HSP90B1 (heat shock protein 90 beta family member 1)

Gene

• Entrez ID: 7184
• Gene name: Heat shock protein 90 beta family member 1
• Gene symbol: HSP90B1
• Synonyms (NCBI Gene): ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1
• Chromosome: 12
• Chromosome location: 12q23.3
• Summary: This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT003874	hsa-miR-15a-5p	Microarray	18362358
MIRT004368	hsa-miR-16-5p	Microarray	18362358
MIRT004158	hsa-miR-192-5p	Microarray	16822819
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay	23208072
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay	23208072
MIRT017651	hsa-miR-335-5p	Microarray	18185580
MIRT020159	hsa-miR-130b-3p	Sequencing	20371350
MIRT023707	hsa-miR-1-3p	Proteomics	18668040
MIRT025974	hsa-miR-148a-3p	Sequencing	20371350
MIRT049100	hsa-miR-92a-3p	CLASH	23622248
MIRT045853	hsa-miR-128-3p	CLASH	23622248
MIRT041729	hsa-miR-484	CLASH	23622248
MIRT041729	hsa-miR-484	CLASH	23622248
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT475512	hsa-miR-302f	PAR-CLIP	20371350
MIRT475509	hsa-miR-3123	PAR-CLIP	20371350
MIRT475507	hsa-miR-1910-3p	PAR-CLIP	20371350
MIRT475506	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT475502	hsa-miR-3919	PAR-CLIP	20371350
MIRT475498	hsa-miR-6125	PAR-CLIP	20371350
MIRT475495	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT475491	hsa-miR-658	PAR-CLIP	20371350
MIRT475489	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT475488	hsa-miR-1273e	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	23446348
MIRT523132	hsa-miR-206	PAR-CLIP	23446348
MIRT523131	hsa-miR-613	PAR-CLIP	23446348
MIRT523130	hsa-miR-433-3p	PAR-CLIP	23446348
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	23446348
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	23446348
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	23446348
MIRT523126	hsa-miR-4262	PAR-CLIP	23446348
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	23446348
MIRT523124	hsa-miR-4272	PAR-CLIP	23446348
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	23446348
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	23446348
MIRT523121	hsa-miR-3915	PAR-CLIP	23446348
MIRT475512	hsa-miR-302f	PAR-CLIP	23592263
MIRT475511	hsa-miR-512-5p	PAR-CLIP	23592263
MIRT475510	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT475509	hsa-miR-3123	PAR-CLIP	23592263
MIRT475508	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT475507	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT475506	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT475505	hsa-miR-3929	PAR-CLIP	23592263
MIRT475504	hsa-miR-4419b	PAR-CLIP	23592263
MIRT475503	hsa-miR-4478	PAR-CLIP	23592263
MIRT475502	hsa-miR-3919	PAR-CLIP	23592263
MIRT475501	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT475499	hsa-miR-4459	PAR-CLIP	23592263
MIRT475500	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT475498	hsa-miR-6125	PAR-CLIP	23592263
MIRT475497	hsa-miR-3664-3p	PAR-CLIP	23592263
MIRT475496	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT475495	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT475494	hsa-miR-1827	PAR-CLIP	23592263
MIRT475493	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT475492	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT475491	hsa-miR-658	PAR-CLIP	23592263
MIRT475490	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT475489	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT475488	hsa-miR-1273e	PAR-CLIP	23592263
MIRT475487	hsa-miR-665	PAR-CLIP	23592263
MIRT440482	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440482	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay, Western blot	25880332
