Gene Gene information from NCBI Gene database.
Entrez ID 7182
Gene name Nuclear receptor subfamily 2 group C member 2
Gene symbol NR2C2
Synonyms (NCBI Gene)
TAK1TR4
Chromosome 3
Chromosome location 3p25.1
Summary This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis.
miRNA miRNA information provided by mirtarbase database.
1675
miRTarBase ID miRNA Experiments Reference
MIRT030801 hsa-miR-21-5p Microarray 18591254
MIRT039640 hsa-miR-615-3p CLASH 23622248
MIRT054554 hsa-miR-26b-5p ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot 24565101
MIRT054554 hsa-miR-26b-5p ImmunofluorescenceLuciferase reporter assayqRT-PCRWestern blot 24565101
MIRT437449 hsa-miR-143-3p Luciferase reporter assayqRT-PCRWestern blot 24105952
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
DR1 Unknown 21126370
ELK4 Unknown 21126370
STAT3 Unknown 15764709
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IPI 17974920
GO:0000785 Component Chromatin ISA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 9556573
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 10644740
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601426 7972 ENSG00000177463
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P49116
Protein name Nuclear receptor subfamily 2 group C member 2 (Orphan nuclear receptor TAK1) (Orphan nuclear receptor TR4) (Testicular receptor 4)
Protein function Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrog
PDB 3P0U , 7XV6 , 7XV8 , 7XV9 , 7XVA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00105 zf-C4 115 184 Zinc finger, C4 type (two domains) Domain
PF00104 Hormone_recep 371 567 Ligand-binding domain of nuclear hormone receptor Domain
Sequence
MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAG
TGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVC
GDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEM
GMKM
ESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLL
DPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQ
PEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGP
LLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVR
ACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCN
SMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRL
ARILVRLPALRLMSSNITEELFFTGLI
GNVSIDSIIPYILKMETAEYNGQITGASL
Sequence length 596
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Nuclear Receptor transcription pathway