Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	7329
Gene name	Ubiquitin conjugating enzyme E2 I
Gene symbol	UBE2I
Synonyms (NCBI Gene)	C358B7.1P18UBC9
Chromosome	16
Chromosome location	16p13.3
Summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju

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miRTarBase ID	miRNA	Experiments	Reference
MIRT003339	hsa-miR-30e-5p	Review	20026422
MIRT003339	hsa-miR-30e-5p	Luciferase reporter assayqRT-PCRWestern blot	19223510
MIRT003339	hsa-miR-30e-5p	Luciferase reporter assayqRT-PCRWestern blot	19223510
MIRT005090	hsa-miR-30c-5p	Luciferase reporter assayqRT-PCRWestern blot	19223510
MIRT005090	hsa-miR-30c-5p	Luciferase reporter assayqRT-PCRWestern blot	19223510
MIRT005088	hsa-miR-188-5p	qRT-PCRWestern blot	19223510
MIRT005087	hsa-miR-200c-3p	qRT-PCRWestern blot	19223510
MIRT023885	hsa-miR-1-3p	Proteomics	18668040
MIRT032401	hsa-let-7b-5p	Proteomics	18668040
MIRT043111	hsa-miR-324-5p	CLASH	23622248
MIRT053795	hsa-miR-214-3p	Luciferase reporter assayqRT-PCRWestern blot	23187003
MIRT737310	hsa-miR-195-3p	MicroarrayqRT-PCR	27144577
MIRT1467905	hsa-miR-200b	CLIP-seq
MIRT1467906	hsa-miR-200c	CLIP-seq
MIRT1467907	hsa-miR-203	CLIP-seq
MIRT1467908	hsa-miR-30a	CLIP-seq
MIRT1467909	hsa-miR-30b	CLIP-seq
MIRT1467910	hsa-miR-30c	CLIP-seq
MIRT1467911	hsa-miR-30d	CLIP-seq
MIRT1467912	hsa-miR-30e	CLIP-seq
MIRT1467913	hsa-miR-3120-3p	CLIP-seq
MIRT1467914	hsa-miR-3613-5p	CLIP-seq
MIRT1467915	hsa-miR-374a	CLIP-seq
MIRT1467916	hsa-miR-374b	CLIP-seq
MIRT1467917	hsa-miR-3913-3p	CLIP-seq
MIRT1467918	hsa-miR-3960	CLIP-seq
MIRT1467919	hsa-miR-409-3p	CLIP-seq
MIRT1467920	hsa-miR-429	CLIP-seq
MIRT1467921	hsa-miR-4480	CLIP-seq
MIRT1467922	hsa-miR-4649-3p	CLIP-seq
MIRT1467923	hsa-miR-4699-3p	CLIP-seq
MIRT1467924	hsa-miR-4775	CLIP-seq
MIRT1467925	hsa-miR-4795-5p	CLIP-seq
MIRT1467926	hsa-miR-489	CLIP-seq
MIRT1467927	hsa-miR-519a	CLIP-seq
MIRT1467928	hsa-miR-519b-3p	CLIP-seq
MIRT1467929	hsa-miR-519c-3p	CLIP-seq
MIRT1467930	hsa-miR-587	CLIP-seq
MIRT1467931	hsa-miR-590-3p	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq
MIRT2140615	hsa-miR-125a-3p	CLIP-seq
MIRT2140616	hsa-miR-15a	CLIP-seq
MIRT2140617	hsa-miR-15b	CLIP-seq
MIRT2140618	hsa-miR-16	CLIP-seq
MIRT2140619	hsa-miR-195	CLIP-seq
MIRT2140620	hsa-miR-2467-5p	CLIP-seq
MIRT2140621	hsa-miR-297	CLIP-seq
MIRT2140622	hsa-miR-3064-3p	CLIP-seq
MIRT2140623	hsa-miR-3149	CLIP-seq
MIRT2140624	hsa-miR-3154	CLIP-seq
MIRT2140625	hsa-miR-3188	CLIP-seq
MIRT2140626	hsa-miR-3661	CLIP-seq
MIRT2140627	hsa-miR-3667-3p	CLIP-seq
MIRT2140628	hsa-miR-371b-5p	CLIP-seq
MIRT1467918	hsa-miR-3960	CLIP-seq
MIRT2140629	hsa-miR-3975	CLIP-seq
MIRT2140630	hsa-miR-424	CLIP-seq
MIRT2140631	hsa-miR-4289	CLIP-seq
MIRT2140632	hsa-miR-4457	CLIP-seq
MIRT1467922	hsa-miR-4649-3p	CLIP-seq
MIRT2140633	hsa-miR-4690-3p	CLIP-seq
MIRT2140634	hsa-miR-4726-3p	CLIP-seq
MIRT2140635	hsa-miR-4777-5p	CLIP-seq
MIRT2140636	hsa-miR-485-5p	CLIP-seq
MIRT2140637	hsa-miR-497	CLIP-seq
MIRT2140638	hsa-miR-518d-5p	CLIP-seq
MIRT2140639	hsa-miR-519b-5p	CLIP-seq
MIRT2140640	hsa-miR-519c-5p	CLIP-seq
MIRT2140641	hsa-miR-520c-5p	CLIP-seq
MIRT2140642	hsa-miR-526a	CLIP-seq
MIRT2140643	hsa-miR-615-5p	CLIP-seq
MIRT2140644	hsa-miR-616	CLIP-seq
MIRT2140645	hsa-miR-624	CLIP-seq
MIRT2140646	hsa-miR-631	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq
MIRT2361521	hsa-miR-10a	CLIP-seq
MIRT2361522	hsa-miR-10b	CLIP-seq
MIRT2361523	hsa-miR-1253	CLIP-seq
MIRT2140615	hsa-miR-125a-3p	CLIP-seq
MIRT2361524	hsa-miR-1275	CLIP-seq