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay, Western blot	25880332
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay, Western blot	25880332
MIRT007086	hsa-miR-223-3p	Luciferase reporter assay, Western blot	25880332
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT025974	hsa-miR-148a-3p	PAR-CLIP	26701625
MIRT475488	hsa-miR-1273e	PAR-CLIP	27292025
MIRT475495	hsa-miR-219b-3p	PAR-CLIP	27292025
MIRT475489	hsa-miR-25-5p	PAR-CLIP	27292025
MIRT475512	hsa-miR-302f	PAR-CLIP	27292025
MIRT475498	hsa-miR-6125	PAR-CLIP	27292025
MIRT475491	hsa-miR-658	PAR-CLIP	27292025
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	20371350
MIRT523132	hsa-miR-206	PAR-CLIP	20371350
MIRT523131	hsa-miR-613	PAR-CLIP	20371350
MIRT523130	hsa-miR-433-3p	PAR-CLIP	20371350
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	20371350
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	20371350
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	20371350
MIRT523126	hsa-miR-4262	PAR-CLIP	20371350
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	20371350
MIRT523124	hsa-miR-4272	PAR-CLIP	20371350
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	20371350
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	20371350
MIRT523121	hsa-miR-3915	PAR-CLIP	20371350
MIRT475512	hsa-miR-302f	PAR-CLIP	20371350
MIRT475509	hsa-miR-3123	PAR-CLIP	20371350
MIRT475507	hsa-miR-1910-3p	PAR-CLIP	20371350
MIRT475506	hsa-miR-6511a-5p	PAR-CLIP	20371350
MIRT475502	hsa-miR-3919	PAR-CLIP	20371350
MIRT475498	hsa-miR-6125	PAR-CLIP	20371350
MIRT475495	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT475491	hsa-miR-658	PAR-CLIP	20371350
MIRT475489	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT475488	hsa-miR-1273e	PAR-CLIP	20371350
MIRT023707	hsa-miR-1-3p	PAR-CLIP	23446348
MIRT523132	hsa-miR-206	PAR-CLIP	23446348
MIRT523131	hsa-miR-613	PAR-CLIP	23446348
MIRT523130	hsa-miR-433-3p	PAR-CLIP	23446348
MIRT523129	hsa-miR-181c-5p	PAR-CLIP	23446348
MIRT523128	hsa-miR-181a-5p	PAR-CLIP	23446348
MIRT523127	hsa-miR-181d-5p	PAR-CLIP	23446348
MIRT523126	hsa-miR-4262	PAR-CLIP	23446348
MIRT523125	hsa-miR-181b-5p	PAR-CLIP	23446348
MIRT523124	hsa-miR-4272	PAR-CLIP	23446348
MIRT523123	hsa-miR-3928-3p	PAR-CLIP	23446348
MIRT523122	hsa-miR-7154-5p	PAR-CLIP	23446348
MIRT523121	hsa-miR-3915	PAR-CLIP	23446348
MIRT475512	hsa-miR-302f	PAR-CLIP	23592263
MIRT475511	hsa-miR-512-5p	PAR-CLIP	23592263
MIRT475510	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT475509	hsa-miR-3123	PAR-CLIP	23592263
MIRT475508	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT475507	hsa-miR-1910-3p	PAR-CLIP	23592263
MIRT475506	hsa-miR-6511a-5p	PAR-CLIP	23592263
MIRT475505	hsa-miR-3929	PAR-CLIP	23592263
MIRT475504	hsa-miR-4419b	PAR-CLIP	23592263
MIRT475503	hsa-miR-4478	PAR-CLIP	23592263
MIRT475502	hsa-miR-3919	PAR-CLIP	23592263
MIRT475501	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT475499	hsa-miR-4459	PAR-CLIP	23592263
MIRT475500	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT475498	hsa-miR-6125	PAR-CLIP	23592263
MIRT475497	hsa-miR-3664-3p	PAR-CLIP	23592263
MIRT475496	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT475495	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT475494	hsa-miR-1827	PAR-CLIP	23592263
MIRT475493	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT475492	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT475491	hsa-miR-658	PAR-CLIP	23592263
MIRT475490	hsa-miR-7160-5p	PAR-CLIP	23592263
MIRT475489	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT475488	hsa-miR-1273e	PAR-CLIP	23592263
MIRT475487	hsa-miR-665	PAR-CLIP	23592263
