Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	7262
Gene name Gene Name - the full gene name approved by the HGNC.	Pleckstrin homology like domain family A member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PHLDA2
Synonyms (NCBI Gene) Gene synonyms aliases	BRW1C, BWR1C, HLDA2, IPL, TSSC3
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p15.4
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarco

Show/Hide all(100)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016330	hsa-miR-193b-3p	Microarray	20304954
MIRT028418	hsa-miR-30a-5p	Proteomics	18668040
MIRT029073	hsa-miR-26b-5p	Microarray	19088304
MIRT031541	hsa-miR-16-5p	Proteomics	18668040
MIRT700821	hsa-miR-6819-3p	HITS-CLIP	23313552
MIRT700820	hsa-miR-6877-3p	HITS-CLIP	23313552
MIRT700819	hsa-miR-4446-3p	HITS-CLIP	23313552
MIRT700818	hsa-miR-1205	HITS-CLIP	23313552
MIRT700817	hsa-miR-93-3p	HITS-CLIP	23313552
MIRT700816	hsa-miR-3692-5p	HITS-CLIP	23313552
MIRT700815	hsa-miR-339-3p	HITS-CLIP	23313552
MIRT700814	hsa-miR-6132	HITS-CLIP	23313552
MIRT700813	hsa-miR-6836-5p	HITS-CLIP	23313552
MIRT700812	hsa-miR-1909-3p	HITS-CLIP	23313552
MIRT700811	hsa-miR-6722-3p	HITS-CLIP	23313552
MIRT700810	hsa-miR-3195	HITS-CLIP	23313552
MIRT700809	hsa-miR-3135b	HITS-CLIP	23313552
MIRT700808	hsa-miR-185-5p	HITS-CLIP	23313552
MIRT700807	hsa-miR-4306	HITS-CLIP	23313552
MIRT700806	hsa-miR-4644	HITS-CLIP	23313552
MIRT700805	hsa-miR-5192	HITS-CLIP	23313552
MIRT700804	hsa-miR-3652	HITS-CLIP	23313552
MIRT700803	hsa-miR-4430	HITS-CLIP	23313552
MIRT700802	hsa-miR-4492	HITS-CLIP	23313552
MIRT700801	hsa-miR-4498	HITS-CLIP	23313552
MIRT700800	hsa-miR-5001-5p	HITS-CLIP	23313552
MIRT700799	hsa-miR-762	HITS-CLIP	23313552
MIRT700798	hsa-miR-6828-3p	HITS-CLIP	23313552
MIRT700797	hsa-miR-6071	HITS-CLIP	23313552
MIRT471109	hsa-miR-548e-5p	PAR-CLIP	23592263
MIRT471108	hsa-miR-193a-3p	PAR-CLIP	23592263
MIRT016330	hsa-miR-193b-3p	PAR-CLIP	23592263
MIRT471107	hsa-miR-8062	PAR-CLIP	23592263
MIRT471106	hsa-miR-3190-5p	PAR-CLIP	23592263
MIRT471105	hsa-miR-4480	PAR-CLIP	23592263
MIRT471104	hsa-miR-3926	PAR-CLIP	23592263
MIRT471103	hsa-miR-106a-3p	PAR-CLIP	23592263
MIRT471102	hsa-miR-548s	PAR-CLIP	23592263
MIRT471101	hsa-miR-450b-5p	PAR-CLIP	23592263
MIRT700821	hsa-miR-6819-3p	HITS-CLIP	23313552
MIRT700820	hsa-miR-6877-3p	HITS-CLIP	23313552
MIRT700819	hsa-miR-4446-3p	HITS-CLIP	23313552
MIRT700818	hsa-miR-1205	HITS-CLIP	23313552
MIRT700817	hsa-miR-93-3p	HITS-CLIP	23313552
MIRT700816	hsa-miR-3692-5p	HITS-CLIP	23313552
MIRT700815	hsa-miR-339-3p	HITS-CLIP	23313552
MIRT700814	hsa-miR-6132	HITS-CLIP	23313552
MIRT700813	hsa-miR-6836-5p	HITS-CLIP	23313552
MIRT700812	hsa-miR-1909-3p	HITS-CLIP	23313552
MIRT700811	hsa-miR-6722-3p	HITS-CLIP	23313552
MIRT700810	hsa-miR-3195	HITS-CLIP	23313552
MIRT700809	hsa-miR-3135b	HITS-CLIP	23313552
MIRT700808	hsa-miR-185-5p	HITS-CLIP	23313552
MIRT700807	hsa-miR-4306	HITS-CLIP	23313552
MIRT700806	hsa-miR-4644	HITS-CLIP	23313552
MIRT700805	hsa-miR-5192	HITS-CLIP	23313552
MIRT700804	hsa-miR-3652	HITS-CLIP	23313552
MIRT700803	hsa-miR-4430	HITS-CLIP	23313552
MIRT700802	hsa-miR-4492	HITS-CLIP	23313552
MIRT700801	hsa-miR-4498	HITS-CLIP	23313552
MIRT700800	hsa-miR-5001-5p	HITS-CLIP	23313552
MIRT700799	hsa-miR-762	HITS-CLIP	23313552
MIRT700798	hsa-miR-6828-3p	HITS-CLIP	23313552
MIRT700797	hsa-miR-6071	HITS-CLIP	23313552
MIRT471109	hsa-miR-548e-5p	PAR-CLIP	23592263
MIRT471108	hsa-miR-193a-3p	PAR-CLIP	23592263
MIRT016330	hsa-miR-193b-3p	PAR-CLIP	23592263
MIRT471107	hsa-miR-8062	PAR-CLIP	23592263
MIRT471106	hsa-miR-3190-5p	PAR-CLIP	23592263
MIRT471105	hsa-miR-4480	PAR-CLIP	23592263
MIRT471104	hsa-miR-3926	PAR-CLIP	23592263
MIRT471103	hsa-miR-106a-3p	PAR-CLIP	23592263
MIRT471102	hsa-miR-548s	PAR-CLIP	23592263
MIRT471101	hsa-miR-450b-5p	PAR-CLIP	23592263
MIRT1232016	hsa-miR-1283	CLIP-seq
MIRT1232017	hsa-miR-134	CLIP-seq
MIRT1232018	hsa-miR-1973	CLIP-seq
MIRT1232019	hsa-miR-3118	CLIP-seq
MIRT1232020	hsa-miR-3133	CLIP-seq
MIRT1232021	hsa-miR-3163	CLIP-seq
MIRT1232022	hsa-miR-3164	CLIP-seq
MIRT1232023	hsa-miR-323b-3p	CLIP-seq
MIRT1232024	hsa-miR-376c	CLIP-seq
MIRT1232025	hsa-miR-4501	CLIP-seq
MIRT1232026	hsa-miR-520d-5p	CLIP-seq
MIRT1232027	hsa-miR-524-3p	CLIP-seq
MIRT1232028	hsa-miR-524-5p	CLIP-seq
MIRT1232029	hsa-miR-525-3p	CLIP-seq
MIRT1232030	hsa-miR-548b-3p	CLIP-seq
MIRT2068062	hsa-miR-185	CLIP-seq
MIRT2068063	hsa-miR-1909	CLIP-seq
MIRT2068064	hsa-miR-3182	CLIP-seq
MIRT2068065	hsa-miR-4659a-3p	CLIP-seq
MIRT2068066	hsa-miR-4659b-3p	CLIP-seq
MIRT2068067	hsa-miR-4661-3p	CLIP-seq
MIRT2068068	hsa-miR-4681	CLIP-seq
MIRT2068069	hsa-miR-4746-5p	CLIP-seq
MIRT1232027	hsa-miR-524-3p	CLIP-seq
MIRT1232029	hsa-miR-525-3p	CLIP-seq
MIRT2068070	hsa-miR-937	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001890	Process	Placenta development	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0006915	Process	Apoptotic process	TAS	9328465
GO:0009887	Process	Animal organ morphogenesis	IEA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016020	Component	Membrane	IEA
GO:0030334	Process	Regulation of cell migration	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0045995	Process	Regulation of embryonic development	IEA
GO:0060721	Process	Regulation of spongiotrophoblast cell proliferation	IEA
GO:0070873	Process	Regulation of glycogen metabolic process	IEA
GO:1901981	Function	Phosphatidylinositol phosphate binding	IEA
GO:1903547	Process	Regulation of growth hormone activity	IEA