MIRT2361525	hsa-miR-1301	CLIP-seq
MIRT1467905	hsa-miR-200b	CLIP-seq
MIRT1467906	hsa-miR-200c	CLIP-seq
MIRT1467907	hsa-miR-203	CLIP-seq
MIRT1467913	hsa-miR-3120-3p	CLIP-seq
MIRT2361526	hsa-miR-3130-3p	CLIP-seq
MIRT2361527	hsa-miR-3163	CLIP-seq
MIRT2361528	hsa-miR-3177-3p	CLIP-seq
MIRT2361529	hsa-miR-3194-3p	CLIP-seq
MIRT2361530	hsa-miR-331-3p	CLIP-seq
MIRT2361531	hsa-miR-3688-3p	CLIP-seq
MIRT1467915	hsa-miR-374a	CLIP-seq
MIRT1467916	hsa-miR-374b	CLIP-seq
MIRT1467917	hsa-miR-3913-3p	CLIP-seq
MIRT2361532	hsa-miR-3928	CLIP-seq
MIRT2361533	hsa-miR-3944-5p	CLIP-seq
MIRT1467918	hsa-miR-3960	CLIP-seq
MIRT2361534	hsa-miR-4261	CLIP-seq
MIRT2140631	hsa-miR-4289	CLIP-seq
MIRT1467920	hsa-miR-429	CLIP-seq
MIRT2361535	hsa-miR-4292	CLIP-seq
MIRT1467921	hsa-miR-4480	CLIP-seq
MIRT2361536	hsa-miR-4525	CLIP-seq
MIRT1467922	hsa-miR-4649-3p	CLIP-seq
MIRT2361537	hsa-miR-4652-5p	CLIP-seq
MIRT2361538	hsa-miR-4660	CLIP-seq
MIRT2361539	hsa-miR-4665-5p	CLIP-seq
MIRT1467923	hsa-miR-4699-3p	CLIP-seq
MIRT2361540	hsa-miR-4723-5p	CLIP-seq
MIRT2361541	hsa-miR-4725-5p	CLIP-seq
MIRT2140634	hsa-miR-4726-3p	CLIP-seq
MIRT2361542	hsa-miR-4763-5p	CLIP-seq
MIRT1467924	hsa-miR-4775	CLIP-seq
MIRT2361543	hsa-miR-4793-3p	CLIP-seq
MIRT1467926	hsa-miR-489	CLIP-seq
MIRT2361544	hsa-miR-504	CLIP-seq
MIRT2361545	hsa-miR-5047	CLIP-seq
MIRT1467927	hsa-miR-519a	CLIP-seq
MIRT1467928	hsa-miR-519b-3p	CLIP-seq
MIRT1467929	hsa-miR-519c-3p	CLIP-seq
MIRT1467930	hsa-miR-587	CLIP-seq
MIRT1467931	hsa-miR-590-3p	CLIP-seq
MIRT2140644	hsa-miR-616	CLIP-seq
MIRT2361546	hsa-miR-625	CLIP-seq
MIRT2361547	hsa-miR-637	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq
MIRT2140615	hsa-miR-125a-3p	CLIP-seq
MIRT2140634	hsa-miR-4726-3p	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq
MIRT2361521	hsa-miR-10a	CLIP-seq
MIRT2361522	hsa-miR-10b	CLIP-seq
MIRT2655289	hsa-miR-1252	CLIP-seq
MIRT1467905	hsa-miR-200b	CLIP-seq
MIRT1467906	hsa-miR-200c	CLIP-seq
MIRT1467907	hsa-miR-203	CLIP-seq
MIRT1467913	hsa-miR-3120-3p	CLIP-seq
MIRT2361527	hsa-miR-3163	CLIP-seq
MIRT2655290	hsa-miR-3613-3p	CLIP-seq
MIRT2361531	hsa-miR-3688-3p	CLIP-seq
MIRT1467915	hsa-miR-374a	CLIP-seq
MIRT1467916	hsa-miR-374b	CLIP-seq
MIRT1467917	hsa-miR-3913-3p	CLIP-seq
MIRT1467918	hsa-miR-3960	CLIP-seq
MIRT2361534	hsa-miR-4261	CLIP-seq
MIRT1467920	hsa-miR-429	CLIP-seq
MIRT2361541	hsa-miR-4725-5p	CLIP-seq
MIRT1467924	hsa-miR-4775	CLIP-seq
MIRT1467926	hsa-miR-489	CLIP-seq
MIRT2361544	hsa-miR-504	CLIP-seq
MIRT2655291	hsa-miR-548n	CLIP-seq
MIRT2655292	hsa-miR-548t	CLIP-seq
MIRT2655293	hsa-miR-561	CLIP-seq
MIRT1467931	hsa-miR-590-3p	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq
MIRT2361521	hsa-miR-10a	CLIP-seq
MIRT2361522	hsa-miR-10b	CLIP-seq
MIRT2655289	hsa-miR-1252	CLIP-seq
MIRT1467905	hsa-miR-200b	CLIP-seq
MIRT1467906	hsa-miR-200c	CLIP-seq
MIRT1467907	hsa-miR-203	CLIP-seq
MIRT1467913	hsa-miR-3120-3p	CLIP-seq
MIRT2361527	hsa-miR-3163	CLIP-seq
MIRT2655290	hsa-miR-3613-3p	CLIP-seq
MIRT2361531	hsa-miR-3688-3p	CLIP-seq
MIRT1467915	hsa-miR-374a	CLIP-seq
MIRT1467916	hsa-miR-374b	CLIP-seq
MIRT1467917	hsa-miR-3913-3p	CLIP-seq
MIRT1467918	hsa-miR-3960	CLIP-seq
MIRT2361534	hsa-miR-4261	CLIP-seq
MIRT1467920	hsa-miR-429	CLIP-seq
MIRT2361541	hsa-miR-4725-5p	CLIP-seq
MIRT1467924	hsa-miR-4775	CLIP-seq
MIRT1467926	hsa-miR-489	CLIP-seq
MIRT2361544	hsa-miR-504	CLIP-seq
MIRT2655291	hsa-miR-548n	CLIP-seq
MIRT2655292	hsa-miR-548t	CLIP-seq
MIRT2655293	hsa-miR-561	CLIP-seq
MIRT1467931	hsa-miR-590-3p	CLIP-seq
MIRT1467932	hsa-miR-652	CLIP-seq
MIRT1467933	hsa-miR-7	CLIP-seq