MIRT1055890	hsa-miR-148a	CLIP-seq
MIRT1055891	hsa-miR-148b	CLIP-seq
MIRT1055892	hsa-miR-150	CLIP-seq
MIRT1055893	hsa-miR-152	CLIP-seq
MIRT1055894	hsa-miR-188-3p	CLIP-seq
MIRT1055895	hsa-miR-1909	CLIP-seq
MIRT1055896	hsa-miR-1914	CLIP-seq
MIRT1055897	hsa-miR-23a	CLIP-seq
MIRT1055898	hsa-miR-23b	CLIP-seq
MIRT1055899	hsa-miR-23c	CLIP-seq
MIRT1055900	hsa-miR-3122	CLIP-seq
MIRT1055901	hsa-miR-3171	CLIP-seq
MIRT1055902	hsa-miR-3913-5p	CLIP-seq
MIRT1055903	hsa-miR-3938	CLIP-seq
MIRT1055904	hsa-miR-4495	CLIP-seq
MIRT1055905	hsa-miR-450b-3p	CLIP-seq
MIRT1055906	hsa-miR-4643	CLIP-seq
MIRT1055907	hsa-miR-466	CLIP-seq
MIRT1055908	hsa-miR-4661-3p	CLIP-seq
MIRT1055909	hsa-miR-4693-3p	CLIP-seq
MIRT1055910	hsa-miR-4710	CLIP-seq
MIRT1055911	hsa-miR-4713-3p	CLIP-seq
MIRT1055912	hsa-miR-4713-5p	CLIP-seq
MIRT1055913	hsa-miR-4789-3p	CLIP-seq
MIRT1055914	hsa-miR-4789-5p	CLIP-seq
MIRT1055915	hsa-miR-4792	CLIP-seq
MIRT1055916	hsa-miR-513a-3p	CLIP-seq
MIRT1055917	hsa-miR-522	CLIP-seq
MIRT1055918	hsa-miR-532-3p	CLIP-seq
MIRT1055919	hsa-miR-638	CLIP-seq
MIRT1055920	hsa-miR-642a	CLIP-seq
MIRT1055921	hsa-miR-769-3p	CLIP-seq
MIRT1055890	hsa-miR-148a	CLIP-seq
MIRT1055891	hsa-miR-148b	CLIP-seq
MIRT1055893	hsa-miR-152	CLIP-seq
MIRT1055895	hsa-miR-1909	CLIP-seq
MIRT1055894	hsa-miR-188-3p	CLIP-seq
MIRT2245156	hsa-miR-181a	CLIP-seq
MIRT2245157	hsa-miR-181b	CLIP-seq
MIRT2245158	hsa-miR-181c	CLIP-seq
MIRT2245159	hsa-miR-181d	CLIP-seq
MIRT1055894	hsa-miR-188-3p	CLIP-seq
MIRT1055896	hsa-miR-1914	CLIP-seq
MIRT2245160	hsa-miR-223	CLIP-seq
MIRT1055897	hsa-miR-23a	CLIP-seq
MIRT1055898	hsa-miR-23b	CLIP-seq
MIRT1055899	hsa-miR-23c	CLIP-seq
MIRT2245161	hsa-miR-3074-5p	CLIP-seq
MIRT2245162	hsa-miR-3121-3p	CLIP-seq
MIRT1055903	hsa-miR-3938	CLIP-seq
MIRT2245163	hsa-miR-433	CLIP-seq
MIRT1055904	hsa-miR-4495	CLIP-seq
MIRT1055908	hsa-miR-4661-3p	CLIP-seq
MIRT2245164	hsa-miR-499-3p	CLIP-seq
MIRT2245165	hsa-miR-499a-3p	CLIP-seq
MIRT1055916	hsa-miR-513a-3p	CLIP-seq
MIRT1055920	hsa-miR-642a	CLIP-seq
MIRT2245166	hsa-miR-935	CLIP-seq
MIRT2245160	hsa-miR-223	CLIP-seq
MIRT2245164	hsa-miR-499-3p	CLIP-seq
MIRT2245165	hsa-miR-499a-3p	CLIP-seq
MIRT2245166	hsa-miR-935	CLIP-seq
MIRT2548076	hsa-miR-1	CLIP-seq
MIRT1055890	hsa-miR-148a	CLIP-seq
MIRT1055891	hsa-miR-148b	CLIP-seq
MIRT1055892	hsa-miR-150	CLIP-seq
MIRT1055893	hsa-miR-152	CLIP-seq
MIRT2245156	hsa-miR-181a	CLIP-seq
MIRT2245157	hsa-miR-181b	CLIP-seq
MIRT2245158	hsa-miR-181c	CLIP-seq
MIRT2245159	hsa-miR-181d	CLIP-seq
MIRT1055894	hsa-miR-188-3p	CLIP-seq
MIRT1055895	hsa-miR-1909	CLIP-seq
MIRT2245160	hsa-miR-223	CLIP-seq
MIRT1055897	hsa-miR-23a	CLIP-seq
MIRT1055898	hsa-miR-23b	CLIP-seq
MIRT1055899	hsa-miR-23c	CLIP-seq
MIRT2245162	hsa-miR-3121-3p	CLIP-seq
MIRT1055901	hsa-miR-3171	CLIP-seq
MIRT2548077	hsa-miR-3928	CLIP-seq
MIRT2245163	hsa-miR-433	CLIP-seq
MIRT1055904	hsa-miR-4495	CLIP-seq
MIRT1055912	hsa-miR-4713-5p	CLIP-seq
MIRT2245164	hsa-miR-499-3p	CLIP-seq
MIRT2245165	hsa-miR-499a-3p	CLIP-seq
MIRT1055916	hsa-miR-513a-3p	CLIP-seq
MIRT1055918	hsa-miR-532-3p	CLIP-seq
MIRT2548078	hsa-miR-548ac	CLIP-seq
MIRT2548079	hsa-miR-548d-3p	CLIP-seq
MIRT2548080	hsa-miR-548z	CLIP-seq
MIRT2245166	hsa-miR-935	CLIP-seq
MIRT2548076	hsa-miR-1	CLIP-seq
MIRT1055890	hsa-miR-148a	CLIP-seq
MIRT1055891	hsa-miR-148b	CLIP-seq
MIRT1055892	hsa-miR-150	CLIP-seq
MIRT1055893	hsa-miR-152	CLIP-seq
MIRT2245156	hsa-miR-181a	CLIP-seq
MIRT2245157	hsa-miR-181b	CLIP-seq
MIRT2245158	hsa-miR-181c	CLIP-seq
MIRT2245159	hsa-miR-181d	CLIP-seq
MIRT1055894	hsa-miR-188-3p	CLIP-seq
MIRT1055895	hsa-miR-1909	CLIP-seq
MIRT1055896	hsa-miR-1914	CLIP-seq
MIRT2245160	hsa-miR-223	CLIP-seq
MIRT1055897	hsa-miR-23a	CLIP-seq
