UYT , 6UYU , 6UYV , 6UYX , 6UYY , 6UYZ , 6V7P , 6V7Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11976 Rad60-SLD 22 92 Ubiquitin-2 like Rad60 SUMO-like Family
Sequence
Sequence length 101
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Nucleocytoplasmic transport
Fluid shear stress and atherosclerosis
  SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMO E3 ligases SUMOylate target proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
Regulation of IFNG signaling
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cleft lip with or without cleft palate Cleft Lip with or without Cleft Palate rs1591672193, rs1849496525, rs768861538, rs201543002, rs2061409627, rs2062048292, rs1314067686, rs780642639, rs2062949363, rs779785581, rs142168544, rs751873605, rs759207947, rs1367108095, rs1961434061
View all (1 more)
22492558
Oligodontia Oligodontia rs1591901585
Orofacial cleft OROFACIAL CLEFT 5, OROFACIAL CLEFT 10 rs28933081, rs387906597, rs1560277554 16990542, 22492558
Unknown
Disease term Disease name Evidence References Source
Orofacial Cleft orofacial cleft 10 GenCC
Myocardial Infarction Myocardial Infarction GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 30393970, 31489957
Alveolar Bone Loss Stimulate 34663464
Alzheimer Disease Associate 18675254, 27084229
Amyopathic dermatomyositis Associate 32033996
Amyotrophic Lateral Sclerosis Associate 24971881
Arthritis Rheumatoid Associate 17360386, 19565496
Brain Neoplasms Associate 23078246
Breast Neoplasms Associate 17079232
Carcinoma Embryonal Associate 10187798
Carcinoma Hepatocellular Associate 37730133