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Transcription factor	Regulation	Reference
WT1	Repression	8798754

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	19955185
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	TAS
GO:0000166	Function	Nucleotide binding	IEA
GO:0000795	Component	Synaptonemal complex	TAS	8610150
GO:0001221	Function	Transcription coregulator binding	IPI	20215116
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	9885291, 10871618, 11112409, 11278694, 11313457, 11735126, 12072434, 14516784, 14752048, 15231748, 15983381, 16154161, 16166628, 16189514, 16494873, 16631117, 16713569, 16730941, 16732283, 16998888, 17036045, 17037517, 17491593, 17643372, 17956732, 18087039, 18264111, 18624398, 1945
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9223278, 14752048, 16631117, 27068747
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	TAS
GO:0005643	Component	Nuclear pore	NAS	27160050
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	9223278
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	TAS	8565643
GO:0007059	Process	Chromosome segregation	IEA
GO:0007084	Process	Mitotic nuclear membrane reassembly	TAS
GO:0008134	Function	Transcription factor binding	IPI	19744555
GO:0016604	Component	Nuclear body	IEA
GO:0016605	Component	PML body	IDA	9885291
GO:0016740	Function	Transferase activity	IEA
GO:0016925	Process	Protein sumoylation	IBA
GO:0016925	Process	Protein sumoylation	IDA	15660128, 19955185, 21968017, 22194619, 25187565
GO:0016925	Process	Protein sumoylation	IEA
GO:0016925	Process	Protein sumoylation	IMP	26620705
GO:0016925	Process	Protein sumoylation	TAS
GO:0019789	Function	SUMO transferase activity	EXP	11877416, 12641448, 16029420
GO:0019789	Function	SUMO transferase activity	IEA
GO:0019789	Function	SUMO transferase activity	TAS
GO:0019899	Function	Enzyme binding	IPI	17087506
GO:0030335	Process	Positive regulation of cell migration	IMP	20023705
GO:0036211	Process	Protein modification process	TAS	8798754
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043398	Function	HLH domain binding	IEA
GO:0044388	Function	Small protein activating enzyme binding	IPI	15660128
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	16631117
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0051168	Process	Nuclear export	EXP	27160050
GO:0051301	Process	Cell division	IEA
GO:0061656	Function	SUMO conjugating enzyme activity	IBA
GO:0061656	Function	SUMO conjugating enzyme activity	IDA	19955185, 25187565
GO:0061656	Function	SUMO conjugating enzyme activity	IEA
GO:0071535	Function	RING-like zinc finger domain binding	IPI	19407830
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099523	Component	Presynaptic cytosol	IEA
GO:0099524	Component	Postsynaptic cytosol	IEA
GO:0106068	Component	SUMO ligase complex	IEA
GO:0106068	Component	SUMO ligase complex	IPI	22194619
GO:1990234	Component	Transferase complex	IDA	19955185