MIRT1055898	hsa-miR-23b	CLIP-seq
MIRT1055899	hsa-miR-23c	CLIP-seq
MIRT2245161	hsa-miR-3074-5p	CLIP-seq
MIRT2245162	hsa-miR-3121-3p	CLIP-seq
MIRT1055901	hsa-miR-3171	CLIP-seq
MIRT2548077	hsa-miR-3928	CLIP-seq
MIRT2245163	hsa-miR-433	CLIP-seq
MIRT1055904	hsa-miR-4495	CLIP-seq
MIRT1055912	hsa-miR-4713-5p	CLIP-seq
MIRT2245164	hsa-miR-499-3p	CLIP-seq
MIRT2245165	hsa-miR-499a-3p	CLIP-seq
MIRT1055916	hsa-miR-513a-3p	CLIP-seq
MIRT1055918	hsa-miR-532-3p	CLIP-seq
MIRT2548078	hsa-miR-548ac	CLIP-seq
MIRT2548079	hsa-miR-548d-3p	CLIP-seq
MIRT2548080	hsa-miR-548z	CLIP-seq
MIRT2245166	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001666	Process	Response to hypoxia	IDA	15620698
GO:0003723	Function	RNA binding	IDA	11958450
GO:0004864	Function	Protein phosphatase inhibitor activity	IDA	19000834
GO:0005509	Function	Calcium ion binding	TAS	10497210
GO:0005515	Function	Protein binding	IPI	9596688, 11907036, 11958450, 15845869, 18264092, 23349634, 23995768, 26496610, 30021884, 32812023, 32814053, 35063084
GO:0005524	Function	ATP binding	IBA
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	17344063, 30188326
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	16130169
GO:0005788	Component	Endoplasmic reticulum lumen	IDA	10497210
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	10497210
GO:0005790	Component	Smooth endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA	9596688
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IDA	23572575
GO:0006457	Process	Protein folding	IEA
GO:0015031	Process	Protein transport	NAS	15845869
GO:0016020	Component	Membrane	HDA	19946888
GO:0016529	Component	Sarcoplasmic reticulum	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0019903	Function	Protein phosphatase binding	IDA	19000834
GO:0030177	Process	Positive regulation of Wnt signaling pathway	IDA	23572575, 39509507
GO:0030496	Component	Midbody	IDA	15166316
GO:0030970	Process	Retrograde protein transport, ER to cytosol	IMP	25660456
GO:0031247	Process	Actin rod assembly	IDA	19000834
GO:0032991	Component	Protein-containing complex	IDA	23349634
GO:0033018	Component	Sarcoplasmic reticulum lumen	IEA
GO:0034123	Process	Positive regulation of toll-like receptor signaling pathway	IDA	11584270
GO:0034663	Component	Endoplasmic reticulum chaperone complex	IEA
GO:0034975	Process	Protein folding in endoplasmic reticulum	TAS	22013210
GO:0034976	Process	Response to endoplasmic reticulum stress	TAS	22934019
GO:0036503	Process	ERAD pathway	IBA
GO:0036503	Process	ERAD pathway	IDA	24899641
GO:0036503	Process	ERAD pathway	IMP	18264092
GO:0042470	Component	Melanosome	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	10497210, 15192333
GO:0043066	Process	Negative regulation of apoptotic process	TAS	16130169
GO:0044183	Function	Protein folding chaperone	IDA	11584270, 39509507
GO:0048471	Component	Perinuclear region of cytoplasm	IBA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	10497210
GO:0050750	Function	Low-density lipoprotein particle receptor binding	IDA
GO:0051082	Function	Unfolded protein binding	IBA
GO:0051082	Function	Unfolded protein binding	IEA
GO:0051208	Process	Sequestering of calcium ion	NAS	15192333
GO:0070062	Component	Extracellular exosome	HDA	19199708, 20458337
GO:0071287	Process	Cellular response to manganese ion	IEA
GO:0071318	Process	Cellular response to ATP	IDA	19000834
GO:0071682	Component	Endocytic vesicle lumen	TAS
GO:0072659	Process	Protein localization to plasma membrane	IDA	23572575
GO:0097524	Component	Sperm plasma membrane	IEA
GO:0140662	Function	ATP-dependent protein folding chaperone	IDA	23572575
GO:0140662	Function	ATP-dependent protein folding chaperone	IEA