MIM	HGNC	e!Ensembl
602131	12385	ENSG00000181649

Protein

UniProt ID

Q53GA4

Protein name

Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable f

Protein function

Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity).

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal

Sequence

MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRARPKELRFHSILKVDC
VERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQNRRALQDFRSRQERTAPA
APAEDAVAAAAAAPSEPSEPSRPSPQPKPRTP

Sequence length

152

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Lung carcinoma	Non-Small Cell Lung Carcinoma	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355 View all (44 more)	15496427

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Gout	Gout			GWAS

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text Mining
Abortion Habitual	Associate	27929073
Abortion Spontaneous	Associate	20484977
Breast Neoplasms	Associate	39300389
Carcinogenesis	Inhibit	30092789
Carcinogenesis	Associate	32385195
Carcinoma Hepatocellular	Associate	37474643
Carcinoma Pancreatic Ductal	Associate	29660218
Colorectal Neoplasms	Stimulate	32385195
Diabetes Gestational	Stimulate	31194812
Diabetic Nephropathies	Associate	37986381
Fetal Death	Associate	20484977
Fetal Diseases	Associate	26944942
Fetal Growth Retardation	Stimulate	19483473, 24986528, 33389447
Fetal Growth Retardation	Associate	23243085, 26944942
Fibrosis	Inhibit	34284400
Genetic Diseases Inborn	Associate	9520460
Neoplasm Metastasis	Associate	26265454
Neoplasm Metastasis	Inhibit	30092789
Neoplasms	Associate	26265454, 29660218, 32385195, 34284400, 35831322, 39300389, 9403053, 9520460
Neoplasms	Inhibit	30092789
Nevus	Associate	15314611
Osteosarcoma	Associate	26265454, 30092789
Pneumonia Ventilator Associated	Associate	32031163

PHLDA2 (pleckstrin homology like domain family A member 2)