MIM	HGNC	e!Ensembl
601661	12485	ENSG00000103275

P63279

Protein name

SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)

Protein function

Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catal

PDB

1A3S , 1KPS , 1Z5S , 2GRN , 2GRO , 2GRP , 2GRQ , 2GRR , 2O25 , 2PE6 , 2PX9 , 2XWU , 3A4S , 3UIN , 3UIO , 3UIP , 4W5V , 4Y1L , 5D2M , 5F6D , 5F6E , 5F6U , 5F6V , 5F6W , 5F6X , 5F6Y , 5FQ2 , 6SYF , 8ODR , 9B62

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00179	UQ_con	8 → 152	Ubiquitin-conjugating enzyme	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus. {ECO:0000269|PubMed:8610150}.

Sequence

MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKL
RMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELL
NEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS

Sequence length

158

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport NF-kappa B signaling pathway Ubiquitin mediated proteolysis MicroRNAs in cancer		Vitamin D (calciferol) metabolism SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
See cases	Uncertain significance	rs2548142480	RCV002467404

Show/Hide Text Mining Associations (48)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
ACTH Secreting Pituitary Adenoma	Associate	21467194
Adenocarcinoma	Associate	36193060
Adenocarcinoma of Lung	Stimulate	28572537
Alzheimer Disease	Associate	18675254
Breast Neoplasms	Stimulate	19223510
Breast Neoplasms	Associate	21880185, 23873416, 24086615, 30011797
Carcinogenesis	Associate	19965618, 21880185, 28253371
Carcinoma Ductal	Associate	21880185
Carcinoma Hepatocellular	Associate	28572537, 36193060, 36748193
Carcinoma Ovarian Epithelial	Associate	23708104
Cataract	Associate	32827359
Cholangiocarcinoma	Associate	36193060
Colonic Neoplasms	Associate	36193060
Colorectal Neoplasms	Associate	26416353, 36193060, 37950153
Diabetes Mellitus Type 2	Associate	22114711
Digestive System Neoplasms	Associate	36193060
Endometrial Neoplasms	Associate	35830453
Fibrosis	Associate	28358817
Frontotemporal Dementia	Inhibit	25580532
Glioma	Associate	23187003
Head and Neck Neoplasms	Associate	28253371
Hereditary Breast and Ovarian Cancer Syndrome	Associate	24086615
Hypoxia	Associate	30612578
Inflammation	Associate	33244139
Insulin Resistance	Associate	22114711
Leukemia Myeloid Acute	Associate	17671234
Leukoplakia	Associate	36444596
Liver Cirrhosis	Associate	28358817
Liver Failure	Associate	28358817
Lung Neoplasms	Associate	30612578
Lymphatic Metastasis	Associate	21880185
Melanoma	Associate	28572537
Multiple Myeloma	Associate	19965618
Neoplasm Metastasis	Associate	36193060
Neoplasms	Associate	12813045, 19223510, 21880185, 23187003, 26416353, 28253371, 32576812
Neoplasms	Stimulate	28572537
Neoplasms	Inhibit	32064753
Ovarian Neoplasms	Associate	28572537
Pancreatic Neoplasms	Associate	36193060
Polycystic Ovary Syndrome	Associate	35830453
Precancerous Conditions	Associate	28253371
Progeria	Associate	21670151
Prostatic Neoplasms	Associate	30631151
Rett Syndrome	Associate	10745042
Squamous Cell Carcinoma of Head and Neck	Associate	32064753, 36444596
Stomach Neoplasms	Associate	36193060
Urinary Bladder Neoplasms	Associate	33244139
Uterine Cervicitis	Associate	28253371

UBE2I (ubiquitin conjugating enzyme E2 I)