Other IDs

• MIM: 191175
• HGNC: 12028
• e!Ensembl: ENSG00000166598

Protein

• UniProt ID: P14625
• Protein name: Endoplasmin (EC 3.6.4.-) (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
• Protein function: ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LR
• PDB: 4NH9, 7ULL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02518	HATPase_c	96 → 255	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	Domain
  PF00183	HSP90	257 → 781	Hsp90 protein	Family

• Sequence:

  MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDG
  LNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISL
  TDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
  AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNT
  LGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAK
  EEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
  SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD
  DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKY
  NDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
  MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDE
  SEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMER
  IMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFET
  ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDE
  EMDVGTDEEEETAKESTAEKDEL

• Sequence length: 803

Pathways

KEGG:

Protein processing in endoplasmic reticulum
PI3K-Akt signaling pathway
IL-17 signaling pathway
Estrogen signaling pathway
Thyroid hormone synthesis
Salmonella infection
Pathways in cancer
Chemical carcinogenesis - receptor activation
Prostate cancer
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis

Reactome:

Trafficking and processing of endosomal TLR
Scavenging by Class A Receptors
ATF6 (ATF6-alpha) activates chaperone genes
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Interleukin-4 and Interleukin-13 signaling
Post-translational protein phosphorylation

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Benign	rs11547724	RCV005904559
Clear cell carcinoma of kidney	Benign	rs11547724	RCV005904560
Colon adenocarcinoma	Benign	rs11547724	RCV005904558
Gastric cancer	Benign	rs11547724	RCV005904562
Lung cancer	Benign	rs11547724	RCV005904566
Melanoma	Benign	rs11547724	RCV005904565
Ovarian serous cystadenocarcinoma	Uncertain significance; Benign	rs567564451, rs11547724	RCV005937517 RCV005904563
Sarcoma	Benign	rs11547724	RCV005904561
Thymoma	Benign	rs11547724	RCV005904564

Associations from Text Mining
Disease Name	Relationship Type	References
Acquired ichthyosis	Associate	36303457
Adenocarcinoma	Stimulate	31970893
Adenocarcinoma Of Esophagus	Associate	18331622
Adenocarcinoma of Lung	Associate	31970893, 36291587
Adenoma	Associate	26066753
Adrenocortical Carcinoma	Associate	36291587
Autoimmune Diseases	Associate	24816397, 33542414
Axial osteomalacia	Associate	34698138
Bipolar Disorder	Associate	18771604
Breast Neoplasms	Associate	22363530, 33145341
Burkitt Lymphoma	Associate	20723265, 37569852
Carcinogenesis	Associate	11335099, 17726464, 22363530, 26464709
Carcinoma Hepatocellular	Associate	11335099, 15069714, 15810071, 15965645, 23973991, 25225353, 25798051, 26718209, 37204028
Carcinoma Non Small Cell Lung	Associate	27599983
Carcinoma Renal Cell	Associate	36291587
Carcinoma Squamous Cell	Stimulate	20090101
Cholesteatoma	Associate	23852020
Cholesteatoma Middle Ear	Associate	23852020
Colitis Ulcerative	Stimulate	24146856
Colitis Ulcerative	Associate	35185383
Colonic Neoplasms	Associate	15742415, 17164780, 17464101
Colorectal Neoplasms	Associate	15742415, 28347227, 31796117, 34208855, 34476575, 35658213, 36303457
Colorectal Neoplasms	Stimulate	22152070
COVID 19	Associate	35677655
Crohn Disease	Associate	20587550, 29556615
Crohn Disease	Inhibit	24146856
Crohn Disease	Stimulate	31557250
Diabetes Mellitus	Associate	26167512, 33542414
Diabetes Mellitus Type 1	Associate	18429934, 26167512, 33542414, 36303457
Distal myopathy Nonaka type	Associate	23472144
Epilepsy Partial with Variable Foci	Associate	21075170
Esophageal Neoplasms	Associate	15637761
Esophageal Squamous Cell Carcinoma	Associate	20300187
Fanconi Anemia	Associate	15082718
Fibrosis	Associate	15069714
Gallbladder Neoplasms	Associate	25973087
Gastrointestinal Neoplasms	Associate	20300187
Glaucoma	Associate	23035116, 25027323, 29402077
Glioblastoma	Associate	26108672
Glioblastoma	Stimulate	26108996
Glioma	Associate	26108996
Glioma	Stimulate	40234584
Graft vs Host Disease	Associate	35486633
Graves Ophthalmopathy	Associate	33613444
Hypoxia	Stimulate	15620698
Hypoxia Brain	Stimulate	15620698
Idiopathic Noncirrhotic Portal Hypertension	Associate	36312597
Infections	Associate	20351288
Infertility	Associate	36303457
Inflammation	Associate	24146856, 36312597
Inflammatory Bowel Diseases	Associate	24146856
Leukemia Lymphocytic Chronic B Cell	Associate	25880332
Lewy Body Disease	Associate	22803570
Lung Neoplasms	Associate	21489244, 23374247, 31970893
Lymphatic Metastasis	Associate	27599983
Lymphoma B Cell	Associate	12200383
Macular Degeneration	Associate	30946360
Mast Cell Activation Disorders	Associate	35610596
Melanoma	Associate	36303457
Mouth Neoplasms	Associate	21992474
Multiple Myeloma	Associate	12200383, 20977755
Multiple Sclerosis	Stimulate	32640422
Myoclonic Epilepsy Juvenile	Associate	26945068
Myositis Inclusion Body	Associate	14695312
Nasopharyngeal Carcinoma	Associate	28216622
Nasopharyngeal Neoplasms	Associate	21992474
Neoplasm Invasiveness	Associate	24887297
Neoplasm Metastasis	Stimulate	15742415, 17464101, 20300187, 22363530
Neoplasm Metastasis	Associate	15810071, 21708117, 26718209, 34208855
Neoplasms	Associate	15069714, 15498555, 16274472, 17278882, 17464101, 17726464, 18331622, 20300187, 21992474, 22152070, 22363530, 22911792, 23839491, 25225353, 25798051, 26108672, 26363641, 26464709, 26718209, 26891914, 27599983, 31970893, 36291587, 36303457, 37156452, 37204028, 38035111, 38243263, 39278093
Neoplasms	Stimulate	15742415
Obesity	Stimulate	24986468
Oropharyngeal Neoplasms	Associate	30414263
Osteoporosis	Associate	34142171
Osteosarcoma	Associate	30816440
Polycystic Ovary Syndrome	Associate	27046189
Porphyria Cutanea Tarda	Associate	34476575
Post Acute COVID 19 Syndrome	Associate	36890149
Pre Eclampsia	Associate	24931423
Prostatic Neoplasms	Associate	36452480
Psychological Distress	Associate	39278093
Pulmonary Disease Chronic Obstructive	Associate	34449539
Pulmonary Fibrosis	Associate	37833927
Respiratory Distress Syndrome	Stimulate	22321564
Silicosis	Associate	37833927
Small Cell Lung Carcinoma	Associate	26464709
Squamous Cell Carcinoma of Head and Neck	Associate	17726464, 20497865, 26318431, 35610596
Stomach Neoplasms	Associate	15962384, 17464101, 28706421, 37156452
Tertiary Lymphoid Structures	Associate	18331622, 20300187
Thrombosis	Associate	40004202
Urinary Bladder Neoplasms	Associate	36291587, 37433010
Uterine Cervical Neoplasms	Associate	20090101, 23929391, 37400149
Vitiligo	Associate	36890149